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BMC Pulmonary Medicine
Published in: BMC Pulmonary Medicine 1/2015

Open Access 01-12-2015 | Research article

Burkholderia cepacia complex: clinical course in cystic fibrosis patients

Authors: Tania Wrobel Folescu, Claudia Henrique da Costa, Renata Wrobel Folescu Cohen, Orlando Carlos da Conceição Neto, Rodolpho Mattos Albano, Elizabeth Andrade Marques

Published in: BMC Pulmonary Medicine | Issue 1/2015

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Abstract

Background

Pulmonary deterioration after B.cepacia complex (BCC) colonization has a heterogeneous pattern. The aim was to investigate the clinical outcome of BCC colonization in CF patients chronically colonized with P. aeruginosa.

Methods

CF patients chronically colonized with P. aeruginosa were divided into three groups: intermittent (I), chronic (II) and no colonization (III) with BCC. Body mass index (BMI) percentile and spirometric parameters were analyzed at three different times in each group.

Results

Fifty-six patients chronically colonized with P. aeruginosa were included. Of these, 27 also had evidence of BCC colonization (13 intermittent and 14 chronic). BMI percentile was significantly lower among patients chronically colonized by both P. aeruginosa and BCC. Mean values of FEV1 and FVC % were also significantly lower in these patients, both at the time of chronic BCC colonization and 24 months forward.

Conclusions

Chronic BCC colonization is associated with significant loss of lung function. Lower BMI might be a risk factor for chronic BCC colonization, preceding these events.
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Metadata
Title
Burkholderia cepacia complex: clinical course in cystic fibrosis patients
Authors
Tania Wrobel Folescu
Claudia Henrique da Costa
Renata Wrobel Folescu Cohen
Orlando Carlos da Conceição Neto
Rodolpho Mattos Albano
Elizabeth Andrade Marques
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Pulmonary Medicine / Issue 1/2015
Electronic ISSN: 1471-2466
DOI
https://doi.org/10.1186/s12890-015-0148-2

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