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BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2015

Open Access 01-12-2015 | Research article

Effects of resting modes on human lumbar spines with different levels of degenerated intervertebral discs: a finite element investigation

Authors: Ruoxun Fan, He Gong, Sen Qiu, Xianbin Zhang, Juan Fang, Dong Zhu

Published in: BMC Musculoskeletal Disorders | Issue 1/2015

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Abstract

Background

The negative effect of long-term working load on lumbar is widely known. However, insertion of different resting modes on long-term working load, and its effects on the lumbar spine is rarely studied. The purpose of this study was to investigate the biomechanical responses of lumbar spine with different levels of degenerated intervertebral discs under different working-resting modes.

Methods

Four poroelastic finite element models of lumbar spinal segments L2-L3 with different grades of disc degeneration were developed. Four different loading conditions represented four different resting frequencies, namely, no rest, one-time long rest, three-time moderate rests, and five-time short rests, on the condition that the total resting time was the same except in the no rest mode. Loading amplitudes of diurnal activities included 100 N, 300 N, and 500 N.

Results

With increasing resting frequency, the axial effective stress and fluid loss decreased, whereas the pore pressure and radial displacement increased. Under different resting frequencies, the changing rate of each biomechanical parameter was different.

Conclusions

Under a situation of fixed total resting time, high resting frequency was advisable. If sufficient resting frequency was unavailable for healthy people as well as patients with mildly and moderately degenerated intervertebral discs, they could similarly benefit from relatively less resting frequencies. However, one-time rest will not be useful in cases where intervertebral discs were seriously degenerated. Reasonable working-resting modes for different degrees of disc degeneration, which could assist patients achieve a better restoration, were provided in this study.
Literature
1.
Adams MA, Roughley PJ. What is intervertebral disc degeneration, and what causes it? Spine. 2006;31(18):2151–61.
2.
Jackson AR, Yuan TY, Huang CY, Brown MD, Gu WY. Nutrient transport in human annulus fibrosus is affected by compressive strain and anisotropy. Ann Biomed Eng. 2012;40(12):2551–8.
3.
Urban JPG, Maroudas A. Swelling of the intervertebral disc in vitro. Connective Tissue Res. 1981;9(1):1–10.
4.
Adams MA, Dolan P. Intervertebral disc degeneration: evidence for two distinct phenotypes. J Anat. 2012;221(6)Suppl 1 :497–506.
5.
Galbusera F, Schmidt H, Wilke CN, Gottschalk A, Wilke HJ. The mechanical response of the lumbar spine to different combinations of disc degenerative changes investigated using randomized poroelastic finite element models. Eur Spine J. 2011;20(4):563–71.
6.
Johannessen W, Elliott DM. Effects of degeneration on the biphasic material properties of human nucleus pulposus in confined compression. Spine. 2005;30(24):724–9.
7.
Pfirrmann CWA, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine. 2001;26(17):1873–8.
8.
Thompson JP, Pearce RH, Schechter MT, Adams ME, Tsang IKY, Bishop PB. Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc. Spine. 1990;15(5):411–5.
9.
Wilke HJ, Rohlmann F, Wilke CN, Werner K, Claes L, Kettler A. Validity and interobserver agreement of a new radiographic grading system for intervertebral disc degeneration: part I. lumbar spine. Eur Spine J. 2006;15(6):720–30.
10.
Xu H, Tang H, Guan XM, Jiang FG, Xu N, Ju W, et al. Biomechanical comparison of posterior lumbar interbody fusion and transforaminal lumbar interbody fusion by finite element analysis. Neurosurgery. 2013;72 Suppl 1:21–6.
11.
Massey CJ, Donkelaar CCV, Vresilovic E, Zavaliangos A, Marcolongo M. Effects of aging and degeneration on the human intervertebral disc during the diurnal cycle: a finite element study. J Orthop Res. 2012;30(1):122–8.
12.
Natarajan RN, Williams JR, Andersson GBJ. Modeling changes in intervertebral disc mechanics with degeneration. J Bone Joint Surg Am. 2006;88A Suppl 2:36–40.
13.
Schmidt H, Kettler A, Rohlmann A, Claes L, Wilke HJ. The risk of disc prolapses with complex loading in different degrees of disc degeneration-a finite element analysis. Clin Biomech. 2007;22(9):988–98.
14.
Keller TS, Spengler DM, Hansson TH. Mechanical behavior of the human lumbar spine. I. Creep analysis during static compressive loading. J Orthop Res. 1987;5(4):467–78.
15.
Fujiwara A, Lim TH, An HS, Tanaka N, Jeon CH, Andersson GBJ, et al. The effect of disc degeneration and facet joint osteoarthritis on the segmental flexibility of the lumbar spine. Spine. 2000;25(23):3036–44.
16.
Tanaka N, An HS, Lim TH, Fujiwara A, Jeon CH, Haughton VM. The relationship between disc degeneration and flexibility of the lumbar spine. Spine J. 2001;1(1):47–56.
17.
Sato K, Kikuchi S, Yonezawa T. In vivo intradiscal pressure measurement in healthy individuals and in patients with ongoing back problems. Spine. 1999;24(23):2468–74.
18.
Nikkhoo M, Haghpanahi M, Wang JL, Parnianpour M. A poroelastic finite element model to describe the time-dependent response of lumbar intervertebral disc. J Med Imaging Health Inf. 2011;1(3)Suppl 1 :246–51.
19.
Schmidt H, Adl AS, Galbusera F, Wilke HJ. Response analysis of the lumbar spine during regular daily activities-a finite element analysis. J Biomech. 2010;43(10):1849–56.
20.
Schmidt H, Bashkuev M, Galbusera F, Wilke HJ, Adl AS. Finite element study of human lumbar disc nucleus replacements. Comp Methods Biomech Biomed Eng. 2014;17(16):1762–76.
21.
Schmidt H, Bashkuev M, Dreischarf M, Rohlmann A, Duda G, Wilke HJ, et al. Computational biomechanics of a lumbar motion segment in pure and combined shear loads. J Biomech. 2013;46(14):2513–21.
22.
Galbusera F, Schmidt H, Wilke CN, Wilke HJ. The effect of degenerative morphological changes of the intervertebral disc on the lumbar spine biomechanics: a poroelastic finite element investigation. Comp Methods Biomech Biomed Eng. 2011;14(8):729–39.
23.
Qasim M, Natarajan RN, An HS, Andersson GBJ. Damage accumulation location under cyclic loading in the lumbar disc shifts from inner annulus lamellae to peripheral annulus with increasing disc degeneration. J Biomech. 2013;47(1):24–31.
24.
Qasim M, Natarajan RN, An HS, Andersson GBJ. Initiation and progression of mechanical damage in the intervertebral disc under cyclic loading using continuum damage mechanics methodology: a finite element study. J Biomech. 2012;45(11):1934–40.
25.
Schmidt AL, Paskoff G, Shender BS, Bass CR. Risk of lumbar spine injury from cyclic compressive loading. Spine. 2012;37(26):1614–21.
26.
Yoganandan N, Cusick JF, Pintar FA, Droese K, Reinartz J. Cyclic compression-flexion loading of the human lumbar spine. Spine. 1994;19(7):784–91.
27.
Natarajan RN, Lavender SA, An HA, Andersson GBJ. Biomechanical response of a lumbar intervertebral disc to manual lifting activities. Spine. 2008;33(18):1958–65.
28.
Schmidt H, Kettler A, Heuer F, Simon U, Claes L, Wilke HJ. Intradiscal pressure, shear strain, and fiber strain in the intervertebral disc under combined loading. Spine. 2007;32(7):748–55.
29.
Cassidy JJ, Hiltner A, Baer E. Hierarchical structure of the intervertebral disc. Connect Tissue Res. 1989;23(1):75–88.
30.
Iatridis JC, Setton LA, Foster RJ, Rawlins BA, Weidenbaum M, Mow VC. Degeneration affects the anisotropic and nonlinear behaviors of human anulus fibrosus in compression. J Biomech. 1998;31(6):535–44.
31.
Rohlmann A, Zander T, Schmidt H, Wilke HJ, Bergmann G. Analysis of the influence of disc degeneration on the mechanical behaviour of a lumbar motion segment using the finite element method. J Biomech. 2006;39(13):2484–90.
32.
Galbusera F, Schmidt H, Noailly J, Malandrino A, Lacroix D, Wilke HJ, et al. Comparison of four methods to simulate swelling in poroelastic finite element models of intervertebral discs. J Mech Behav Biomed. 2011;4(7):1234–41.
33.
Sharma M, Langrana NA, Rodriguez J. Role of ligaments and facets in lumbar spinal stability. Spine. 1995;20(8):887–900.
34.
Argoubi M, Adl AS. Poroelastic creep response analysis of a lumbar motion segment in compression. J Biomech. 1996;29(10):1331–9.
35.
Xiao ZT, Wang LY, Gong H, Zhu D. Biomechanical evaluation of three surgical scenarios of posterior lumbar interbody fusion by finite element analysis. Biomed Eng Online. 2012;11:31.
36.
Rohlmann A, Zander T, Graichen F, Dreischarf M, Bergmann G. Measured loads on a vertebral body replacement during sitting. Spine J. 2011;11(9):870–5.
37.
Schmidt H, Galbusera F, Wilke HJ, Adl AS. Remedy for fictive negative pressures in biphasic finite element models of the intervertebral disc during unloading. Comp Methods Biomech Biomed Eng. 2011;14(3):293–303.
38.
Dhillon N, Bass EC, Lotz JC. Effect of frozen storage on the creep behavior of human intervertebral discs. Spine. 2001;26(8):883–8.
39.
Pollintine P, Luo J, Jones BO, Dolan P, Adams MA. Bone creep can cause progressive vertebral deformity. Bone. 2009;45(3):466–72.
40.
Heuer F, Schmidt H, Schmidt H, Claes L, Wilke HJ. Creep associated changes in intervertebral disc bulging obtained with a laser scanning device. Clin Biomech. 2007;22(7):737–44.
41.
Heuer F, Schmidt H, Claes L, Wilke HJ. Stepwise reduction of functional spinal structures increase vertebral translation and intradiscal pressure. J Biomech. 2007;40(2):795–803.
42.
Roberts BV, Moore RJ, Fraser RD. The natural history of age-related disc degeneration: the influence of age and pathology on cell populations in the L4-L5 disc. Spine. 2008;33(25):2767–73.
43.
Seidler A, Bergmann A, Jager M, Ellegast R, Ditchen D, Elsner G, et al. Cumulative occupational lumbar load and lumbar disc disease-results of a German multi-center case–control study (EPILIFT). BMC Musculoskelet Disord. 2009;10:48.
44.
Henriksson HB, Thornemo M, Karlsson C, Hägg O, Junevik K, Lindahl A, et al. Identification of cell proliferation zones, progenitor cells and a potential stem cell niche in the intervertebral disc region: a study in four species. Spine. 2009;34(21):2278–87.
45.
Mizrahi O, Sheyn D, Tawackoli W, Ben-David S, Su S, Li N, et al. Nucleus pulposus degeneration alters properties of resident progenitor cells. Spine J. 2013;13(7):803–14.
46.
Cabraja M, Endres M, Hegewald AA, Vetterlein S, Thomé C, Woiciechowsky C, et al. A 3D environment for anulus fibrosus regeneration Laboratory investigation. J Neurosurg Spine. 2012;17(2):177–83.
47.
Sasaki N, Henriksson HB, Runesson E, Larsson K, Sekiguchi M, Kikuchi SI, et al. Physical exercise affects cell proliferation in lumbar intervertebral disc regions in rats. Spine. 2012;37(17):1440–7.
48.
Brisby H, Wei AQ, Molloy T, Chung SA, Murrell GA, Diwan AD. The effect of running exercise on intervertebral disc extracellular matrix production in a Rat model. Spine. 2010;35(15):1429–36.
49.
Naylor AS, Persson AI, Eriksson PS, Jonsdottir IH, Thorlin T. Extended voluntary running inhibits exercise-induced adult hippocampal progenitor proliferation in the spontaneously hypertensive rat. J Neurophysiol. 2005;93(5):2406–14.
50.
Brisby H, Papadimitriou N, Runesson E, Sasaki N, Lindahl A, Henriksson HB. Moderate physical exercise results in increased cell activity in articular cartilage of the knee joint in rats. Cells Tissues Organs. 2013;198(3):237–48.
Metadata
Title
Effects of resting modes on human lumbar spines with different levels of degenerated intervertebral discs: a finite element investigation
Authors
Ruoxun Fan
He Gong
Sen Qiu
Xianbin Zhang
Juan Fang
Dong Zhu
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2015
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-015-0686-z

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