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BMC Nephrology
Published in: BMC Nephrology 1/2016

Open Access 01-12-2016 | Research article

Incidence of sudden cardiac death in adults with end-stage renal disease: a systematic review and meta-analysis

Authors: Sharanya Ramesh, Ann Zalucky, Brenda R. Hemmelgarn, Derek J. Roberts, Sofia B. Ahmed, Stephen B. Wilton, Min Jun

Published in: BMC Nephrology | Issue 1/2016

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Abstract

Background

Although sudden cardiac death (SCD) is recognized as a distinct cause of death in patients with end stage renal disease (ESRD), its incidence has not been well summarized.

Methods

We performed a systematic review and meta-analysis of the literature based on a protocol developed a priori. We searched MEDLINE and EMBASE (inception to March 2015) for randomized controlled trials and cohort studies reporting the incidence of SCD in adult patients with ESRD on hemodialysis or peritoneal dialysis. We collected data on number of SCD as well as the definition of SCD for each individual study. A random-effects model was used to summarize the incidence of SCD. We conducted subgroup analyses to explore sources of heterogeneity.

Results

Forty two studies (n = 80,382 patients) were included in the meta-analysis. The incidence of SCD among adults with ESRD ranged from 0.4 to 10.04 deaths per 100 person-years. The definitions and assessment of SCD varied across the included studies. There was evidence of significant heterogeneity (I2 = 98; p < 0.001), which was not explained by subgroup analyses stratified by mean age, proportion of hypertensive or diabetic patients, follow-up time, study size, or type of cohort studied.

Conclusion

Current estimates of the incidence of SCD among adults with ESRD vary widely. There is a need for further studies to more accurately estimate the incidence of SCD in patients with ESRD.
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Metadata
Title
Incidence of sudden cardiac death in adults with end-stage renal disease: a systematic review and meta-analysis
Authors
Sharanya Ramesh
Ann Zalucky
Brenda R. Hemmelgarn
Derek J. Roberts
Sofia B. Ahmed
Stephen B. Wilton
Min Jun
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Nephrology / Issue 1/2016
Electronic ISSN: 1471-2369
DOI
https://doi.org/10.1186/s12882-016-0293-8

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