Skip to main content
Top
Published in: BMC Musculoskeletal Disorders 1/2024

Open Access 01-12-2024 | Cefazolin | Research

Prolonged efficacy of cefazolin in intraosseous regional prophylaxis for total knee arthroplasty: a rabbit model study

Authors: Jing-Yu Zhang, Ling-Chen Ye, Yu-bo Liu, Xiao Yu, Xiang-Xin Zhang, Guang-Xiang Chen, Ren-Jie Xu

Published in: BMC Musculoskeletal Disorders | Issue 1/2024

Login to get access

Abstract

Background

A novel approach known as intraosseous regional administration (IORA) has emerged as a technique for delivering prophylactic antibiotics, and it results in higher tissue concentrations around the knee. It is hypothesized that IORA of cefazolin for antibiotic prophylaxis during total knee arthroplasty will result in sustained effective levels for a longer duration. The aim of the current study was to investigate temporal changes in peri-knee cefazolin blood concentrations after IORA of cefazolin.

Methods

Twelve rabbits were randomly divided into two groups, with six rabbits in each group. In control group a single intravenous bolus injection of cefazolin (10 mL, 100 mg) was administered into the marginal ear vein. In experimental groupexperimental group the same dose of cefazolin was injected into the left tibial marrow cavity after tourniquet inflation at the base of the left thigh. Blood samples were collected periodically at different timepoints, and cefazolin concentrations were determined.

Results

The intraosseous treatment resulted in significant differences in plasma cefazolin concentrations at all timepoints. Experimental group exhibited higher plasma cefazolin concentrations than control group.

Conclusions

Cefazolin in intraosseous regional prophylaxis exhibits effectiveness in intraoperative antibiotic prophylaxis by maintaining concentrations above the minimum inhibitory concentration for extended durations, rather than relying solely on high concentrations.
Literature
Metadata
Title
Prolonged efficacy of cefazolin in intraosseous regional prophylaxis for total knee arthroplasty: a rabbit model study
Authors
Jing-Yu Zhang
Ling-Chen Ye
Yu-bo Liu
Xiao Yu
Xiang-Xin Zhang
Guang-Xiang Chen
Ren-Jie Xu
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2024
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-024-07238-y

Other articles of this Issue 1/2024

BMC Musculoskeletal Disorders 1/2024 Go to the issue