Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
BMC Gastroenterology
Published in: BMC Gastroenterology 1/2022

Open Access 01-12-2022 | Helicobacter Pylori | Research

Association between dietary antioxidant index and risk of Helicobacter pylori infection among adults: a case–control study

Authors: Zohreh Ebrahimi, Mohsen Masoodi, Zahra Aslani, Sina Naghshi, Masoumeh Khalighi Sikaroudi, Farzad Shidfar

Published in: BMC Gastroenterology | Issue 1/2022

Login to get access

Abstract

Backgrounds and aims

One of the most important risk factors for Helicobacter pylori (H. pylori) infection is nutrition. Balanced diets with high antioxidant properties may have protective effects against the consequences of this infection. In the current study, we aimed to investigate the association between the dietary antioxidant index and the risk of H. pylori infection among adults.

Methods

In a case–control study the dietary intake of patients with H. pylori infection was compared with healthy subjects. The dietary antioxidant index (DAI) was calculated using dietary intakes derived from a validated food frequency questionnaire (FFQ). Demographic information was obtained by a related questionnaire and Physical Activity was measured by International Physical Activity Questionnaire (IPAQ) were used to obtain information. Using logistic regression models, we evaluated the association between the DAI and H. pylori infection risk. The significance level was determined as P < 0.05.

Results

Finally, dietary data of 148 cases and 302 controls (mean age: 38.72 ± 10.61 (were analyzed. The mean of total DAI was significantly higher in controls (7.67) when compared with H. pylori cases (3.57) (P < 0.001). After adjustment for covariates, participants with less than median DAI values had an increased risk of H. pylori onset (adjusted OR 1.08, 95% CI: 1.02–1.12, P < 0.001).

Conclusions

Appropriate intake of nutrient antioxidants may have a role in decreasing the likelihood of H. pylori infection risk.
Literature
1.
Alipour M. Molecular mechanism of Helicobacter pylori-induced gastric cancer. J Gastrointest Cancer. 2021;52(1):23–30.PubMedCrossRef
2.
Hooi JK, Lai WY, Ng WK, Suen MM, Underwood FE, Tanyingoh D, Malfertheiner P, Graham DY, Wong VW, Wu JC. Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis. Gastroenterology. 2017;153(2):420–9.CrossRefPubMed
3.
Mezmale L, Coelho LG, Bordin D, Leja M. Epidemiology of Helicobacter pylori. Helicobacter. 2020;25: e12734.PubMedCrossRef
4.
Bardazzi F, Magnano M, Fiorini G, Vaira D, Odorici G, Bertusi G, Patrizi A, Helicobacter Pylori infection in psoriatic patients during biological therapy. Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Societa Italiana di Dermatologia e Sifilografia 2020.
5.
6.
Öztekin M, Yılmaz B, Ağagündüz D, Capasso R. Overview of Helicobacter pylori Infection: clinical features, treatment, and nutritional aspects. Diseases. 2021;9(4):66.PubMedPubMedCentralCrossRef
7.
Shu L, Zheng P-F, Zhang X-Y, Feng Y-L: Dietary patterns and Helicobacter pylori infection in a group of Chinese adults ages between 45 and 59 years old: an observational study. Medicine 2019;98(2):1–8.
8.
Xia Y, Meng G, Zhang Q, Liu L, Wu H, Shi H, Bao X, Su Q, Gu Y, Fang L. Dietary patterns are associated with Helicobacter pylori infection in Chinese adults: a cross-sectional study. Sci Rep. 2016;6(1):1–8.
9.
Johansen JS, Harris AK, Rychly DJ, Ergul A. Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice. Cardiovasc Diabetol. 2005;4(1):1–11.CrossRef
10.
Yang-Ou YB, Hu Y, Zhu Y, Lu NH. The effect of antioxidants on Helicobacter pylori eradication: a systematic review with meta-analysis. Helicobacter. 2018;23(6): e12535.PubMedCrossRef
11.
Salgueiro J, Zubillaga M, Goldman C, Barrado A, Martinez Sarrasague M, Leonardi N, Boccio J. is there a link between micronutrient malnutrition and Helicobacter pylori infection? Aliment Pharmacol Ther. 2004;20(10):1029–34.PubMedCrossRef
12.
Solnick JV, Franceschi F, Roccarina D, Gasbarrini A. Extragastric manifestations of Helicobacter pylori infection–other Helicobacter species. Helicobacter. 2006;11:46–51.PubMedCrossRef
13.
Capurso G, Ricci R, Panzuto F, Baccini F, Passi S, Di Giulio E, Fave GD, Annibale B. Intragastric ascorbic but not uric acid is depleted in relation with the increased pH in patients with atrophic body gastritis and H. pylori gastritis. Helicobacter. 2003;8(4):300–6.PubMedCrossRef
14.
Vitale G, Barbaro F, Ianiro G, Cesario V, Gasbarrini G, Franceschi F, Gasbarrini A. Nutritional aspects of Helicobacter pylori infection. Minerva Gastroenterol Dietol. 2011;57(4):369–77.PubMed
15.
Wang X, Willén R, Wadström T. Astaxanthin-rich algal meal and vitamin C inhibit Helicobacter pylori infection in BALB/cA mice. Antimicrob Agents Chemother. 2000;44(9):2452–7.PubMedPubMedCentralCrossRef
16.
Sezikli M, Çetinkaya ZA, Güzelbulut F, Çimen B, Özcan Ö, Özkara S, Yeşil A, Gümrükçü G, İpçioğlu OM, Sezikli H. Effects of alpha tocopherol and ascorbic acid on Helicobacter pylori colonization and the severity of gastric inflammation. Helicobacter. 2012;17(2):127–32.PubMedCrossRef
17.
Rokkas T, Papatheodorou G, Karameris A, Mavrogeorgis A, Kalogeropoulos N, Giannikos N. Helicobacter pylori infection and gastric juice vitamin C levels. Dig Dis Sci. 1995;40(3):615–21.PubMedCrossRef
18.
Woodward M, Tunstall-Pedoe H, McColl K. Helicobacter pylori infection reduces systemic availability of dietary vitamin C. Eur J Gastroenterol Hepatol. 2001;13(3):233–7.PubMedCrossRef
19.
Rokkas T, Liatsos C, Petridou E, Papatheodorou G, Karameris A, Ladas S, Raptis S. Relationship of Helicobacter pylori CagA (+) status to gastric juice vitamin C levels. Eur J Clin Invest. 1999;29(1):56–62.PubMedCrossRef
20.
Sanderson MJ, White K, Drake IM, Schorah CJ. Vitamin E and carotenoids in gastric biopsies: the relation to plasma concentrations in patients with and without Helicobacter pylori gastritis. Am J Clin Nutr. 1997;65(1):101–6.PubMedCrossRef
21.
Sugimoto N, Yoshida N, Nakamura Y, Ichikawa H, Naito Y, Okanoue T, Yoshikawa T. Influence of vitamin E on gastric mucosal injury induced by Helicobacter pylori infection. BioFactors. 2006;28(1):9–19.PubMedCrossRef
22.
Fung TT, Hu FB, Pereira MA, Liu S, Stampfer MJ, Colditz GA, Willett WC. Whole-grain intake and the risk of type 2 diabetes: a prospective study in men. Am J Clin Nutr. 2002;76(3):535–40.PubMedCrossRef
23.
Ahmad S, Harris T, Limb E, Kerry S, Victor C, Ekelund U, Iliffe S, Whincup P, Beighton C, Ussher M. Evaluation of reliability and validity of the General Practice Physical Activity Questionnaire (GPPAQ) in 60–74 year old primary care patients. BMC Fam Pract. 2015;16(1):1–9.CrossRef
24.
Esfahani FH, Asghari G, Mirmiran P, Azizi F. Reproducibility and relative validity of food group intake in a food frequency questionnaire developed for the Tehran Lipid and Glucose Study. J Epidemiol. 2010;20(2):150–8.PubMedCrossRef
25.
LuuHung N, Are dietary antioxidant intake indices correlated to oxidative stress and inflammatory marker levels?. In.: Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA; 2015.
26.
Abdollahpour I, Nedjat S, Salimi Y, Mansournia MA, Vahid F, Weinstock-Guttman B. The role of dietary antioxidant index and index of nutritional quality in MS onset: finding from an Iranian population-based incident case–control study. Nutr Neurosci. 2020;25(2):1–8.
27.
Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem. 1996;239(1):70–6.PubMedCrossRef
28.
29.
Vahid F, Rahmani D, Davoodi SH. Validation of Dietary Antioxidant Index (DAI) and investigating the relationship between DAI and the odds of gastric cancer. Nutr Metab. 2020;17(1):102.CrossRef
30.
31.
Vahid F, Rahmani D, Hekmatdoost A. The association between dietary antioxidant index (DAI) and nonalcoholic fatty liver disease (NAFLD) onset; new findings from an incident case-control study. Clinical nutrition ESPEN. 2021;41:360–4.PubMedCrossRef
32.
Vahid F, Rahmani D, Davoodi SH. The correlation between serum inflammatory, antioxidant, glucose handling biomarkers, and Dietary Antioxidant Index (DAI) and the role of DAI in obesity/overweight causation: population-based case-control study. Int J Obes. 2021;45(12):2591–9.CrossRef
33.
34.
Jarosz M, Rychlik E, Siuba M, Respondek W, Ryzko-Skiba M, Sajór I, Gugała S, Błazejczyk T, Ciok J. Dietary and socio-economic factors in relation to Helicobacter pylori re-infection. World J Gastroenterol. 2009;15(9):1119–25.PubMedPubMedCentralCrossRef
35.
Annibale B, Capurso G, Lahner E, Passi S, Ricci R, Maggio F, Delle Fave G. Concomitant alterations in intragastric pH and ascorbic acid concentration in patients with Helicobacter pylori gastritis and associated iron deficiency anaemia. Gut. 2003;52(4):496–501.PubMedPubMedCentralCrossRef
36.
Kashimura H, Suzuki K, Hassan M, Ikezawa K, Sawahata T, Watanabe T, Nakahara A, Mutoh H, Tanaka N. Polaprezinc, a mucosal protective agent, in combination with lansoprazole, amoxycillin and clarithromycin increases the cure rate of Helicobacter pylori infection. Aliment Pharmacol Ther. 1999;13(4):483–7.PubMedCrossRef
37.
Sempértegui F, Diaz M, Mejia R, Rodríguez-Mora OG, Rentería E, Guarderas C, Estrella B, Recalde R, Hamer DH, Reeves PG. Low Concentrations of zinc in gastric Mucosa are associated with increased severity of helicobacter pylori-induced inflammation. Helicobacter. 2007;12(1):43–8.PubMedCrossRef
38.
Zhang HM, Wakisaka N, Maeda O, Yamamoto T. Vitamin C inhibits the growth of a bacterial risk factor for gastric carcinoma: Helicobacter pylori. Cancer: Interdisc Int J Am Cancer Soc. 1997;80(10):1897–903.CrossRef
39.
Sjunnesson H, Sturegård E, Willén R, Wadström T. High intake of selenium, -carotene, and vitamins A, C, and E reduces growth of Helicobacter pylori in the Guinea Pig. Comp Med. 2001;51(5):418–23.PubMed
40.
Ishihara R, Iishi H, Sakai N, Yano H, Uedo N, Narahara H, Iseki K, Mikuni T, Ishiguro S, Tatsuta M. Polaprezinc attenuates Helicobacter pylori-associated gastritis in Mongolian gerbils. Helicobacter. 2002;7(6):384–9.PubMedCrossRef
41.
Suzuki H, Mori M, Seto K, Miyazawa M, Kai A, Suematsu M, Yoneta T, Miura S, Ishii H. Polaprezinc attenuates the Helicobacter pylori-induced gastric mucosal leucocyte activation in Mongolian gerbils—a study using intravital videomicroscopy. Aliment Pharmacol Ther. 2001;15(5):715–25.PubMedCrossRef
42.
Li G, Li L, Yu C, Chen L. Effect of vitamins C and E supplementation on Helicobacter pylori eradication: a meta-analysis. Br J Nutr. 2011;106(11):1632–7.PubMedCrossRef
43.
Ochoa EYC, Moreno COQ, Fandiño YRM, Fonseca SCS, Motta HFC, Guerra SAG. Assessment of the use of vitamin C and E supplements concomitantly to antibiotic treatment against Helicobacter pylori: a systematic review and meta-analysis. Med Clínica (English Edition). 2018;151(2):45–52.CrossRef
44.
45.
Woodside JV, McCall D, McGartland C, Young IS. Micronutrients: dietary intake v. supplement use. Proc Nutr Soc. 2005;64(4):543–53.PubMedCrossRef
46.
Pal J, Sanal MG, Gopal GJ. Vitamin-C as anti-Helicobacter pylori agent: more prophylactic than curative-Critical review. Indian J Pharmacol. 2011;43(6):624.PubMedPubMedCentral
47.
Nilius M, Bode G, Lehnhardt G, Malfertheiner P. In vitro inhibition of Helicobacter pylori urease: biochemical and ultrastructural analysis. Eur J Clin Invest. 1991;21(5):551–7.PubMedCrossRef
48.
Jarosz M, Dzieniszewski J, Dabrowska-Ufniarz E, Wartanowicz M, Ziemlanski S, Reed P. Effects of high dose vitamin C treatment on Helicobacter pylori infection and total vitamin C concentration in gastric juice. Eur J Cancer Prev. 1998;7(6):449–54.CrossRef
49.
Phull PS, Green CJ, Jacyna MR. A radical view of the stomach: the role of oxygen-derived free radicals and anti-oxidants in gastroduodenal disease. Eur J Gastroenterol Hepatol. 1995;7(3):265–74.PubMed
Metadata
Title
Association between dietary antioxidant index and risk of Helicobacter pylori infection among adults: a case–control study
Authors
Zohreh Ebrahimi
Mohsen Masoodi
Zahra Aslani
Sina Naghshi
Masoumeh Khalighi Sikaroudi
Farzad Shidfar
Publication date
01-12-2022
Publisher
BioMed Central
Published in
BMC Gastroenterology / Issue 1/2022
Electronic ISSN: 1471-230X
DOI
https://doi.org/10.1186/s12876-022-02488-3

Other articles of this Issue 1/2022

BMC Gastroenterology 1/2022 Go to the issue

Case report

Cholangiocarcinoma presenting as dysphagia and misdiagnosed as gastritis: a case report

Research article

Experimental non-alcoholic fatty liver disease causes regional liver functional deficits as measured by the capacity for galactose metabolism while whole liver function is preserved

Research

Prevalence and factors associated with fatigue in patients with ulcerative colitis in China: a cross-sectional study

Case report

Are we forgetting to carry out serum protein electrophoresis as part of diagnosis workup?

Case report

Recurrent spontaneous pneumoperitoneum secondary to intestinal dilatation caused by allied disorders of Hirschsprung’s disease: a case report

Research

Pharmacodynamic mechanisms behind a refractory state in inflammatory bowel disease
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
Image Credits