Skip to main content
Top
Published in: BMC Psychiatry 1/2016

Open Access 01-12-2016 | Research article

Prevalence and appropriateness of psychotropic medication prescribing in a nationally representative cross-sectional survey of male and female prisoners in England

Authors: Lamiece Hassan, Jane Senior, Roger T. Webb, Martin Frisher, Mary P. Tully, David While, Jenny J. Shaw

Published in: BMC Psychiatry | Issue 1/2016

Login to get access

Abstract

Background

Mental illness is highly prevalent among prisoners. Although psychotropic medicines can ameliorate symptoms of mental illness, prescribers in prisons must balance clinical needs against risks to safety and security. Concerns have been raised at the large number of prisoners reportedly receiving psychotropic medicines in England. Nonetheless, unlike for the wider community, robust prescribing data are not routinely available for prisons. We investigated gender-specific patterns in the prevalence and appropriateness of psychotropic prescribing in English prisons.

Methods

We studied 6052 men and 785 women in 11 prisons throughout England. This represented 7.9 % of male and 20.5 % of female prisoners nationally. Using a cross-sectional design, demographic and prescription data were collected from clinical records of all prisoners prescribed psychotropic medicines, including hypnotic, anxiolytic, antipsychotic, anti-manic, antidepressant and Central Nervous System stimulant medications. Percentages and 95 % CIs were used to estimate the prevalence of prescribing. The Prescribing Appropriate Indicators tool was used to determine appropriateness. Prevalence Ratios (PR) were generated to make age-adjusted comparisons between prisoners and the general population using a dataset supplied by the Clinical Practice Research Datalink.

Results

Overall, 47.9 % (CI 44.4–51.4) of women and 16.9 % (CI 16.0–17.9) of men in prison were prescribed one or more psychotropic medicines. Compared with the general population, age-adjusted prescribing prevalence was six times higher among women (PR 5.95 CI 5.36–6.61) and four times higher among men (PR 4.02 CI 3.75–4.30). Undocumented or unapproved indications for prescriptions, not listed in the British National Formulary, were recorded in a third (34.7 %, CI 32.5–37.0) of cases, most commonly low mood and personality disorder.

Conclusions

Psychotropic medicines were prescribed frequently in prisons, especially among women, and for a wider range of indications than are currently recommended. These findings raise questions about whether the prescribing of psychotropic medicines in prisons is wholly appropriate and proportionate to the level of clinical need. Prisons need to develop a wider array of treatment responses, other than medicines, to effectively tackle mental illness, challenging behaviours and distress.
Appendix
Available only for authorised users
Literature
2.
go back to reference Fazel S, Seewald K. Severe mental illness in 33,588 prisoners worldwide: systematic review and meta-regression analysis. Br J Psychiatry. 2012;200:364–73.CrossRefPubMed Fazel S, Seewald K. Severe mental illness in 33,588 prisoners worldwide: systematic review and meta-regression analysis. Br J Psychiatry. 2012;200:364–73.CrossRefPubMed
3.
go back to reference Geddes JR, Carney SM, Davies C, et al. Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review. Lancet. 2003;361:653–61.CrossRefPubMed Geddes JR, Carney SM, Davies C, et al. Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review. Lancet. 2003;361:653–61.CrossRefPubMed
4.
go back to reference Gijsman HJ, Geddes JR, Rendell JM, Nolen WA, Goodwin GM. Antidepressants for Bipolar Depression: A Systematic Review of Randomized, Controlled Trials. Am J Psychiatry. 2004;161:1537–47.CrossRefPubMed Gijsman HJ, Geddes JR, Rendell JM, Nolen WA, Goodwin GM. Antidepressants for Bipolar Depression: A Systematic Review of Randomized, Controlled Trials. Am J Psychiatry. 2004;161:1537–47.CrossRefPubMed
5.
go back to reference Smith LA, Cornelius V, Warnock A, Bell A, Young AH. Effectiveness of mood stabilizers and antipsychotics in the maintenance phase of bipolar disorder: a systematic review of randomized controlled trials. Bipolar Disord. 2007;9:394–412.CrossRefPubMed Smith LA, Cornelius V, Warnock A, Bell A, Young AH. Effectiveness of mood stabilizers and antipsychotics in the maintenance phase of bipolar disorder: a systematic review of randomized controlled trials. Bipolar Disord. 2007;9:394–412.CrossRefPubMed
6.
go back to reference Leucht S, Barnes TRE, Kissling W, Engel RR, Correll C, Kane JM. Relapse Prevention in Schizophrenia With New-Generation Antipsychotics: A Systematic Review and Exploratory Meta-Analysis of Randomized, Controlled Trials. Am J Psychiatry. 2003;160:1209–22.CrossRefPubMed Leucht S, Barnes TRE, Kissling W, Engel RR, Correll C, Kane JM. Relapse Prevention in Schizophrenia With New-Generation Antipsychotics: A Systematic Review and Exploratory Meta-Analysis of Randomized, Controlled Trials. Am J Psychiatry. 2003;160:1209–22.CrossRefPubMed
7.
go back to reference Fazel S, Zetterqvist J, Larsson H, Långström N, Lichtenstein P. Antipsychotics, mood stabilisers, and risk of violent crime. Lancet. 2014;384:1206–14.CrossRefPubMedPubMedCentral Fazel S, Zetterqvist J, Larsson H, Långström N, Lichtenstein P. Antipsychotics, mood stabilisers, and risk of violent crime. Lancet. 2014;384:1206–14.CrossRefPubMedPubMedCentral
8.
go back to reference Bartlett A, Dholakia N, England R, et al. Prison prescribing practice: practitioners’ perspectives on why prison is different. Int J Clin Pract. 2014;68:413–7.CrossRefPubMed Bartlett A, Dholakia N, England R, et al. Prison prescribing practice: practitioners’ perspectives on why prison is different. Int J Clin Pract. 2014;68:413–7.CrossRefPubMed
9.
go back to reference RCGP Secure Environments Group. Safer Prescribing in Prisons: Guidance for Clinicians. London: Royal College of General Practitioners; 2011. RCGP Secure Environments Group. Safer Prescribing in Prisons: Guidance for Clinicians. London: Royal College of General Practitioners; 2011.
10.
go back to reference HM Inspectorate of Prisons. The mental health of prisoners: a thematic review of the care and support of prisoners with mental health needs. London: HM Inspectorate of Prisons; 2007. HM Inspectorate of Prisons. The mental health of prisoners: a thematic review of the care and support of prisoners with mental health needs. London: HM Inspectorate of Prisons; 2007.
11.
go back to reference Singleton N, Meltzer H, Gatward R. Psychiatric morbidity among prisoners. London: Office for National Statistics; 1998. Singleton N, Meltzer H, Gatward R. Psychiatric morbidity among prisoners. London: Office for National Statistics; 1998.
12.
go back to reference Elger BS, Goehring C, Revaz SA, Morabia A. Prescription of hypnotics and tranquilisers at the Geneva prison’s outpatient service in comparison to an urban outpatient medical service. Soc Prev Med. 2002;47:39–43.CrossRef Elger BS, Goehring C, Revaz SA, Morabia A. Prescription of hypnotics and tranquilisers at the Geneva prison’s outpatient service in comparison to an urban outpatient medical service. Soc Prev Med. 2002;47:39–43.CrossRef
13.
go back to reference Harcouët L. L’exercice pharmaceutique hospitalier en milieu carcéral [Hospital pharmaceutical practice in prison]. Ann Pharm Françaises. 2010;68:286–90.CrossRef Harcouët L. L’exercice pharmaceutique hospitalier en milieu carcéral [Hospital pharmaceutical practice in prison]. Ann Pharm Françaises. 2010;68:286–90.CrossRef
14.
go back to reference Kjelsberg E, Hartvig P. Too much or too little? Prescription drug use in a nationwide prison population. Int J Prison Health. 2005;1:75–87.CrossRef Kjelsberg E, Hartvig P. Too much or too little? Prescription drug use in a nationwide prison population. Int J Prison Health. 2005;1:75–87.CrossRef
15.
go back to reference Kjelsberg E, Hartvig P. Can morbidity be inferred from prescription drug use? Results from a nation-wide prison population study. Eur J Epidemiol. 2005;20:587–92.CrossRefPubMed Kjelsberg E, Hartvig P. Can morbidity be inferred from prescription drug use? Results from a nation-wide prison population study. Eur J Epidemiol. 2005;20:587–92.CrossRefPubMed
16.
go back to reference Baillargeon J, Contreras SA. Antipsychotic prescribing patterns in the Texas prison system. J Am Acad Psychiatry Law. 2001;29:48–53.PubMed Baillargeon J, Contreras SA. Antipsychotic prescribing patterns in the Texas prison system. J Am Acad Psychiatry Law. 2001;29:48–53.PubMed
17.
go back to reference Baillargeon J, Black SA, Contreras S, Grady J, Pulvino J. Anti-depressant prescribing patterns for prison inmates with depressive disorders. J Affect Disord. 2001;63:225–31.CrossRefPubMed Baillargeon J, Black SA, Contreras S, Grady J, Pulvino J. Anti-depressant prescribing patterns for prison inmates with depressive disorders. J Affect Disord. 2001;63:225–31.CrossRefPubMed
20.
go back to reference Hassan L, Senior J, Frisher M, Edge D, Shaw J. A comparison of psychotropic medication prescribing patterns in East of England prisons and the general population. J Psychopharmacol. 2014;28:357–62.CrossRefPubMed Hassan L, Senior J, Frisher M, Edge D, Shaw J. A comparison of psychotropic medication prescribing patterns in East of England prisons and the general population. J Psychopharmacol. 2014;28:357–62.CrossRefPubMed
21.
go back to reference BMJ Group and the Royal Pharmaceutical Society of Great Britain. BNF (British National Formulary) 64. London: BMJ Group; 2012. BMJ Group and the Royal Pharmaceutical Society of Great Britain. BNF (British National Formulary) 64. London: BMJ Group; 2012.
22.
go back to reference Cantrill JA, Sibbald B, Buetow S. Indicators of the appropriateness of long-term prescribing in general practice in the United Kingdom: consensus development, face and content validity, feasibility, and reliability. Qual Saf Heal Care. 1998;7:130–5.CrossRef Cantrill JA, Sibbald B, Buetow S. Indicators of the appropriateness of long-term prescribing in general practice in the United Kingdom: consensus development, face and content validity, feasibility, and reliability. Qual Saf Heal Care. 1998;7:130–5.CrossRef
23.
go back to reference StataCorp. Stata Statistical Software: Release 12. 2011. StataCorp. Stata Statistical Software: Release 12. 2011.
24.
go back to reference Wilson EB. Probable inference, the law of succession, and statistical inference. J Am Stat Assoc. 1927;22:209–12.CrossRef Wilson EB. Probable inference, the law of succession, and statistical inference. J Am Stat Assoc. 1927;22:209–12.CrossRef
25.
go back to reference Joukamaa M, Heliövaara M, Knekt P, Aromaa A, Raitasalo R, Lehtinen V. Schizophrenia, neuroleptic medication and mortality. Br J Psychiatry. 2006;188:122–7.CrossRefPubMed Joukamaa M, Heliövaara M, Knekt P, Aromaa A, Raitasalo R, Lehtinen V. Schizophrenia, neuroleptic medication and mortality. Br J Psychiatry. 2006;188:122–7.CrossRefPubMed
26.
go back to reference Newcomer JW. Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. CNS Drugs. 2005;19 Suppl 1:1–93.PubMed Newcomer JW. Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. CNS Drugs. 2005;19 Suppl 1:1–93.PubMed
27.
go back to reference Hassan L, Birmingham L, Harty M, et al. Prospective cohort study of mental health during imprisonment. Br J Psychiatry. 2011;198:37–42.CrossRefPubMed Hassan L, Birmingham L, Harty M, et al. Prospective cohort study of mental health during imprisonment. Br J Psychiatry. 2011;198:37–42.CrossRefPubMed
28.
go back to reference Sim J. Medical power in prisons: the prison medical service in England 1774-1989. Buckingham: Open University Press; 1990. Sim J. Medical power in prisons: the prison medical service in England 1774-1989. Buckingham: Open University Press; 1990.
29.
go back to reference Young SJ, Adamou M, Bolea B, et al. The idnetification and management of ADHD offenders within the criminal justice system: a consensus statement from the UK Adult ADHD Network and criminal justice agencies. BMC Psychiatry. 2011;11:32.CrossRefPubMedPubMedCentral Young SJ, Adamou M, Bolea B, et al. The idnetification and management of ADHD offenders within the criminal justice system: a consensus statement from the UK Adult ADHD Network and criminal justice agencies. BMC Psychiatry. 2011;11:32.CrossRefPubMedPubMedCentral
31.
go back to reference Baker-Glenn E, Steels M, Evans C. Use of psychotropic medication among psychiatric out-patients with personality disorder. Psychiatrist. 2010;34:83–6.CrossRef Baker-Glenn E, Steels M, Evans C. Use of psychotropic medication among psychiatric out-patients with personality disorder. Psychiatrist. 2010;34:83–6.CrossRef
32.
go back to reference Griffiths EV, Willis J, Spark MJ. A systematic review of psychotropic drug prescribing for prisoners. Aust N Z J Psychiatry. 2012;46:407–21.CrossRefPubMed Griffiths EV, Willis J, Spark MJ. A systematic review of psychotropic drug prescribing for prisoners. Aust N Z J Psychiatry. 2012;46:407–21.CrossRefPubMed
Metadata
Title
Prevalence and appropriateness of psychotropic medication prescribing in a nationally representative cross-sectional survey of male and female prisoners in England
Authors
Lamiece Hassan
Jane Senior
Roger T. Webb
Martin Frisher
Mary P. Tully
David While
Jenny J. Shaw
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2016
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-016-1055-7

Other articles of this Issue 1/2016

BMC Psychiatry 1/2016 Go to the issue