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BMC Pediatrics
Published in: BMC Pediatrics 1/2024

Open Access 01-12-2024 | SARS-CoV-2 | Research

The footprint of SARS-COV-2 infection in neonatal late sepsis

Authors: Zahra Jamali, Najmeh Mohammadpour, Reza Sinaei, Maedeh Jafari, Fatemeh Sabzevari, Mohammad Hasannejad

Published in: BMC Pediatrics | Issue 1/2024

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Abstract

Background

Predicting and finding the viral agents responsible for neonatal late-sepsis has always been challenging.

Method

In this cross-sectional study, which has been done from September 2020 to December 2022, 145 hospitalized neonates suspected to late-onset sepsis alongside routine sepsis workup, were also evaluated for severe acute respiratory syndrome-coronavirus-2 (SARS-COV-2) infection, by nasopharyngeal real-time polymerase chain reaction (RT-PCR) or serological tests.

Result

145 neonates including 81 girls and 64 boys with a mean age of 12.3 ± 5.9 days and an average hospitalization stay of 23.1 ± 15.4 days were enrolled in the study. While 76.6% of them had negative bacterial culture, 63 patients (43.4%) showed evidence of SARS-COV-2 infection in RT-PCR or serology tests. None of the underlying factors including gender, age, and laboratory investigation had a significant relationship with SARS-COV-2 infection. Similarly, the outcomes of death and length of hospitalization were not different between the two groups with positive and negative SARS-COV-2 RT-PCR (P < 0.05). There was only a significant relationship between radiological changes including reticulonodular pattern, consolidation, pleural effusion, and different types of infiltrations and SARS-COV2 infection.

Conclusion

Considering the widespread of coronavirus disease 2019 (COVID-19) in newborns, it seems logical to investigate the SARS-COV-2 infection in late-sepsis.
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Metadata
Title
The footprint of SARS-COV-2 infection in neonatal late sepsis
Authors
Zahra Jamali
Najmeh Mohammadpour
Reza Sinaei
Maedeh Jafari
Fatemeh Sabzevari
Mohammad Hasannejad
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2024
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-024-04665-7

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