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BMC Infectious Diseases

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Open Access 01-12-2024 | Metronidazole | Case Report

A case of bacteremia caused by Dialister micraerophilus with Enterocloster clostridioformis and Eggerthella lenta in a patient with pyometra

Authors: Hiroki Kitagawa, Kayoko Tadera, Keitaro Omori, Toshihito Nomura, Norifumi Shigemoto, Hiroki Ohge

Published in: BMC Infectious Diseases | Issue 1/2024

Abstract

Background

Infection by Dialister micraerophilus, an obligate anaerobic gram-negative bacillus, has rarely been described, and its clinical characteristics remain unclear.

Case presentation

We report a case of bacteremia caused by D. micraerophilus, Enterocloster clostridioformis, and Eggerthella lenta in a 47-year-old woman, associated with pyometra. D. micraerophilus was identified using 16S rRNA gene sequencing and matrix-assisted laser desorption ionization time-of-flight mass spectrometry. D. micraerophilus was detected by polymerase chain reaction using D. micraerophilus-specific primers and E. clostridioformis and E. lenta was isolated from the drainage pus sample obtained from the pyometra uterus. The patient achieved a cure after abscess drainage and 2-week antibiotic treatment.

Conclusions

To the best of our knowledge, this is the first report of D. micraerophilus bacteremia. D. micraerophilus may be associated with gynecological infections. Clinicians should consider both oral and gynecological sites when searching to identify the focus of D. micraerophilus infection.

Morio F, Jean-Pierre H, Dubreuil L, Jumas-Bilak E, Calvet L, Mercier G, et al. Antimicrobial susceptibilities and clinical sources of Dialister species. Antimicrob Agents Chemother. 2007. https://doi.org/10.1128/AAC.00538-07.CrossRefPubMedPubMedCentral

Pereira RS, Rodrigues VAA, Furtado WT, Gueiros S, Pereira GS, Avila-Campos MJ. Microbial analysis of root canal and periradicular lesion associated to teeth with endodontic failure. Anaerobe. 2017. https://doi.org/10.1016/j.anaerobe.2017.06.016.CrossRefPubMed

Doan N, Contreras A, Flynn J, Jørgen Slots, Chen C. Molecular identification of Dialister pneumosintes in subgingival plaque of humans. J Clin Microbiol. 2000. https://doi.org/10.1128/JCM.38.8.3043-3047.2000.CrossRefPubMedPubMedCentral

Contreras A, Doan N, Chen C, Rusitanonta T, Flynn MJ, Slots J. Importance of Dialister pneumosintes in human periodontitis. Oral Microbiol Immunol. 2000. https://doi.org/10.1034/j.1399-302x.2000.150410.x.CrossRefPubMed

Lee MY, Kim YJ, Gu HJ, Lee HJ. A case of bacteremia caused by Dialister pneumosintes and Slackia exigua in a patient with periapical abscess. Anaerobe. 2016. https://doi.org/10.1016/j.anaerobe.2015.11.006.CrossRefPubMed

Kaiser M, Weis M, Kehr K, Varnholt V, Schroten H, Tenenbaum T. Severe pneumonia and sepsis caused by Dialister pneumosintes in an adolescent. Pathogens. 2021. https://doi.org/10.3390/pathogens10060733.CrossRefPubMedPubMedCentral

Mannan S, Ahmad T, Naeem A, Patel V. A case of Dialister pneumosintes bacteremia-associated neck and mediastinal abscess. Am J Case Rep. 2021. https://doi.org/10.12659/AJCR.930559.CrossRefPubMedPubMedCentral

Kogure M, Suzuki H, Ishiguro S, Ueda A, Nakahara T, Tamai K, et al. Dialister pneumosintes bacteremia caused by dental caries and sinusitis. Intern Med. 2015. https://doi.org/10.2169/internalmedicine.54.2904.CrossRefPubMed

Soeiro C, Quilici IR, Legoff A, Oussalah MB, Morin M, Alauzet C, et al. Hepatic abscess due to Dialister pneumosintes - a case report. Anaerobe. 2019. https://doi.org/10.1016/j.anaerobe.2019.05.006.CrossRefPubMed

10.

Pierre Lepargneur J, Dubreuil L, Levy J. Isolation of Dialister pneumosintes isolated from a bacteremia of vaginal origin. Anaerobe. 2006. https://doi.org/10.1016/j.anaerobe.2006.07.004.CrossRefPubMed

11.

Jumas-Bilak E, Jean-Pierre H, Carlier JP, Teyssier C, Bernard K, Gay B, et al. Dialister micraerophilus sp. nov. and Dialister propionicifaciens sp. nov., isolated from human clinical samples. Int J Syst Evol Microbiol. 2005. https://doi.org/10.1099/ijs.0.63715-0.CrossRefPubMed

12.

Ribeiro AA, Azcarate-Peril A, Cadenas MB, Butz N, Paster BJ, Chen T, et al. The oral bacterial microbiome of occlusal surfaces in children and its association with diet and caries. PLoS ONE. 2017. https://doi.org/10.1371/journal.pone.0180621.CrossRefPubMedPubMedCentral

13.

Dreisbach C, Prescott S, Alhusen JL, Dudley D, Trinchieri G, Siega-Riz AM. Association between microbial composition, diversity, and function of the maternal gastrointestinal microbiome with impaired glucose tolerance on the glucose challenge test. PLoS ONE. 2022. https://doi.org/10.1371/journal.pone.0271261.CrossRefPubMedPubMedCentral

14.

McClelland RS, Lingappa JR, Srinivasan S, Kinuthia J, John-Stewart GC, Jaoko W, et al. Evaluation of the association between the concentrations of key vaginal bacteria and the increased risk of HIV acquisition in African women from five cohorts: a nested case-control study. Lancet Infect Dis. 2018. https://doi.org/10.1016/S1473-3099(18)30058-6.CrossRefPubMedPubMedCentral

15.

Sabo MC, Lehman DA, Wang B, Richardson BA, Srinivasan S, Osborn L, et al. Associations between vaginal bacteria implicated in HIV acquisition risk and proinflammatory cytokines and chemokines. Sex Transm Infect. 2020. https://doi.org/10.1136/sextrans-2018-053949.CrossRefPubMed

16.

Cobo F, Rodríguez-Granger J, Sampedro A, Navarro-Marí JM. Bartholin’s abscess due to Dialister micraerophilus in a woman presenting with repetitive bartholinitis episodes. Méd Mal Infect. 2018. https://doi.org/10.1016/j.medmal.2017.12.008.CrossRefPubMed

17.

Nakaoka Y, Kitagawa H, Kitano H, Koba Y, Hara T, Nagaoka R, et al. Clinical characteristics of Actinotignum schaalii bacteremia in a Japanese tertiary hospital. Anaerobe. 2022. https://doi.org/10.1016/j.anaerobe.2022.102513.CrossRefPubMed

18.

Clinical and Laboratory Standards Institute. M100. Performance standards for antimicrobial susceptibility testing. 33rd ed. Wayne, PA: Clinical and Laboratory Standards Institute; 2023.

19.

Rousée JM, Bermond D, Piemont Y, Tournoud C, Heller R, Kehrli P, et al. Dialister pneumosintes associated with human brain abscesses. J Clin Microbiol. 2002. https://doi.org/10.1128/jcm.40.10.3871-3873.2002.CrossRefPubMedPubMedCentral

20.

Hirai J, Kuruma T, Sakanashi D, Kuge Y, Kishino T, Shibata Y, et al. Lemierre syndrome due to Dialister pneumosintes: a case report. Infect Drug Resist. 2022. https://doi.org/10.2147/IDR.S359074.CrossRefPubMedPubMedCentral

21.

Patel R, Chong DST, Guy AJ, Kennedy M. Dialister pneumosintes and aortic graft infection - a case report. BMC Infect Dis. 2023. https://doi.org/10.1186/s12879-023-08584-3.CrossRefPubMedPubMedCentral

22.

Hagiya H, Ogawa H, Takahashi Y, Kimura K, Hasegawa K, Otsuka F. Actinomyces turicensis bacteremia secondary to pyometra. Intern Med. 2015. https://doi.org/10.2169/internalmedicine.54.4637.CrossRefPubMed

23.

Nagaoka R, Kitagawa H, Koba Y, Tadera K, Hara T, Kashiyama S, et al. Clinical and microbiological characteristics of Eggerthella lenta bacteremia at a Japanese tertiary hospital. J Infect Chemother. 2021. https://doi.org/10.1016/j.jiac.2021.03.019.CrossRefPubMedPubMedCentral

24.

Dumont Y, Bonzon L, Michon AL, Carriere C, Didelot MN, Laurens C, et al. Epidemiology and microbiological features of anaerobic bacteremia in two French University hospitals. Anaerobe. 2020. https://doi.org/10.1016/j.anaerobe.2020.102207.CrossRefPubMed

25.

Watanabe T, Hara Y, Yoshimi Y, Yokoyama-Kokuryo W, Fujita Y, Yokoe M, et al. Application of MALDI-TOF MS to assess clinical characteristics, risk factors, and outcomes associated with anaerobic bloodstream infection: a retrospective observational study. Ann Clin Microbiol Antimicrob. 2021. https://doi.org/10.1186/s12941-021-00449-4.CrossRefPubMedPubMedCentral

26.

Ransom EM, Burnham CD. Routine use of anaerobic blood culture bottles for specimens collected from adults and children enhances microorganism recovery and improves time to positivity. J Clin Microbiol. 2022. https://doi.org/10.1128/jcm.00500-22.CrossRefPubMedPubMedCentral

27.

Minces LR, Shields RK, Sheridan K, Ho KS, Silveira FP. Peptostreptococcus infective endocarditis and bacteremia. Analysis of cases at a tertiary medical center and review of the literature. Anaerobe. 2010. https://doi.org/10.1016/j.anaerobe.2010.03.011.CrossRefPubMed

28.

Mueller-Premru M, Jeverica S, Papst L, Nagy E. Performance of two blood culture systems to detect anaerobic bacteria. Is there any Difference? Anaerobe. 2017. https://doi.org/10.1016/j.anaerobe.2017.03.006.CrossRefPubMed

Title: A case of bacteremia caused by Dialister micraerophilus with Enterocloster clostridioformis and Eggerthella lenta in a patient with pyometra
Authors: Hiroki Kitagawa
Kayoko Tadera
Keitaro Omori
Toshihito Nomura
Norifumi Shigemoto
Hiroki Ohge
Publication date: 01-12-2024
Publisher: BioMed Central
Keyword: Metronidazole
Published in: BMC Infectious Diseases / Issue 1/2024
Electronic ISSN: 1471-2334
DOI: https://doi.org/10.1186/s12879-024-08999-6

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Abstract

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