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BMC Cancer

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Open Access 01-12-2016 | Research article

Decreased expression of stomatin predicts poor prognosis in HER2-positive breast cancer

Authors: Chin-Yau Chen, Chih-Yung Yang, Yen-Chung Chen, Chia-Wen Shih, Su-Shun Lo, Chi-Hung Lin

Published in: BMC Cancer | Issue 1/2016

Abstract

Background

Human epidermal growth factor receptor-2 (HER2) is a transmembrane tyrosine kinase receptor that is overexpressed in 25 to 30 % of human breast cancers and is preferentially localized in lipid rafts. Stomatin is a membrane protein that is absent from the erythrocyte plasma membrane in patients with congenital stomatocytosis and is the major component of the lipid raft.

Results

In a total of 68 clinical cases of HER2-positive breast cancer, the absence of stomatin expression was associated with a decreased 5-year survival (65 % vs. 93 %, p = 0.005) by survival analysis. For stage I-III HER2-positive breast cancer, the absence of stomatin expression was associated with a decreased 5-year disease-free survival (57 % vs. 81 %, p = 0.016) and was an independent prognostic factor by multivariate analysis. Negative stomatin expression predicts distant metastases in a hazard ratio of 4.0 (95 % confidence interval from 1.3 to 12.5).

Conclusions

These results may suggest that stomatin is a new prognostic indicator for HER2-positive breast cancer.

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Title: Decreased expression of stomatin predicts poor prognosis in HER2-positive breast cancer
Authors: Chin-Yau Chen
Chih-Yung Yang
Yen-Chung Chen
Chia-Wen Shih
Su-Shun Lo
Chi-Hung Lin
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: BMC Cancer / Issue 1/2016
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-016-2681-7

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