Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2015

Open Access 01-12-2015 | Research article

Consecutive assessment of FA and ADC values of normal lumbar nerve roots from the junction of the dura mater

Authors: Ryo Miyagi, Toshinori Sakai, Eiko Yamabe, Hiroshi Yoshioka

Published in: BMC Musculoskeletal Disorders | Issue 1/2015

Login to get access

Abstract

Background

Diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) are widely used in the evaluation of the central nervous system and recently have been reported as a potential tool for diagnosis of the peripheral nerve or the lumbar nerve entrapment. The purpose of this study was to evaluate consecutive changes in apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values of normal lumbar nerve roots from the junction of the dura mater.

Methods

The lumbar spinal nerves were examined in 6 male healthy volunteers (mean age, 35 years) with no experiences of sciatica, with a 3.0-T MR unit using a five-element phased-array surface coil. DTI was performed with the following imaging parameters: 11084.6/73.7 ms for TR/TE; b-value, 800 s/mm2; MPG, 33 directions; slice thickness, 1.5 mm; and total scan time, 7 min 35 s. ADC and FA values at all consecutive points along the L4, L5 and S1 nerves were quantified on every 1.5 mm slice from the junction of the dura mater using short fiber tracking.

Results

ADC values of all L4, 5, and S1 nerve roots decreased linearly up to 15 mm from the dura junction and was constant distally afterward. ADC values in the proximal portion demonstrated S1 > L5 > L4 (p < 0.05). On the other hand, FA values increased linearly up to 15 mm from the dura junction, and was constant distally afterward. FA values in the proximal portion showed L4 > L5 > S1 (p < 0.05).

Conclusion

Our study demonstrated that ADC and FA values of each L4, 5, and S1 at the proximal portion from the junction of the dura matter changed linearly. It would be useful to know the normal profile of DTI values by location of each nerve root so that we can detect subtle abnormalities in each nerve root.
Literature
1.
Eguchi Y, Ohtori S, Orita S, Kamoda H, Arai G, Ishikawa T, et al. Quantitative Evaluation and Visualization of Lumbar Foraminal Nerve Root Entrapment by Using Diffusion Tensor Imaging:Preliminary Results. AJNR Am J Neuroradiol. 2011;32(10):1824–9.
2.
Eguchi Y, Ohtori S, Yamashita M, Yamauchi K, Suzuki M, Orita S, et al. Diffusion-weighted magnetic resonance imaging of symptomatic nerve root of patients with lumbar disk herniation. Neuroradiology. 2011;53(9):633–41.
3.
Eguchi Y, Ohtori S, Yamashita M, Yamauchi K, Suzuki M, Orita S, et al. Clinical applications of diffusion magnetic resonance imaging of the lumbar foraminal nerve root entrapment. Eur Spine J. 2010;19(11):1874–82.
4.
Balbi V, Budzik JF, Duhamel A, Bera-Louville A, Le Thuc V, Cotten A. Tractography of lumbar nerve roots: initial results. Eur Radiol. 2011;21(6):1153–9.
5.
Kabakci N, Gurses B, Firat Z, Bayram A, Uluğ AM, Kovanlikaya A, et al. Diffusion tensor imaing and tractography of median nerve: normative diffusion values. Am J Roentgenol. 2007;189(4):923–7.
6.
Zhou Y, Kumaravel M, Patel VS, Sheikh KA, Narayana PA, et al. Diffusion tensor imaging of forearm nerves in humans. J Magn Reson Imaging. 2012;36(4):920–7.
7.
Khalil C, Hancart C, Le Thuc V, Chantelot C, Chechin D, Cotten A, et al. Diffusion tensor imaging and tractography of the median nerve in carpal tunnel syndrome: preliminary results. Eur Radiol. 2008;18(10):2283–891.
8.
Hiltunen J, Suortti T, Arvela S, Seppä M, Joensuu R, Hari R. Diffusion tensor imaging and tractography of distal peripheral nerves at 3 T. Clin Neurophysiol. 2005;116(10):2315–23.
9.
Le Bihan D, Breton E, Lallemand D, Grenier P, Cabanis E, Laval-Jeantet M. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology. 1986;161(2):401–7.
10.
Minematsu K, Li L, Fisher M, Sotak CH, Davis MA, Fiandaca MS. Diffusion-weighted magnetic resonance imaging: rapid and quantitative detection of focal brain ischemia. Neurology. 1992;42(1):235–40.
11.
Price SJ, Burnet NG, Donovan T, Green HA, Peña A, Antoun NM, et al. Diffusion tensor imaging of brain tumours at 3 T: a potential tool for assessing white matter tract invasion? Clin Radiol. 2003;58(6):455–62.
12.
Cassol E, Ranjeva JP, Ibarrola D, Mékies C, Manelfe C, Clanet M, et al. Diffusion tensor imaging in multiple sclerosis: a tool for monitoring changes in normal-appearing white matter. Mult Scler. 2004;10(2):188–96.
14.
Agosta F, Absinta M, Sormani MP, Ghezzi A, Bertolotto A, Montanari E, et al. In vivo assessment of cervical cord damage in MS patients: a longitudinal diffusion tensor MRI study. Brain. 2007;130(8):2211–9.
15.
Cohen-Adad J, El Mendili MM, Lehericy S, Pradat PF, Blancho S, Rossignol S, et al. Demyelination and degeneration in the injured human spinal cord detected with diffusion and magnetization transfer MRI. Neuroimage. 2011;55(3):1024–33.
16.
Cohen-Adad J, El Mendili MM, Morizot-Koutlidis R, Lehéricy S, Meininger V, Blancho S, et al. Involvement of spinal sensory pathway in ALS and specificity of cord atrophy to lower motor neuron degeneration. Amyotroph Lateral Scler Frontotemporal Degener. 2013;14(1):30–8.
17.
Tagliafico A1, Calabrese M, Puntoni M, Pace D, Baio G, Neumaier CE, et al. Brachial plexus MR imaging: accuracy and reproducibility of DTI-derived measurements and fibre tractography at 3.0-T. Eur Radiol. 2011;21(8):1764–71.
18.
Hobert MK, Stein VM, Dziallas P, Ludwig DC, Tipold A. Evaluation of normal appearing spinal cord by diffusion tensor imaging, fiber tracking, fractional anisotropy, and apparent diffusion coefficient measurement in 13 dogs. Acta Veterinaria Scandinavica. 2013;55(1):36.
19.
Facon D, Ozanne A, Fillard P, Lepeintre JF, Tournoux-Facon C, Ducreux D. MR diffusion tensor imaging and fiber tracking in spinal cord compression. Am J Neuroradiol. 2005;26(6):1587–94.
Metadata
Title
Consecutive assessment of FA and ADC values of normal lumbar nerve roots from the junction of the dura mater
Authors
Ryo Miyagi
Toshinori Sakai
Eiko Yamabe
Hiroshi Yoshioka
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2015
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-015-0576-4

Other articles of this Issue 1/2015

BMC Musculoskeletal Disorders 1/2015 Go to the issue

Research article

Gender disparities of chronic musculoskeletal disorder burden in the elderly Ghanaian population: study on global ageing and adult health (SAGE WAVE 1)

Research article

Back pain was less explained than leg pain: a cross-sectional study using magnetic resonance imaging in low back pain patients with and without radiculopathy

Research article

Cartilage boundary lubrication synergism is mediated by hyaluronan concentration and PRG4 concentration and structure

Research article

Diffuse idiopathic skeletal hyperostosis (DISH) of the elbow: a controlled radiological study

Research article

Musculoskeletal symptoms in an adolescent athlete population: a comparative study

Research article

Multilevel thoracic ossification of ligamentum flavum coexisted with/without lumbar spinal stenosis: staged surgical strategy and clinical outcomes