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BMC Pregnancy and Childbirth

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Open Access 01-12-2023 | Gastric Cancer | Case report

Prenatal diagnosis of hereditary diffuse gastric cancer: a case report

Authors: Jun Xiao, Hui Li, Fenggui Xue, Zhifei Luo, Yanyang Pang

Published in: BMC Pregnancy and Childbirth | Issue 1/2023

Abstract

Background

Hereditary diffuse gastric cancer(HDGC) is a kind of malignant gastric cancer that is difficult to find in the early stage. However, this late onset and incomplete penetrance hereditary cancer, and its prenatal diagnosis have rarely been reported previously.

Case presentation

A 26-year-old woman was referred to genetic counseling for an ultrasonography of fetal choroid plexus cyst at 17 weeks of gestation. The ultrasonographic evaluation showed bilateral choroid plexus cysts(CPC) in the lateral ventricles, and the women showed a family history of gastric cancer and breast cancer. Trio copy number sequencing identified a pathogenic CDH1 deletion in the fetus and unaffected mother. The CDH1 deletion was found in three of the five family members tested, segregation among affected family members. The couple finally decided to terminate the pregnancy after genetic counseling by hospital geneticists due to the uncertainty of the occurrence of HDGC in the future.

Conclusions

In prenatal diagnosis, a family history of cancer should be widely concerned, and prenatal diagnosis of hereditary tumors requires extensive cooperation between the prenatal diagnosis structure and the pathology department.

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Title: Prenatal diagnosis of hereditary diffuse gastric cancer: a case report
Authors: Jun Xiao
Hui Li
Fenggui Xue
Zhifei Luo
Yanyang Pang
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Gastric Cancer
Gastric Cancer
Breast Cancer
Breast Cancer
Published in: BMC Pregnancy and Childbirth / Issue 1/2023
Electronic ISSN: 1471-2393
DOI: https://doi.org/10.1186/s12884-023-05772-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prenatal diagnosis of hereditary diffuse gastric cancer: a case report

Abstract

Background

Case presentation

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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