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BMC Medical Imaging

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Open Access 01-12-2018 | Research article

MPCaD: a multi-scale radiomics-driven framework for automated prostate cancer localization and detection

Authors: Farzad Khalvati, Junjie Zhang, Audrey G. Chung, Mohammad Javad Shafiee, Alexander Wong, Masoom A. Haider

Published in: BMC Medical Imaging | Issue 1/2018

Abstract

Background

Quantitative radiomic features provide a plethora of minable data extracted from multi-parametric magnetic resonance imaging (MP-MRI) which can be used for accurate detection and localization of prostate cancer. While most cancer detection algorithms utilize either voxel-based or region-based feature models, the complexity of prostate tumour phenotype in MP-MRI requires a more sophisticated framework to better leverage available data and exploit a priori knowledge in the field.

Methods

In this paper, we present MPCaD, a novel Multi-scale radiomics-driven framework for Prostate Cancer Detection and localization which leverages radiomic feature models at different scales as well as incorporates a priori knowledge of the field. Tumour candidate localization is first performed using a statistical texture distinctiveness strategy that leverages a voxel-resolution feature model to localize tumour candidate regions. Tumour region classification via a region-resolution feature model is then performed to identify tumour regions. Both voxel-resolution and region-resolution feature models are built upon and extracted from six different MP-MRI modalities. Finally, a conditional random field framework that is driven by voxel-resolution relative ADC features is used to further refine the localization of the tumour regions in the peripheral zone to improve the accuracy of the results.

Results

The proposed framework is evaluated using clinical prostate MP-MRI data from 30 patients, and results demonstrate that the proposed framework exhibits enhanced separability of cancerous and healthy tissue, as well as outperforms individual quantitative radiomics models for prostate cancer detection.

Conclusion

Quantitative radiomic features extracted from MP-MRI of prostate can be utilized to detect and localize prostate cancer.

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Title: MPCaD: a multi-scale radiomics-driven framework for automated prostate cancer localization and detection
Authors: Farzad Khalvati
Junjie Zhang
Audrey G. Chung
Mohammad Javad Shafiee
Alexander Wong
Masoom A. Haider
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: BMC Medical Imaging / Issue 1/2018
Electronic ISSN: 1471-2342
DOI: https://doi.org/10.1186/s12880-018-0258-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

MPCaD: a multi-scale radiomics-driven framework for automated prostate cancer localization and detection

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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