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01-12-2020 | Ovarian Cancer | Research article

Indocyanine green fluorescence-guided intraoperative detection of peritoneal carcinomatosis: systematic review

Authors: Gian Luca Baiocchi, Federico Gheza, Sarah Molfino, Luca Arru, Marco Vaira, Simone Giacopuzzi

Published in: BMC Surgery | Issue 1/2020

Abstract

Background

To review the available clinical data about the value of Indocyanine Green (ICG) fluorescence imaging for intraoperative detection of peritoneal carcinomatosis.

Methods

We conducted a systematic review, according to the PRISMA guidelines, for clinical series investigating the possible role of ICG fluorescence imaging in detecting peritoneal carcinomatosis during surgical treatment of abdominal malignancies. With the aim to analyze actual application in the daily clinical practice, papers including trials with fluorophores other than ICG, in vitro and animals series were excluded. Data on patients and cancer features, timing, dose and modality of ICG administration, sensitivity, specificity and accuracy of fluorescence diagnosis of peritoneal nodules were extracted and analyzed.

Results

Out of 192 screened papers, we finally retrieved 7 series reporting ICG-guided detection of peritoneal carcinomatosis. Two papers reported the same cases, thus only 6 series were analyzed, for a total of 71 patients and 353 peritoneal nodules. The investigated tumors were colorectal carcinomas in 28 cases, hepatocellular carcinoma in 16 cases, ovarian cancer in 26 cases and endometrial cancer in 1 case. In all but 4 cases, the clinical setting was an elective intervention in patients known as having peritoneal carcinomatosis. No series reported a laparoscopic procedure. Technical data of ICG management were consistent across the studies. Overall, 353 lesions were harvested and singularly evaluated. Sensitivity varied from 72.4 to 100%, specificity from 54.2 to 100%. Two series reported that planned intervention changed in 25 and 29% of patients, respectively.

Conclusion

Indocyanine Green based fluorescence of peritoneal carcinomatosis is a promising intraoperative tool for detection and characterization of peritoneal nodules in patients with colorectal, hepatocellular, ovarian carcinomas. Further prospective studies are needed to fix its actual diagnostic value on these and other abdominal malignancies with frequent spread to peritoneum.

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Title: Indocyanine green fluorescence-guided intraoperative detection of peritoneal carcinomatosis: systematic review
Authors: Gian Luca Baiocchi
Federico Gheza
Sarah Molfino
Luca Arru
Marco Vaira
Simone Giacopuzzi
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Ovarian Cancer
Ovarian Cancer
Gastric Cancer
Gastric Cancer
Peritoneal Cancer
Peritoneal Carcinomatosis
Colorectal Cancer
Colorectal Cancer
Published in: BMC Surgery / Issue 1/2020
Electronic ISSN: 1471-2482
DOI: https://doi.org/10.1186/s12893-020-00821-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Indocyanine green fluorescence-guided intraoperative detection of peritoneal carcinomatosis: systematic review

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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