Skip to main content
Top
Published in: BMC Pregnancy and Childbirth 1/2019

Open Access 01-12-2019 | Research article

Factors associated with perinatal mortality in Nepal: evidence from Nepal demographic and health survey 2001–2016

Authors: Pramesh Raj Ghimire, Kingsley E. Agho, Andre M. N. Renzaho, Monjura K. Nisha, Michael Dibley, Camille Raynes-Greenow

Published in: BMC Pregnancy and Childbirth | Issue 1/2019

Login to get access

Abstract

Background

Perinatal mortality is a devastating pregnancy outcome affecting millions of families in many low and middle-income countries including Nepal. This paper examined the more distant factors associated with perinatal mortality in Nepal.

Methods

A sample of 23,335 pregnancies > 28 weeks’ gestation from the Nepal Demographic and Health Survey datasets for the period (2001–2016) was analysed. Perinatal Mortality (PM) is defined as the sum of stillbirth (fetal deaths in pregnancies > 28 weeks’ gestation) and early neonatal mortality (deaths within the first week of life), while Extended Perinatal Mortality (EPM) is denoted as the sum of stillbirth and neonatal mortality (deaths within the first 28 days of life). Rates of PM and EPM were calculated. Logistic regression generalized linear latent and mixed models (GLLAMM) that adjusted for clustering and sampling weight was used to examine the factor associated with perinatal mortality.

Results

Over the study period, the PMR was 42 [95% Confidence Interval (CI): 39, 44] per 1000 births for the five-year before each survey; while corresponding EPMR was 49 (95% CI, 46, 51) per 1000 births. Multivariable analyses revealed that women residing in the mountains, who did not use contraceptives, women aged 15–18 years or 19–24 years, and women having no education were associated with increased PM and EPM. The study also identified households using biomass as cooking fuel, and households who reported unimproved sanitation or open defecation were significantly more likely to experience PM and EPM.

Conclusions

Interventions aimed to improve use of contraceptives, and reduce biomass as a source of cooking fuel are needed to achieve the recommended target of < 12 perinatal deaths per 1000 births by 2030.
Appendix
Available only for authorised users
Literature
1.
go back to reference World Health Organization. Neonatal and perinatal mortality: country, regional and global estimates. Geneva: WHO; 2006. World Health Organization. Neonatal and perinatal mortality: country, regional and global estimates. Geneva: WHO; 2006.
2.
go back to reference Wang H, Bhutta ZA, Coates MM, Coggeshall M, Dandona L, Diallo K, et al. Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1725.CrossRef Wang H, Bhutta ZA, Coates MM, Coggeshall M, Dandona L, Diallo K, et al. Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1725.CrossRef
3.
go back to reference Mason E, McDougall L, Lawn JE, Gupta A, Claeson M, Pillay Y, et al. From evidence to action to deliver a healthy start for the next generation. Lancet. 2014;384:455–67.CrossRef Mason E, McDougall L, Lawn JE, Gupta A, Claeson M, Pillay Y, et al. From evidence to action to deliver a healthy start for the next generation. Lancet. 2014;384:455–67.CrossRef
4.
go back to reference Bhutta ZA, Das JK, Bahl R, Lawn JE, Salam RA, Paul VK, et al. Can available interventions end preventable deaths in mothers, newborn babies, and stillbirths, and at what cost? Lancet. 2014;384:347–70.CrossRef Bhutta ZA, Das JK, Bahl R, Lawn JE, Salam RA, Paul VK, et al. Can available interventions end preventable deaths in mothers, newborn babies, and stillbirths, and at what cost? Lancet. 2014;384:347–70.CrossRef
5.
go back to reference Fikree FF, Gray RH. Demographic survey of the level and determinants of perinatal mortality in Karachi, Pakistan. Paediatr Perinat Epidemiol. 1996;10:86–96.CrossRef Fikree FF, Gray RH. Demographic survey of the level and determinants of perinatal mortality in Karachi, Pakistan. Paediatr Perinat Epidemiol. 1996;10:86–96.CrossRef
6.
go back to reference Khan MN, Rahman MM, Shariff AA, Rahman MM, Rahman MS, Rahman MA. Maternal undernutrition and excessive body weight and risk of birth and health outcomes. Arch Public Health. 2017;75:12.CrossRef Khan MN, Rahman MM, Shariff AA, Rahman MM, Rahman MS, Rahman MA. Maternal undernutrition and excessive body weight and risk of birth and health outcomes. Arch Public Health. 2017;75:12.CrossRef
7.
go back to reference Manandhar DS, Osrin D, Shrestha BP, Mesko N, Morrison J, Tumbahangphe KM, et al. Effect of a participatory intervention with women's groups on birth outcomes in Nepal: cluster-randomised controlled trial. Lancet. 2004;364:970–9.CrossRef Manandhar DS, Osrin D, Shrestha BP, Mesko N, Morrison J, Tumbahangphe KM, et al. Effect of a participatory intervention with women's groups on birth outcomes in Nepal: cluster-randomised controlled trial. Lancet. 2004;364:970–9.CrossRef
8.
go back to reference Manandhar SR, Ojha A, Manandhar DS, Shrestha B, Shrestha D, Saville N, et al. Causes of stillbirths and neonatal deaths in Dhanusha district, Nepal: a verbal autopsy study. Kathmandu Univ Med J (KUMJ). 2010;8:62–72.CrossRef Manandhar SR, Ojha A, Manandhar DS, Shrestha B, Shrestha D, Saville N, et al. Causes of stillbirths and neonatal deaths in Dhanusha district, Nepal: a verbal autopsy study. Kathmandu Univ Med J (KUMJ). 2010;8:62–72.CrossRef
9.
go back to reference Geetha T, Chenoy R, Stevens D, Johanson R. A multicentre study of perinatal mortality in Nepal. Paediatr Perinat Epidemiol. 1995;9:74–89.CrossRef Geetha T, Chenoy R, Stevens D, Johanson R. A multicentre study of perinatal mortality in Nepal. Paediatr Perinat Epidemiol. 1995;9:74–89.CrossRef
10.
go back to reference Suwal A. Obstetric and perinatal outcome of teenage pregnancy. JNHRC. 2012;10:52–6. Suwal A. Obstetric and perinatal outcome of teenage pregnancy. JNHRC. 2012;10:52–6.
11.
go back to reference Shrestha M, Manandhar D, Dhakal S, Nepal N. Two year audit of perinatal mortality at Kathmandu medical college teaching hospital. Kathmandu Univ Med J. 2006;4:176–81. Shrestha M, Manandhar D, Dhakal S, Nepal N. Two year audit of perinatal mortality at Kathmandu medical college teaching hospital. Kathmandu Univ Med J. 2006;4:176–81.
12.
go back to reference Ministry of Health [Nepal], New ERA, and ORC Macro. 2002. Nepal Demographic and Health Survey 2001. Calverton, Maryland, USA: Family Health Division, Ministry of Health; New ERA; and ORC Macro. Ministry of Health [Nepal], New ERA, and ORC Macro. 2002. Nepal Demographic and Health Survey 2001. Calverton, Maryland, USA: Family Health Division, Ministry of Health; New ERA; and ORC Macro.
13.
go back to reference Ministry of Health and Population (MOHP) [Nepal], New ERA, and Macro International Inc. 2007. Nepal Demographic and Health Survey 2006. Kathmandu, Nepal: Ministry of Health and Population, New ERA, and Macro International Inc. Ministry of Health and Population (MOHP) [Nepal], New ERA, and Macro International Inc. 2007. Nepal Demographic and Health Survey 2006. Kathmandu, Nepal: Ministry of Health and Population, New ERA, and Macro International Inc.
14.
go back to reference Ministry of Health and Population (MOHP) [Nepal], New ERA, and ICF International Inc. 2012. Nepal Demographic and Health Survey 2011. Kathmandu, Nepal: Ministry of Health and Population, New ERA, and ICF International, Calverton, Maryland. Ministry of Health and Population (MOHP) [Nepal], New ERA, and ICF International Inc. 2012. Nepal Demographic and Health Survey 2011. Kathmandu, Nepal: Ministry of Health and Population, New ERA, and ICF International, Calverton, Maryland.
15.
go back to reference Ministry of Health and Population (MOHP) [Nepal], New ERA, and ICF International Inc. 2017. Nepal Demographic and Health Survey 2016. Kathmandu, Nepal: Ministry of Health and Population, New ERA, and ICF International, Calverton, Maryland. Ministry of Health and Population (MOHP) [Nepal], New ERA, and ICF International Inc. 2017. Nepal Demographic and Health Survey 2016. Kathmandu, Nepal: Ministry of Health and Population, New ERA, and ICF International, Calverton, Maryland.
16.
go back to reference Neasham D, Dolk H, Vrijheid M, Jensen T, Best N. Stillbirth and neonatal mortality due to congenital anomalies: temporal trends and variation by small area deprivation scores in England and Wales, 1986–96. Paediatr Perinat Epidemiol. 2001;15:364–73.CrossRef Neasham D, Dolk H, Vrijheid M, Jensen T, Best N. Stillbirth and neonatal mortality due to congenital anomalies: temporal trends and variation by small area deprivation scores in England and Wales, 1986–96. Paediatr Perinat Epidemiol. 2001;15:364–73.CrossRef
17.
go back to reference Ghimire PR, Agho K, Akombi B, Wali N, Dibley M, Raynes-Greenow C, et al. Perinatal mortality in South Asia: systematic review of observational studies. Int J Environ Res. 2018;15:1428. Ghimire PR, Agho K, Akombi B, Wali N, Dibley M, Raynes-Greenow C, et al. Perinatal mortality in South Asia: systematic review of observational studies. Int J Environ Res. 2018;15:1428.
18.
go back to reference Nisha MK, Alam A, Raynes-Greenow C. Variations in perinatal mortality associated with different polluting fuel types and kitchen location in Bangladesh. Int J Occup Environ Health. 2018;24:47–54. Nisha MK, Alam A, Raynes-Greenow C. Variations in perinatal mortality associated with different polluting fuel types and kitchen location in Bangladesh. Int J Occup Environ Health. 2018;24:47–54.
19.
go back to reference Andargie G, Berhane Y, Worku A, Kebede Y. Predictors of perinatal mortality in rural population of Northwest Ethiopia: a prospective longitudinal study. BMC Public Health. 2013;13:168.CrossRef Andargie G, Berhane Y, Worku A, Kebede Y. Predictors of perinatal mortality in rural population of Northwest Ethiopia: a prospective longitudinal study. BMC Public Health. 2013;13:168.CrossRef
20.
go back to reference Mosley WH, Chen LC. An analytical framework for the study of child survival in developing countries. Popul Dev Rev. 1984;10:25–45.CrossRef Mosley WH, Chen LC. An analytical framework for the study of child survival in developing countries. Popul Dev Rev. 1984;10:25–45.CrossRef
21.
go back to reference Abir T, Agho KE, Ogbo FA, Stevens GJ, Page A, Hasant MA, et al. Predictors of stillbirths in Bangladesh: evidence from the 2004–2014 nation-wide household surveys. Glob Health Action. 2017;10:1410048.CrossRef Abir T, Agho KE, Ogbo FA, Stevens GJ, Page A, Hasant MA, et al. Predictors of stillbirths in Bangladesh: evidence from the 2004–2014 nation-wide household surveys. Glob Health Action. 2017;10:1410048.CrossRef
22.
go back to reference Filmer D, Pritchett LH. Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. Demography. 2001;38:115–32.PubMed Filmer D, Pritchett LH. Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. Demography. 2001;38:115–32.PubMed
23.
go back to reference UNICEF/WHO. Progress on Sanitation and Drinking-Water: 2015 Update and MDG assessment. Geneva: UNICEF/WHO; 2015. UNICEF/WHO. Progress on Sanitation and Drinking-Water: 2015 Update and MDG assessment. Geneva: UNICEF/WHO; 2015.
24.
go back to reference Skrondal A, Rabe-Hesketh S. Generalized latent variable modeling: multilevel, longitudinal, and structural equation models. Chapman and Hall/CRC; 2004. Skrondal A, Rabe-Hesketh S. Generalized latent variable modeling: multilevel, longitudinal, and structural equation models. Chapman and Hall/CRC; 2004.
25.
go back to reference Victora CG, Huttly SR, Fuchs SC, Olinto M. The role of conceptual frameworks in epidemiological analysis: a hierarchical approach. Int J Epidemiol. 1997;26:224–7.CrossRef Victora CG, Huttly SR, Fuchs SC, Olinto M. The role of conceptual frameworks in epidemiological analysis: a hierarchical approach. Int J Epidemiol. 1997;26:224–7.CrossRef
26.
go back to reference Gonzales GF, Tapia V, Carrillo CE. Stillbirth rates in Peruvian populations at high altitude. Int J Gynaecol Obstet. 2008;100:221–7.CrossRef Gonzales GF, Tapia V, Carrillo CE. Stillbirth rates in Peruvian populations at high altitude. Int J Gynaecol Obstet. 2008;100:221–7.CrossRef
27.
go back to reference Ghimire PR, Agho KE, Renzaho A, Christou A, Nisha MK, Dibley M, et al. Socio-economic predictors of stillbirths in Nepal (2001-2011). PLoS One. 2017;12:e0181332.CrossRef Ghimire PR, Agho KE, Renzaho A, Christou A, Nisha MK, Dibley M, et al. Socio-economic predictors of stillbirths in Nepal (2001-2011). PLoS One. 2017;12:e0181332.CrossRef
28.
go back to reference Tachiweyika E, Gombe N, Shambira G, Chadambuka A, Mufuta T, Zizhou S. Determinants of perinatal mortality in Marondera district, Mashonaland East Province of Zimbabwe, 2009: a case control study. Pan Afr Med J. 2011;8:7.CrossRef Tachiweyika E, Gombe N, Shambira G, Chadambuka A, Mufuta T, Zizhou S. Determinants of perinatal mortality in Marondera district, Mashonaland East Province of Zimbabwe, 2009: a case control study. Pan Afr Med J. 2011;8:7.CrossRef
29.
go back to reference Bari W, Chowdhury RI, Islam MA, Chakraborty N, Akhter HA. The differentials and determinants of perinatal mortality in rural Bangladesh. Eur J Contracept Reprod Health Care. 2002;7:216–22.CrossRef Bari W, Chowdhury RI, Islam MA, Chakraborty N, Akhter HA. The differentials and determinants of perinatal mortality in rural Bangladesh. Eur J Contracept Reprod Health Care. 2002;7:216–22.CrossRef
30.
go back to reference Yirgu R, Molla M, Sibley L, Gebremariam A. Perinatal mortality magnitude, determinants and causes in west Gojam: population-based nested case-control study. PLoS One. 2016;11:e0159390.CrossRef Yirgu R, Molla M, Sibley L, Gebremariam A. Perinatal mortality magnitude, determinants and causes in west Gojam: population-based nested case-control study. PLoS One. 2016;11:e0159390.CrossRef
31.
go back to reference Sharma AK, Verma K, Khatri S, Kannan A. Determinants of pregnancy in adolescents in Nepal. Indian J Pediatr. 2002;69:19–22.CrossRef Sharma AK, Verma K, Khatri S, Kannan A. Determinants of pregnancy in adolescents in Nepal. Indian J Pediatr. 2002;69:19–22.CrossRef
32.
go back to reference Choe MK, Thapa S, Mishra V. Early marriage and early motherhood in Nepal. J Biosoc Sci. 2005;37:143–62.CrossRef Choe MK, Thapa S, Mishra V. Early marriage and early motherhood in Nepal. J Biosoc Sci. 2005;37:143–62.CrossRef
33.
go back to reference Weng Y-H, Yang C-Y, Chiu Y-W. Risk assessment of adverse birth outcomes in relation to maternal age. PLoS One. 2014;9:e114843.CrossRef Weng Y-H, Yang C-Y, Chiu Y-W. Risk assessment of adverse birth outcomes in relation to maternal age. PLoS One. 2014;9:e114843.CrossRef
34.
go back to reference Shrestha R. Maternal mortality in Nepal: addressing the issue. Inquiries J. 2012;4:1–4. Shrestha R. Maternal mortality in Nepal: addressing the issue. Inquiries J. 2012;4:1–4.
35.
go back to reference Viswanath K, Ps R, Chakraborty A, Prasad JH, Minz S, George K. A community based case control study on determinants of perinatal mortality in a tribal population of southern India. Rural Remote Health. 2015;15:3388.PubMed Viswanath K, Ps R, Chakraborty A, Prasad JH, Minz S, George K. A community based case control study on determinants of perinatal mortality in a tribal population of southern India. Rural Remote Health. 2015;15:3388.PubMed
36.
go back to reference Bai J, Wong FW, Bauman A, Mohsin M. Parity and pregnancy outcomes. Am J Obstet Gynecol. 2002;186:274–8.CrossRef Bai J, Wong FW, Bauman A, Mohsin M. Parity and pregnancy outcomes. Am J Obstet Gynecol. 2002;186:274–8.CrossRef
37.
go back to reference Guilbert JJ. The world health report 2002 - reducing risks, promoting healthy life. Educ Health. 2003;16:230.CrossRef Guilbert JJ. The world health report 2002 - reducing risks, promoting healthy life. Educ Health. 2003;16:230.CrossRef
38.
go back to reference Mavalankar DV, Trivedi C, Gray RH. Levels and risk factors for perinatal mortality in Ahmedabad, India. Bull World Health Organ. 1991;69:435.PubMedPubMedCentral Mavalankar DV, Trivedi C, Gray RH. Levels and risk factors for perinatal mortality in Ahmedabad, India. Bull World Health Organ. 1991;69:435.PubMedPubMedCentral
39.
go back to reference Kim K-H, Jahan SA, Kabir E. A review of diseases associated with household air pollution due to the use of biomass fuels. J Hazard Mater. 2011;192:425–31.CrossRef Kim K-H, Jahan SA, Kabir E. A review of diseases associated with household air pollution due to the use of biomass fuels. J Hazard Mater. 2011;192:425–31.CrossRef
40.
go back to reference Bishwakarma P. The situation analysis for dalit women of Nepal. National Seminar on Raising Dalit Participation in governance Centre for Economic and Technical Studies; 2004. Bishwakarma P. The situation analysis for dalit women of Nepal. National Seminar on Raising Dalit Participation in governance Centre for Economic and Technical Studies; 2004.
Metadata
Title
Factors associated with perinatal mortality in Nepal: evidence from Nepal demographic and health survey 2001–2016
Authors
Pramesh Raj Ghimire
Kingsley E. Agho
Andre M. N. Renzaho
Monjura K. Nisha
Michael Dibley
Camille Raynes-Greenow
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Pregnancy and Childbirth / Issue 1/2019
Electronic ISSN: 1471-2393
DOI
https://doi.org/10.1186/s12884-019-2234-6

Other articles of this Issue 1/2019

BMC Pregnancy and Childbirth 1/2019 Go to the issue