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BMC Ophthalmology

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Open Access 01-12-2023 | Retinal Detachment | Research article

Multimodal imaging of a micro-anatomical structure in the vitreous base

Authors: Liang Han, Zhizhong Ma

Published in: BMC Ophthalmology | Issue 1/2023

Abstract

Background

To describe an ultrastructure in the vitreous base (VB) and its micro-anatomical characteristics by multimodal imaging.

Methods

Light and transmission electron microscopy of the VB were performed on specimens from post-trauma eyes and one healthy donor eye. Intra-operative fundus images associated with VB abnormalities were captured from 4 cases, including 2 retinal detachment (RD) with PVR eyes and 2 post-trauma eyes. Images during micro-anatomical observation of the three specimens were analyzed along with the fundus images obtained during vitrectomy.

Results

Densely packed collagen fibers were observed by light microscopy between the pigment epithelium layer and uveal tissue within the ora serrata region in specimen 1 and the post-mortem healthy eye, respectively. A similar structure was also observed by transmission electron microscopy interior to the pigment epithelium layer and exposed to the vitreous cavity in specimen 2. The collagen fibers, which were termed ciliary body-choroid-retina (CB-C-R) connector, connects to the vitreous fibers interiorly, ciliary epithelium anteriorly, peripheral retina posteriorly, and uveal tissue exteriorly. The three different RD boundaries related to the posterior edge of the VB, ora serrata, and ciliary epithelium are demonstrated with the micro-anatomical characteristics of the CB-C-R connector.

Conclusion

The CB-C-R connector exists deep in the VB.

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Title: Multimodal imaging of a micro-anatomical structure in the vitreous base
Authors: Liang Han
Zhizhong Ma
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Retinal Detachment
Vitrectomy
Published in: BMC Ophthalmology / Issue 1/2023
Electronic ISSN: 1471-2415
DOI: https://doi.org/10.1186/s12886-023-03029-6

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Multimodal imaging of a micro-anatomical structure in the vitreous base

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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