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Open Access 01-12-2023 | Esophageal Cancer | Research

Effects of preoperative albumin-to-globulin ratio on overall survival and quality of life in esophageal cell squamous carcinoma patients: a prospective cohort study

Authors: Juwei Zhang, Zheng Lin, Jinsong Zhou, Yue Huang, Siting Chen, Yuan Deng, Minglian Qiu, Yuanmei Chen, Zhijian Hu

Published in: BMC Cancer | Issue 1/2023

Abstract

Objective

This study aimed to investigate the effect of preoperative albumin-to-globulin ratio (AGR) on overall survival (OS) and health-related quality of life in patients with esophageal cell squamous carcinoma (ESCC).

Methods

Serum albumin and globulin were measured within one week before surgery. Multiple follow-ups were conducted among patients with ESCC in the study in order to assess their life quality. The method used in the study was a telephone interview. Quality of life was measured using the EORTC Quality of Life Questionnaire-Core Questionnaire (EORTC QLQ-C30, version 3.0) and Esophageal Cancer Module (EORTC QLQ- OES18).

Results

A total of 571 ESCC patients were included in the study. The results illustrated that 5-year OS of high AGR group (74.3%) was better than the low one (62.3%) (P = 0.0068). Univariate and multivariate Cox regression analysis found that preoperative AGR (HR = 0.642, 95%CI: 0.444–0.927) are prognostic factor for patients with ESCC after surgery. In terms of quality of life, found that low AGR associated with increased postoperative time to deterioration (TTD) events in ESCC patients, and compared to low AGR, high AGR could delay the deterioration of emotional functioning(P = 0.001), dysphagia(P = 0.033), trouble with taste(P = 0.043) and speech problems(P = 0.043). After using the multivariate Cox regression analysis showed that high AGR could improve patients’ emotional function (HR = 0.657, 95% CI: 0.507–0.852) and trouble with taste (HR = 0.706, 95% CI: 0.514–0.971).

Conclusions

Preoperative AGR in patients with ESCC after esophagectomy was positively correlated with overall survival rate and quality of life after operation.

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Title: Effects of preoperative albumin-to-globulin ratio on overall survival and quality of life in esophageal cell squamous carcinoma patients: a prospective cohort study
Authors: Juwei Zhang
Zheng Lin
Jinsong Zhou
Yue Huang
Siting Chen
Yuan Deng
Minglian Qiu
Yuanmei Chen
Zhijian Hu
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Esophageal Cancer
Esophageal Cancer
Dysphagia
Dysphagia
Dysphagia
Published in: BMC Cancer / Issue 1/2023
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-023-10809-2

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Abstract

Objective

Methods

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Conclusions

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