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BMC Psychiatry

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Open Access 01-12-2024 | Antipsychotics | Research

Real-world evidence from a retrospective study on suicide during depression: clinical characteristics, treatment patterns and disease burden

Authors: Han Wang, Nan Lyu, Juan Huang, Bingbing Fu, Lili Shang, Fan Yang, Qian Zhao, Gang Wang

Published in: BMC Psychiatry | Issue 1/2024

Abstract

Background

Suicide stands as both a primary symptom and the direst outcome of major depressive disorder (MDD). The scarcity of effective treatment strategies makes managing MDD patients with suicide especially challenging. Hence, it is crucial to investigate disease characteristics and efficacious therapeutic strategies for these patients, drawing insights from disease databases and real-world data.

Methods

In this retrospective study, MDD patients hospitalized between January 2013 and December 2020 were investigated using Electronic Health Records (EHR) data from Beijing Anding Hospital. The study enrolled 4138 MDD patients with suicidal ideation or behavior (MDS) and 3848 without (MDNS). Demographic data, clinical attributes, treatment approaches, disease burden, and re-hospitalization within one year of discharge were extracted and compared.

Results

Patients in the MDS group were predominantly younger and female, exhibiting a higher prevalence of alcohol consumption, experiencing frequent life stress events, and having an earlier onset age. Re-hospitalizations within six months post-discharge in the MDS group were significantly higher than in the MDNS group (11.36% vs. 8.91%, p < 0.001). Moreover, a more considerable fraction of MDS patients underwent combined electroconvulsive therapy treatment (56.72% vs. 43.71%, p < 0.001). Approximately 38% of patients in both groups were prescribed two or more therapeutic regimes, and over 90% used antidepressants, either alone or combined. Selective serotonin reuptake inhibitors (SSRIs) were the predominant choice in both groups. Furthermore, antidepressants were often prescribed with antipsychotics or mood stabilizers. When medication alterations were necessary, the favoured options involved combination with antipsychotics or transitioning to alternative antidepressants. Yet, in the MDS group, following these initial modifications, the addition of mood stabilizers tended to be the more prioritized alternative.

Conclusions

MDD patients with suicidal ideation or behaviour displayed distinctive demographic and clinical features. They exhibited intricate treatment patterns, a pronounced burden of illness, and an increased likelihood of relapse.

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Title: Real-world evidence from a retrospective study on suicide during depression: clinical characteristics, treatment patterns and disease burden
Authors: Han Wang
Nan Lyu
Juan Huang
Bingbing Fu
Lili Shang
Fan Yang
Qian Zhao
Gang Wang
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Antipsychotics
Antipsychotics
Antidepressant Drugs
Antidepressant Drugs
Suicide
Suicide
Electroconvulsive Therapy
Mood Disorders
Affective Disorder
Published in: BMC Psychiatry / Issue 1/2024
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/s12888-024-05726-y

2024 ASCO Annual Meeting

Springer Medicine

Real-world evidence from a retrospective study on suicide during depression: clinical characteristics, treatment patterns and disease burden

Abstract

Background

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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