Skip to main content
Top
Published in: BMC Urology 1/2022

Open Access 01-12-2022 | Overactive Bladder | Research

A new nomogram of urinary flow rate and volume based on multiple measurements per healthy adult Japanese men using a portable uroflowmeter (P-Flowdiary®)

Authors: Masatake Shinohara, Kazumasa Torimoto, Chie Matsushita, Daisuke Gotoh, Hisashi Yoshida, Toshihisa Saka, Yoshihiko Hirao, Akihide Hirayama, Kiyohide Fujimoto

Published in: BMC Urology | Issue 1/2022

Login to get access

Abstract

Background

To develop a nomogram of urinary volume and flow based on the data of Japanese men without lower urinary tract symptoms and multiple flows per participant whose characteristics were clear.

Methods

Overall, 101 Japanese male volunteers without lower urinary tract symptoms aged between 20 and 59 years were enrolled. A portable uroflowmeter (P-Flowdiary®) was used to record urinary information (flow rate and volume) for 2 successive days. The model (quadratic, linear, or logarithmic regression) most fit for the relationship between maximum flow rate and voided volume was determined. The maximum flow rate at > 150 mL was compared among the 20–29-, 30–39-, 40–49-, and 50–59-year age groups. Nomograms appropriate for the age groups were created.

Results

The mean age, International Prostate Symptom Score, and Overactive Bladder Symptom Score were 38.5 years, 0.42, and 0.24, respectively. The quadratic regression model was the most fit because its mean coefficient determination was 0.93 ± 0.06. The mean maximum flow rate was significantly lower in the 50–59-year age group (21.8 ± 5.05 mL/s, P < 0.01) than in the younger groups (24.14 ± 4.94, 24.05 ± 6.99, and 24.64 ± 5.72 mL/s). The 2 nomograms are Y = 28.99 {1 − exp(− 0.01 × X)} and Y = 25.67 {1 − exp(− 0.01 × X)} for the 20–49- and 50–59-year age groups, respectively.

Conclusions

The nomogram can predict maximum flow rate based on voided volume in Japanese men aged 20–59 years without lower urinary tract symptoms.
Literature
1.
go back to reference Fujimura T, Kume H, Nishimatsu H, Sugihara T, Nomiya A, Tsurumaki Y, et al. Assessment of lower urinary tract symptoms in men by international prostate symptom score and core lower urinary tract symptom score. BJU Int. 2012;109:1512–6.CrossRef Fujimura T, Kume H, Nishimatsu H, Sugihara T, Nomiya A, Tsurumaki Y, et al. Assessment of lower urinary tract symptoms in men by international prostate symptom score and core lower urinary tract symptom score. BJU Int. 2012;109:1512–6.CrossRef
2.
go back to reference Homma Y, Yoshida M, Seki N, Yokoyama O, Kakizaki H, Gotoh M, et al. Symptom assessment tool for overactive bladder syndrome – overactive bladder symptom score. Urology. 2006;68:318–23.CrossRef Homma Y, Yoshida M, Seki N, Yokoyama O, Kakizaki H, Gotoh M, et al. Symptom assessment tool for overactive bladder syndrome – overactive bladder symptom score. Urology. 2006;68:318–23.CrossRef
3.
go back to reference Homma Y, Yoshida M, Yamanishi T, Gotoh M. Core lower urinary tract symptom score (CLSS) questionnaire: a reliable tool in the overall assessment of lower urinary tract symptoms. Int J Urol. 2008;15:816–20.CrossRef Homma Y, Yoshida M, Yamanishi T, Gotoh M. Core lower urinary tract symptom score (CLSS) questionnaire: a reliable tool in the overall assessment of lower urinary tract symptoms. Int J Urol. 2008;15:816–20.CrossRef
4.
go back to reference Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, et al. The standardisation of terminology of lower urinary tract function: report from the standardisation sub-committee of the international continence society. Neurourol Urodyn. 2002;21:167–78.CrossRef Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, et al. The standardisation of terminology of lower urinary tract function: report from the standardisation sub-committee of the international continence society. Neurourol Urodyn. 2002;21:167–78.CrossRef
5.
go back to reference Rosier PFWM, Schaefer W, Lose G, Goldman HB, Guralnick M, Eustice S, et al. International continence society good urodynamic practices and terms 2016: urodynamics, uroflowmetry, cystometry, and pressure-flow study. Neurourol Urodyn. 2017;36:1243–60.CrossRef Rosier PFWM, Schaefer W, Lose G, Goldman HB, Guralnick M, Eustice S, et al. International continence society good urodynamic practices and terms 2016: urodynamics, uroflowmetry, cystometry, and pressure-flow study. Neurourol Urodyn. 2017;36:1243–60.CrossRef
6.
go back to reference De La Rosette JJ, Witjes WP, Debruyne FM, Kersten PL, Wijkstra H. Improved reliability of uroflowmetry investigations: results of a portable home-based uroflowmetry study. Br J Urol. 1996;78:385–90.CrossRef De La Rosette JJ, Witjes WP, Debruyne FM, Kersten PL, Wijkstra H. Improved reliability of uroflowmetry investigations: results of a portable home-based uroflowmetry study. Br J Urol. 1996;78:385–90.CrossRef
7.
go back to reference Jørgensen JB, Jacobsen HL, Bagi P, Hvarnes H, Colstrup H. Home uroflowmetry by means of the Da Capo home uroflowmeter. Eur Urol. 1998;33:64–8.CrossRef Jørgensen JB, Jacobsen HL, Bagi P, Hvarnes H, Colstrup H. Home uroflowmetry by means of the Da Capo home uroflowmeter. Eur Urol. 1998;33:64–8.CrossRef
8.
go back to reference Boci R, Fall M, Waldén M, Knutson T, Dahlstrand C. Home uroflowmetry: improved accuracy in outflow assessment. Neurourol Urodyn. 1999;18:25–32.CrossRef Boci R, Fall M, Waldén M, Knutson T, Dahlstrand C. Home uroflowmetry: improved accuracy in outflow assessment. Neurourol Urodyn. 1999;18:25–32.CrossRef
9.
go back to reference Golomb J, Lindner A, Siegel Y, Korczak D. Variability and circadian changes in home uroflowmetry in patients with benign prostatic hyperplasia compared to normal controls. J Urol. 1992;147:1044–7.CrossRef Golomb J, Lindner A, Siegel Y, Korczak D. Variability and circadian changes in home uroflowmetry in patients with benign prostatic hyperplasia compared to normal controls. J Urol. 1992;147:1044–7.CrossRef
10.
go back to reference Siroky MB, Olsson CA, Krane RJ. The flow rate nomogram: I. Development J Urol. 1979;122:665–8.CrossRef Siroky MB, Olsson CA, Krane RJ. The flow rate nomogram: I. Development J Urol. 1979;122:665–8.CrossRef
11.
go back to reference Yachiku S. Clinical evaluation of the uroflowmetry. Hinyokika Kiyo. 1981;27:1019–24. Yachiku S. Clinical evaluation of the uroflowmetry. Hinyokika Kiyo. 1981;27:1019–24.
12.
go back to reference Haylen BT, Ashby D, Sutherst JR, Frazer MI, West CR. Maximum and average urine flow rates in normal male and female populations – the Liverpool nomograms. Br J Urol. 1989;64:30–8.CrossRef Haylen BT, Ashby D, Sutherst JR, Frazer MI, West CR. Maximum and average urine flow rates in normal male and female populations – the Liverpool nomograms. Br J Urol. 1989;64:30–8.CrossRef
13.
go back to reference Susset JG, Picker P, Kretz M, Jorest R. Critical evaluation of uroflowmeters and analysis of normal curves. J Urol. 1973;109:874–8.CrossRef Susset JG, Picker P, Kretz M, Jorest R. Critical evaluation of uroflowmeters and analysis of normal curves. J Urol. 1973;109:874–8.CrossRef
14.
go back to reference Jørgensen JB, Jensen KM, Mogensen P. Age-related variation in urinary flow variables and flow curve patterns in elderly males. Br J Urol. 1992;69:265–71.CrossRef Jørgensen JB, Jensen KM, Mogensen P. Age-related variation in urinary flow variables and flow curve patterns in elderly males. Br J Urol. 1992;69:265–71.CrossRef
15.
go back to reference Kranse R, van Mastrigt R. Causes for variability in repeated pressure-flow measurements. Urology. 2003;61:930–4.CrossRef Kranse R, van Mastrigt R. Causes for variability in repeated pressure-flow measurements. Urology. 2003;61:930–4.CrossRef
16.
go back to reference Hozawa A, Okamura T, Oki I, Murakami Y, Kadowaki T, Nakamura K, et al. Relationship between BMI and all-cause mortality in Japan: NIPPON DATA80. Obesity. 2008;16:1714–7.CrossRef Hozawa A, Okamura T, Oki I, Murakami Y, Kadowaki T, Nakamura K, et al. Relationship between BMI and all-cause mortality in Japan: NIPPON DATA80. Obesity. 2008;16:1714–7.CrossRef
17.
go back to reference Cantiello F, Cicione A, Salonia A, Autorino R, Ucciero G, Tucci L, et al. Metabolic syndrome correlates with peri-urethral fibrosis secondary to chronic prostate inflammation: evidence of a link in a cohort of patients undergoing radical prostatectomy. Int J Urol. 2014;21:264–9.CrossRef Cantiello F, Cicione A, Salonia A, Autorino R, Ucciero G, Tucci L, et al. Metabolic syndrome correlates with peri-urethral fibrosis secondary to chronic prostate inflammation: evidence of a link in a cohort of patients undergoing radical prostatectomy. Int J Urol. 2014;21:264–9.CrossRef
18.
go back to reference Fusco F, Creta M, De Nunzio C, Iacovelli V, Mangiapia F, Marzi VL, et al. Progressive bladder remodeling due to bladder outlet obstruction: a systematic review of morphological and molecular evidences in humans. BMC Urol. 2018;18:15.CrossRef Fusco F, Creta M, De Nunzio C, Iacovelli V, Mangiapia F, Marzi VL, et al. Progressive bladder remodeling due to bladder outlet obstruction: a systematic review of morphological and molecular evidences in humans. BMC Urol. 2018;18:15.CrossRef
19.
go back to reference Suebnukanwattana T, Lohsiriwat S, Chaikomin R, Tantiwongse A, Soontrapa S. Uroflowmetry in normal Thai participants. J Med Assoc Thai. 2003;86:353–60.PubMed Suebnukanwattana T, Lohsiriwat S, Chaikomin R, Tantiwongse A, Soontrapa S. Uroflowmetry in normal Thai participants. J Med Assoc Thai. 2003;86:353–60.PubMed
20.
go back to reference Pernkopf D, Plas E, Lang T, Daha K, Kubin K, Treu T, et al. Uroflow nomogram for male adolescents. J Urol. 2005;174:1436–9.CrossRef Pernkopf D, Plas E, Lang T, Daha K, Kubin K, Treu T, et al. Uroflow nomogram for male adolescents. J Urol. 2005;174:1436–9.CrossRef
21.
go back to reference Thakur ND, Mulay AR, Satav VP, Mane DA, Sabale VP, Kankalia SK. Uroflow nomogram for healthy, 15–40 year old Indian men. Indian J Urol. 2016;32:293–5.CrossRef Thakur ND, Mulay AR, Satav VP, Mane DA, Sabale VP, Kankalia SK. Uroflow nomogram for healthy, 15–40 year old Indian men. Indian J Urol. 2016;32:293–5.CrossRef
22.
go back to reference Kumar V, Dhabalia JV, Nelivigi GG, Punia MS, Suryavanshi M. Age, gender, and voided volume dependency of peak urinary flow rate and uroflowmetry nomogram in the Indian population. Indian J Urol. 2009;25:461–6.CrossRef Kumar V, Dhabalia JV, Nelivigi GG, Punia MS, Suryavanshi M. Age, gender, and voided volume dependency of peak urinary flow rate and uroflowmetry nomogram in the Indian population. Indian J Urol. 2009;25:461–6.CrossRef
23.
go back to reference Masumori N, Tsukamoto T, Kumamoto Y, Miyake H, Rhodes T, Girman CJ, et al. Japanese men have smaller prostate volumes but comparable urinary flow rates relative to American men: results of community based studies in 2 countries. J Urol. 1996;155:1324–7.CrossRef Masumori N, Tsukamoto T, Kumamoto Y, Miyake H, Rhodes T, Girman CJ, et al. Japanese men have smaller prostate volumes but comparable urinary flow rates relative to American men: results of community based studies in 2 countries. J Urol. 1996;155:1324–7.CrossRef
24.
go back to reference Bross S, Schumacher S, Scheepe JR, Zendler S, Braun PM, Alken P, et al. Effects of acute urinary bladder overdistension on bladder response during sacral neurostimulation. Eur Urol. 1999;36:354–9.CrossRef Bross S, Schumacher S, Scheepe JR, Zendler S, Braun PM, Alken P, et al. Effects of acute urinary bladder overdistension on bladder response during sacral neurostimulation. Eur Urol. 1999;36:354–9.CrossRef
Metadata
Title
A new nomogram of urinary flow rate and volume based on multiple measurements per healthy adult Japanese men using a portable uroflowmeter (P-Flowdiary®)
Authors
Masatake Shinohara
Kazumasa Torimoto
Chie Matsushita
Daisuke Gotoh
Hisashi Yoshida
Toshihisa Saka
Yoshihiko Hirao
Akihide Hirayama
Kiyohide Fujimoto
Publication date
01-12-2022
Publisher
BioMed Central
Published in
BMC Urology / Issue 1/2022
Electronic ISSN: 1471-2490
DOI
https://doi.org/10.1186/s12894-022-01086-5

Other articles of this Issue 1/2022

BMC Urology 1/2022 Go to the issue