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BMC Public Health
Published in: BMC Public Health 1/2016

Open Access 01-12-2016 | Research article

Factors associated with hospitalization for seasonal influenza in a Japanese nonelderly cohort

Authors: Sachiko Ono, Yosuke Ono, Hiroki Matsui, Hideo Yasunaga

Published in: BMC Public Health | Issue 1/2016

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Abstract

Background

Nonelderly patients may require hospitalization if their symptoms of influenza are severe. However, little evidence is available about the risk factors for hospitalization for influenza.

Methods

We used a multicenter outpatient and inpatient database to obtain patients’ characteristics and clinical procedures. We identified patients aged <65 years with a confirmed diagnosis of influenza between October 2013 and December 2014. We used a Cox regression model to identify the risk factors for hospitalization, using a comparison group of individuals with a confirmed diagnosis of influenza but who were not hospitalized.

Results

Of 88,054 patients diagnosed with influenza, 276 (0.3 %) patients were hospitalized. With reference to patients aged 18–64 years, the hazard ratio (95 % confidence interval) for hospitalization in patients aged <2, 2–4, and 5–17 years was 12.25 (8.37–17.93), 4.56 (3.10–6.72) and 1.45 (1.03–2.05), respectively. Anemia, chronic obstructive pulmonary disease, neurologic disease, and regular steroid use were significantly associated with hospitalization. Hazard ratios were adjusted for age, sex, comorbidities, respiratory co-infection, virus type, and influenza season.

Conclusions

Our findings suggest that younger age and several comorbidities are associated with higher probability of hospitalization for influenza.
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Metadata
Title
Factors associated with hospitalization for seasonal influenza in a Japanese nonelderly cohort
Authors
Sachiko Ono
Yosuke Ono
Hiroki Matsui
Hideo Yasunaga
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2016
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-016-3602-z

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