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BMC Psychiatry
Published in: BMC Psychiatry 1/2023

Open Access 01-12-2023 | Vitamin D Deficiency | Research

Relationship between serum vitamin D and thyroid hormone profiles in male patients with alcohol dependence

Authors: Yu Liu, Yayun Xu, Yongmei Wang, Liangjun Pang, Xulai Zhang

Published in: BMC Psychiatry | Issue 1/2023

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Abstract

Background

Alcohol dependence (AD) results in several medical problems including vitamin D deficiency and thyroid dysfunction. However, the relationship between these two complications remains unclear. The aim of the present study was to explore the relationship between serum vitamin D and thyroid hormone profiles in male patients with AD.

Methods

A total of 117 male patients with AD were enrolled. Vitamin D deficiency was defined as serum concentrations of the main circulating vitamin D, 25-hydroxy vitamin D [25(OH)D], below 50 nmol/L. The AD patients were divided into two groups accordingly: 46 patients with normal vitamin D levels (normal group) and 71 patients with vitamin D deficiency (deficiency group). The levels of thyroid hormone profiles including total triiodothyronine 3 (TT3), total thyroxine 4 (TT4), thyroid stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) between the two groups were compared. Correlation between the serum levels of 25(OH)D and thyroid hormone profiles was evaluated using simple correlation (Pearson’s correlation) and multivariable analysis using linear regression models.

Results

The prevalence of vitamin D deficiency in male patients with AD is 60.7% (71/117; 95% confidence interval: 51.6–69.1%). Moreover, the serum levels of TT3 (t = -2.682, p = 0.009), TT4 (t = -2.033, p = 0.044), fT3 (t = -2.986, p = 0.003), and fT4 (t = -2.558, p = 0.012) in deficiency group were significantly higher than those in normal group. Post hoc power analyses showed that the power for fT3 was sufficient (power > 0.80). Furthermore, univariate analysis showed that the serum vitamin D levels were negatively correlated with the TT3 (r = -0.189, p = 0.044), fT3 (r = -0.350, p < 0.001), and fT4 (r = -0.198, p = 0.033) levels, while multivariate analysis indicated that only fT3 was independently related to the serum levels of vitamin D in male patients with AD.

Conclusions

These results suggested that the serum vitamin D levels may be associated with fT3 in male patients with AD.
Literature
1.
2.
Banjac Baljak V, Mihajlovic G, Zivlak-Radulovic N, Nezic L, Miskovic M, Banjac V. Association between Vitamin D and Cognitive Deficiency in Alcohol Dependence. Healthc (Basel Switzerland) 2022, 10(9).
3.
Balhara Y, Narang P, Saha S, Kandasamy D, Chattopadhyay N, Goswami R. Bone Mineral density, bone microarchitecture and vertebral fractures in male patients with Alcohol Use Disorders. Alcohol Alcohol (Oxf Oxfs). 2022;57(5):552–8.CrossRef
4.
Stokłosa I, Więckiewicz G, Stokłosa M, Piegza M, Pudlo R, Gorczyca P. Medications for the Treatment of Alcohol Dependence-Current State of Knowledge and Future perspectives from a Public Health Perspective. Int J Environ Res Public Health 2023, 20(3).
5.
Marin M, Pedro M, Perrotte G, Martins-da-Silva A, Lassi D, Blaas I, Castaldelli F, Brisola Dos Santos M, Kortas G, Campos M et al. Pharmacological treatment of Alcohol cravings. Brain Sci 2023, 13(8).
6.
Wallace C, Gordon M, Sinopoulou V, Limketkai B. Vitamin D for the treatment of inflammatory bowel Disease. Cochrane Database Syst Rev. 2023;10(10):CD011806.PubMed
7.
Tardelli VS, Lago M, Silveira DXD, Fidalgo TM. Vitamin D and alcohol: a review of the current literature. Psychiatry Res. 2017;248:83–6.CrossRefPubMed
8.
Banjac Baljak V, Mihajlovic G, Zivlak-Radulovic N, Nezic L, Miskovic M, Banjac V. Association between Vitamin D and Cognitive Deficiency in Alcohol Dependence. Healthcare 2022, 10(9).
9.
Uzdzicki AW, Zych A, Swierad BA, Wawrzynowicz-Syczewska M. The role of vitamin and microelement supplementation in the treatment of ethanol-induced Liver Disease. Przeglad Gastroenterologiczny. 2022;17(4):253–6.PubMedPubMedCentral
10.
Sagaram M, Royer A, Hu H, Rajhans A, Parthasarathy R, Krishnasamy S, Mokshagundam S, Kong M, Schwandt M, Parajuli D et al. Illustration of Gut-Thyroid Axis in Alcohol Use Disorder: Interplay of Gut Dysfunction, Pro-Inflammatory Responses, and Thyroid Function. Cells 2022, 11(19).
11.
Zoeller RT, Fletcher DL, Simonyl A, Rudeen PK. Chronic ethanol treatment reduces the responsiveness of the hypothalamic-pituitary-thyroid axis to central stimulation. Alcohol Clin Exp Res. 1996;20(5):954–60.CrossRefPubMed
12.
Zhao R, Zhang W, Ma C, Zhao Y, Xiong R, Wang H, Chen W, Zheng S. Immunomodulatory Function of Vitamin D and its role in autoimmune thyroid Disease. Front Immunol. 2021;12:574967.CrossRefPubMedPubMedCentral
13.
Li Q, Bi R. Relationship between serum 25-Hydroxyvitamin D Deficiency and thyroid Disease in Postmenopausal Women with type 2 Diabetes Mellitus. Diabetes Metabolic Syndrome and Obesity: Targets and Therapy. 2023;16:1407–14.CrossRefPubMed
14.
Jiang H, Chen X, Qian X, Shao S. Effects of vitamin D treatment on thyroid function and autoimmunity markers in patients with Hashimoto’s thyroiditis-A meta-analysis of randomized controlled trials. J Clin Pharm Ther. 2022;47(6):767–75.CrossRefPubMedPubMedCentral
15.
Guo Y, Wu CY, Deng YH, Wu JL. Associations between serum 25-Hydroxyvitamin D levels and thyroid function parameters in previously healthy children aged 6 to 24 months. Risk Manage Healthc Policy. 2020;13:1647–53.CrossRef
16.
Lee K. Sex-specific relationships between alcohol consumption and vitamin D levels: the Korea National Health and Nutrition Examination Survey 2009. Nutr Res Pract. 2012;6(1):86–90.CrossRefPubMedPubMedCentral
17.
Neupane SP, Lien L, Hilberg T, Bramness JG. Vitamin D deficiency in alcohol-use disorders and its relationship to comorbid major depression: a cross-sectional study of inpatients in Nepal. Drug Alcohol Depend. 2013;133(2):480–5.CrossRefPubMed
18.
Naude CE, Carey PD, Laubscher R, Fein G, Senekal M. Vitamin D and calcium status in South African adolescents with Alcohol Use Disorders. Nutrients. 2012;4(8):1076–94.CrossRefPubMedPubMedCentral
19.
Chen S, Yang W, Guo Z, Lv X, Zou Y. Association between serum vitamin D levels and sensitivity to thyroid hormone indices: a cross-sectional observational study in NHANES 2007–2012. Front Endocrinol. 2023;14:1243999.CrossRef
20.
Zhou L, Wang Y, Su J, An Y, Liu J, Wang G. Vitamin D Deficiency is Associated with impaired sensitivity to thyroid hormones in Euthyroid adults. Nutrients 2023, 15(17).
21.
Misharin A, Hewison M, Chen CR, Lagishetty V, Aliesky HA, Mizutori Y, Rapoport B, McLachlan SM. Vitamin D deficiency modulates Graves’ hyperthyroidism induced in BALB/c mice by thyrotropin receptor immunization. Endocrinology. 2009;150(2):1051–60.CrossRefPubMed
22.
Kano K, Jones G. Direct in vitro effect of thyroid hormones on 25-hydroxyvitamin D3 metabolism in the perfused rat kidney. Endocrinology. 1984;114(2):330–6.CrossRefPubMed
Metadata
Title
Relationship between serum vitamin D and thyroid hormone profiles in male patients with alcohol dependence
Authors
Yu Liu
Yayun Xu
Yongmei Wang
Liangjun Pang
Xulai Zhang
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2023
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-023-05274-x

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