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BMC Ophthalmology

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Open Access 01-12-2018 | Research article

Heritability of myopia and its relation with GDJ2 and RASGRF1 genes in Lithuania

Authors: Edita Kunceviciene, Margarita Sriubiene, Rasa Liutkeviciene, Ilona T. Miceikiene, Alina Smalinskiene

Published in: BMC Ophthalmology | Issue 1/2018

Abstract

Background

This study aimed to assess heritability of myopia in Lithuania and evaluate both genes GJD2 (Gap Junction Protein, Delta 2) and RASGRF1 (RAS protein-specific guanine nucleotide-releasing factor 1) relation with myopia.

Methods

In this study Lithuanian twin population aged between 18 and 40 (n = 460) were examined. Single-nucleotide polymorphisms of the RASGRF1 (rs8027411) and GJD2 (rs634990) genes were assessed by real-time polymerase chain reaction method.

Results

Intrapair correlations for spherical equivalent in all twin pairs were significantly higher in MZ twin pairs r = 0.539 (p < 0.001, 95% CI 0.353–0.684) than in DZ twin pairs r = 0.203 (p < 0.01, 95% CI 0.0633–0.442) in myopia group. Correlations for spherical equivalent in emmetropia group were not significant in MZ twin pairs r = 0.091 (p > 0.05, 95% CI -0.215-0.381) and in DZ twin pairs r = − 0.220 (p > 0.05, 95% CI -0.587-0.222). The odds ratio (95% CI) were 2.7 (1.018–7.460) for combinations of genotypes of rs634990 CC and rs8027411 GT (p = 0.046).

Conclusions

Our studies have shown that the heritability of myopia makes 67.2% in Lithuania. Persons with combinations of genotypes rs634990 CC and rs8027411 GT have 2.7 times higher odds to have myopia.

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Title: Heritability of myopia and its relation with GDJ2 and RASGRF1 genes in Lithuania
Authors: Edita Kunceviciene
Margarita Sriubiene
Rasa Liutkeviciene
Ilona T. Miceikiene
Alina Smalinskiene
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: BMC Ophthalmology / Issue 1/2018
Electronic ISSN: 1471-2415
DOI: https://doi.org/10.1186/s12886-018-0787-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Heritability of myopia and its relation with GDJ2 and RASGRF1 genes in Lithuania

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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