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BMC Ophthalmology
Published in: BMC Ophthalmology 1/2020

01-12-2020 | Refractive Errors | Research article

Age distribution and associated factors of cornea biomechanical parameter stress-strain index in Chinese healthy population

Authors: Guihua Liu, Hua Rong, Ruxia Pei, Bei Du, Nan Jin, Di Wang, Chengcheng Jin, Ruihua Wei

Published in: BMC Ophthalmology | Issue 1/2020

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Abstract

Background

To investigate the new cornea biomechanical parameter stress-strain index (SSI) in Chinese healthy people and the factors associated with SSI.

Methods

A total of 175 eyes from 175 participants were included in this study. Axial length was measured with the Lenstar LS-900. Pentacam measured curvature of the cornea and anterior chamber volume (ACV). Cornea biomechanical properties assessments were performed by corneal visualization Scheimpflug technology (Corvis ST). Student’s t-test, one-way ANOVA, partial least square linear regression (PLSLR) and linear mixed effects (LME) model were used in the statistical analysis.

Results

The mean (±SD) SSI was 1.14 ± 0.22 (range, 0.66–1.78) in all subjects and affected by age significantly after age of 35 (P < 0.05). In LME models, SSI was significantly associated with age (β = 0.526, P < 0.001), axial length (AL) (β = − 0.541, P < 0.001), intraocular pressure (IOP) (β = 0.326, P < 0.001) and steepest radius of anterior corneal curvature (RsF) (β = 0.229, P < 0.001) but not with ACV, biomechanical corrected intraocular pressure (bIOP), flattest radius of anterior corneal curvature (RfF) or central corneal thickness (CCT) (P > 0.05 for each).

Conclusions

SSI increased with age after the age of 35. In addition to age, SSI was positively correlated with RsF and IOP, while negatively correlated with AL.
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Metadata
Title
Age distribution and associated factors of cornea biomechanical parameter stress-strain index in Chinese healthy population
Authors
Guihua Liu
Hua Rong
Ruxia Pei
Bei Du
Nan Jin
Di Wang
Chengcheng Jin
Ruihua Wei
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Ophthalmology / Issue 1/2020
Electronic ISSN: 1471-2415
DOI
https://doi.org/10.1186/s12886-020-01704-6

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