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Open Access 01-12-2018 | Research article

The SBRT database initiative of the German Society for Radiation Oncology (DEGRO): patterns of care and outcome analysis of stereotactic body radiotherapy (SBRT) for liver oligometastases in 474 patients with 623 metastases

Authors: N. Andratschke, H. Alheid, M. Allgäuer, G. Becker, O. Blanck, J. Boda-Heggemann, T. Brunner, M. Duma, S. Gerum, M. Guckenberger, G. Hildebrandt, R. J. Klement, V. Lewitzki, C. Ostheimer, A. Papachristofilou, C. Petersen, T. Schneider, R. Semrau, S. Wachter, D. Habermehl

Published in: BMC Cancer | Issue 1/2018

Excerpt

Stereotactic body radiation therapy (SBRT) is a dedicated form of external beam radiotherapy which is characterized by a steep dose gradient outside the irradiated tumor volume while escalating the dose inside the target volume. Combined with high precision patient setup and image guidance, this is a highly effective local treatment while achieving a very low toxicity profile. Usually, treatment protocols include higher single doses and the fraction number ranges from a radiosurgery (1 fraction) procedure up to 10 fractions. …

Timmerman R. Stereotactic body radiation therapy for inoperable early stage lung cancer. JAMA. 2010;303:1070. https://doi.org/10.1001/jama.2010.261.CrossRefPubMedPubMedCentral

Hellman S, Weichselbaum RR. Oligometastases. J Clin Oncol. 1995;13:8–10. https://doi.org/10.1200/JCO.1995.13.1.8.CrossRefPubMed

Tree AC, Khoo VS, Eeles RA, Ahmed M, Dearnaley DP, Hawkins MA, Huddart RA, Nutting CM, Ostler PJ, van As NJ. Stereotactic body radiotherapy for oligometastases. Lancet Oncol. 2013;14:e28–37. https://doi.org/10.1016/S1470-2045(12)70510-7.CrossRefPubMed

Niibe Y, Hayakawa K. Oligometastases and oligo-recurrence: the new era of cancer therapy. Jpn J Clin Oncol. 2010;40:107–11. https://doi.org/10.1093/jjco/hyp167.CrossRefPubMedPubMedCentral

Niibe Y, Yamashita H, Sekiguchi K, Takahashi W, Shiraishi K, Okuma K, Terahara A, Kawamori J, Nakagawa K. Stereotactic body radiotherapy results for pulmonary Oligometastases: a two-institution collaborative investigation. Anticancer Res. 2015;35:4903–8.PubMed

Andratschke NH, Nieder C, Heppt F, Molls M, Zimmermann F. Stereotactic radiation therapy for liver metastases: factors affecting local control and survival. Radiat Oncol. 2015;10:287. https://doi.org/10.1186/s13014-015-0369-9.CrossRef

Herfarth KK, Debus J, Lohr F, Bahner ML, Rhein B, Fritz P, Höss A, Schlegel W, Wannenmacher MF. Stereotactic single-dose radiation therapy of liver tumors: results of a phase I/II trial. J Clin Oncol. 2001;19:164–70.CrossRefPubMed

Katz AW, Carey-Sampson M, Muhs AG, Milano MT, Schell MC, Okunieff P. Hypofractionated stereotactic body radiation therapy (SBRT) for limited hepatic metastases. Int J Radiat Oncol Biol Phys. 2007;67:793–8. https://doi.org/10.1016/j.ijrobp.2006.10.025.CrossRefPubMed

Scorsetti M, Clerici E, Comito T. Stereotactic body radiation therapy for liver metastases. J Gastrointest Oncol. 2014;5:190–7. https://doi.org/10.3978/j.issn.2078-6891.2014.039.PubMedPubMedCentral

10.

Vautravers-Dewas C, Dewas S, Bonodeau F, Adenis A, Lacornerie T, Penel N, Lartigau E, Mirabel X. Image-guided robotic stereotactic body radiation therapy for liver metastases: is there a dose response relationship? Int J Radiat Oncol Biol Phys. 2011;81:e39–47. https://doi.org/10.1016/j.ijrobp.2010.12.047.CrossRefPubMed

11.

Lee MT, Kim JJ, Dinniwell R, Brierley J, Lockwood G, Wong R, Cummings B, Ringash J, Tse RV, Knox JJ, Dawson LA. Phase I study of individualized stereotactic body radiotherapy of liver metastases. J Clin Oncol. 2009;27:1585–91. https://doi.org/10.1200/JCO.2008.20.0600.CrossRefPubMed

12.

Wulf J, Guckenberger M, Haedinger U, Oppitz U, Mueller G, Baier K, Flentje M. Stereotactic radiotherapy of primary liver cancer and hepatic metastases. Acta Oncol. 2006;45:838–47. https://doi.org/10.1080/02841860600904821.CrossRefPubMed

13.

Klement RJ. Radiobiological parameters of liver and lung metastases derived from tumor control data of 3719 metastases. Radiother Oncol. 2017;123:218–26. https://doi.org/10.1016/j.radonc.2017.03.014.CrossRefPubMed

14.

Sterzing F, Brunner TB, Ernst I, Baus WW, Greve B, Herfarth K, Guckenberger M. Stereotactic body radiotherapy for liver tumors: principles and practical guidelines of the DEGRO working group on stereotactic radiotherapy. Strahlenther Onkol. 2014;190:872–81. https://doi.org/10.1007/s00066-014-0714-1.CrossRefPubMed

15.

Van Cutsem E, Cervantes A, Adam R, Sobrero A, Van Krieken JH, Aderka D, Aranda Aguilar E, Bardelli A, Benson A, Bodoky G, Ciardiello F, D'Hoore A, Diaz-Rubio E, Douillard J-Y, Ducreux M, Falcone A, Grothey A, Gruenberger T, Haustermans K, Heinemann V, Hoff P, Köhne C-H, Labianca R, Laurent-Puig P, Ma B, Maughan T, Muro K, Normanno N, Osterlund P, Oyen WJG, Papamichael D, Pentheroudakis G, Pfeiffer P, Price TJ, Punt C, Ricke J, Roth A, Salazar R, Scheithauer W, Schmoll HJ, Tabernero J, Taïeb J, Tejpar S, Wasan H, Yoshino T, Zaanan A, ARNOLD D. ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. Ann Oncol. 2016;27:1386–422. https://doi.org/10.1093/annonc/mdw235.CrossRefPubMed

16.

Klement RJ, Guckenberger M, Alheid H, Allgäuer M, Becker G, Blanck O, Boda-Heggemann J, Brunner T, Duma M, Gerum S, Habermehl D, Hildebrandt G, Lewitzki V, Ostheimer C, Papachristofilou A, Petersen C, Schneider T, Semrau R, Wachter S, Andratschke N. Stereotactic body radiotherapy for oligo-metastatic liver disease - influence of pre-treatment chemotherapy and histology on local tumor control. Radiother Oncol. 2017; https://doi.org/10.1016/j.radonc.2017.01.013.

17.

Rusthoven KE, Kavanagh BD, Cardenes H, Stieber VW, Burri SH, Feigenberg SJ, Chidel MA, Pugh TJ, Franklin W, Kane M, Gaspar LE, Schefter TE. Multi-institutional phase I/II trial of stereotactic body radiation therapy for liver metastases. J Clin Oncol. 2009;27:1572–8. https://doi.org/10.1200/JCO.2008.19.6329.CrossRefPubMed

18.

Iyengar P, Wardak Z, Gerber DE, Tumati V, Ahn C, Hughes RS, Dowell JE, Cheedella N, Nedzi L, Westover KD, Pulipparacharuvil S, Choy H, Timmerman RD. Consolidative radiotherapy for limited metastatic non-small-cell lung cancer: a phase 2 randomized clinical trial. JAMA Oncol. 2018;4:e173501. https://doi.org/10.1001/jamaoncol.2017.3501.CrossRefPubMed

19.

Gomez DR, Blumenschein GR, Lee JJ, Hernandez M, Ye R, Camidge DR, Doebele RC, Skoulidis F, Gaspar LE, Gibbons DL, Karam JA, Kavanagh BD, Tang C, Komaki R, Louie AV, Palma DA, Tsao AS, Sepesi B, William WN, Zhang J, Shi Q, Wang X-S, Swisher SG, Heymach JV. Local consolidative therapy versus maintenance therapy or observation for patients with oligometastatic non-small-cell lung cancer without progression after first-line systemic therapy: a multicentre, randomised, controlled, phase 2 study. Lancet Oncol. 2016;17:1672–82. https://doi.org/10.1016/S1470-2045(16)30532-0.CrossRefPubMedPubMedCentral

20.

Ruers T, Punt CJA, van Coevorden F, Pierie JP, Borel Rinkes I, Ledermann J, Poston G, Bechstein W, Lentz MA, Mauer M, Van Cutsem E, Lutz M, Nordlinger B. O-018 * Radiofrequency ablation (RFA) combined with chemotherapy for unresectable colorectal liver metastases (CRC LM): Long-term survival results of a randomised phase II study of the EORTC-NCRI CCSG-ALM Intergroup 40004 (CLOCC). Ann Oncol. 2015;26:iv114–5. https://doi.org/10.1093/annonc/mdv235.17.CrossRef

21.

Guckenberger M, Klement RJ, Allgäuer M, Andratschke N, Blanck O, Boda-Heggemann J, Dieckmann K, Duma M, Ernst I, Ganswindt U, Hass P, Henkenberens C, Holy R, Imhoff D, Kahl HK, Krempien R, Lohaus F, Nestle U, Nevinny-Stickel M, Petersen C, Semrau S, Streblow J, Wendt TG, Wittig A, Flentje M, Sterzing F. Local tumor control probability modeling of primary and secondary lung tumors in stereotactic body radiotherapy. Radiother Oncol. 2015;0:485–91. https://doi.org/10.1016/j.radonc.2015.09.008.

22.

Schefter TE, Kavanagh BD, Timmerman RD, Cardenes HR, Baron A, Gaspar LE. A phase I trial of stereotactic body radiation therapy (SBRT) for liver metastases. Int J Radiat Oncol Biol Phys. 2005;62:1371–8. https://doi.org/10.1016/j.ijrobp.2005.01.002.CrossRefPubMed

23.

Swaminath A, Massey C, Brierley JD, Dinniwell R, Wong R, Kim JJ, Velec M, Brock KK, Dawson LA. Accumulated delivered dose response of stereotactic body radiation therapy for liver metastases. Radiat Oncol Biol. 2015;93:639–48. https://doi.org/10.1016/j.ijrobp.2015.07.2273.CrossRef

24.

Høyer M, Swaminath A, Bydder S, Lock M, Méndez Romero A, Kavanagh B, Goodman KA, Okunieff P, Dawson LA. Radiotherapy for liver metastases: a review of evidence. Int J Radiat Oncol Biol Phys. 2012;82:1047–57. https://doi.org/10.1016/j.ijrobp.2011.07.020.CrossRefPubMed

25.

Chang EL, Shiu AS, Mendel E, Mathews LA, Mahajan A, Allen PK, Weinberg JS, Brown BW, Wang XS, Woo SY, Cleeland C, Maor MH, Rhines LD. Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure. J Neurosurg Spine. 2007;7:151–60. https://doi.org/10.3171/SPI-07/08/151.CrossRefPubMed

26.

Goodman KA, Wiegner EA, Maturen KE, Zhang Z, Mo Q, Yang G, Gibbs IC, Fisher GA, Koong AC. Dose-escalation study of single-fraction stereotactic body radiotherapy for liver malignancies. Int J Radiat Oncol Biol Phys. 2010;78:486–93. https://doi.org/10.1016/j.ijrobp.2009.08.020.CrossRefPubMed

27.

Stintzing S, Hoffmann R-T, Heinemann V, Kufeld M, Rentsch M, Muacevic A. Radiosurgery of liver tumors: value of robotic Radiosurgical device to treat liver tumors. Ann Surg Oncol. 2010;17:2877–83. https://doi.org/10.1245/s10434-010-1187-9.CrossRefPubMed

28.

Scorsetti M, Comito T, Tozzi A, Navarria P, Fogliata A, Clerici E, Mancosu P, Reggiori G, Rimassa L, Torzilli G, Tomatis S, Santoro A, Cozzi L. Final results of a phase II trial for stereotactic body radiation therapy for patients with inoperable liver metastases from colorectal cancer. J Cancer Res Clin Oncol. 2015;141:543–53. https://doi.org/10.1007/s00432-014-1833-x.CrossRefPubMed

29.

Fode MM, Høyer M. Survival and prognostic factors in 321 patients treated with stereotactic body radiotherapy for oligo-metastases. Radiother Oncol. 2015;114:155–60. https://doi.org/10.1016/j.radonc.2014.12.003.CrossRefPubMed

Title: The SBRT database initiative of the German Society for Radiation Oncology (DEGRO): patterns of care and outcome analysis of stereotactic body radiotherapy (SBRT) for liver oligometastases in 474 patients with 623 metastases
Authors: N. Andratschke
H. Alheid
M. Allgäuer
G. Becker
O. Blanck
J. Boda-Heggemann
T. Brunner
M. Duma
S. Gerum
M. Guckenberger
G. Hildebrandt
R. J. Klement
V. Lewitzki
C. Ostheimer
A. Papachristofilou
C. Petersen
T. Schneider
R. Semrau
S. Wachter
D. Habermehl
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: BMC Cancer / Issue 1/2018
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-018-4191-2

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