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Published in: BMC Primary Care 1/2019

Open Access 01-12-2019 | Care | Research article

Identifying heterogeneous health profiles of primary care utilizers and their differential healthcare utilization and mortality – a retrospective cohort study

Authors: Shi Yan, Benjamin Jun Jie Seng, Yu Heng Kwan, Chuen Seng Tan, Joanne Hui Min Quah, Julian Thumboo, Lian Leng Low

Published in: BMC Primary Care | Issue 1/2019

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Abstract

Background

Heterogeneity of population health needs and the resultant difficulty in health care resources planning are challenges faced by primary care systems globally. To address this challenge in population health management, it is critical to have a better understanding of primary care utilizers’ heterogeneous health profiles. We aimed to segment a population of primary care utilizers into classes with unique disease patterns, and to report the 1 year follow up healthcare utilizations and all-cause mortality across the classes.

Methods

Using de-identified administrative data, we included all adult Singapore citizens or permanent residents who utilized Singapore Health Services (SingHealth) primary care services in 2012. Latent class analysis was used to identify patient subgroups having unique disease patterns in the population. The models were assessed by Bayesian Information Criterion and clinical interpretability. We compared healthcare utilizations in 2013 and one-year all-cause mortality across classes and performed regression analysis to assess predictive ability of class membership on healthcare utilizations and mortality.

Results

We included 100,747 patients in total. The best model (k = 6) revealed the following classes of patients: Class 1 “Relatively healthy” (n = 58,213), Class 2 “Stable metabolic disease” (n = 26,309), Class 3 “Metabolic disease with vascular complications” (n = 2964), Class 4 “High respiratory disease burden” (n = 1104), Class 5 “High metabolic disease without complication” (n = 11,122), and Class 6 “Metabolic disease with multi-organ complication” (n = 1035). The six derived classes had different disease patterns in 2012 and 1 year follow up healthcare utilizations and mortality in 2013. “Metabolic disease with multiple organ complications” class had the highest healthcare utilization (e.g. incidence rate ratio = 19.68 for hospital admissions) and highest one-year all-cause mortality (hazard ratio = 27.97).

Conclusions

Primary care utilizers are heterogeneous and can be segmented by latent class analysis into classes with unique disease patterns, healthcare utilizations and all-cause mortality. This information is critical to population level health resource planning and population health policy formulation.
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Literature
5.
go back to reference Shi L, Macinko J, Starfield B, Politzer R, Wulu J, Xu J. Primary care, social inequalities, and all-cause, heart disease, and cancer mortality in US counties, 1990. Am J Public Health. 2005;95:674–80.CrossRef Shi L, Macinko J, Starfield B, Politzer R, Wulu J, Xu J. Primary care, social inequalities, and all-cause, heart disease, and cancer mortality in US counties, 1990. Am J Public Health. 2005;95:674–80.CrossRef
6.
go back to reference Transforming the primary care landscape: Engaging the GP community and our stakeholders in the journey | Ministry of Health. https://www.moh.gov.sg/content/moh_web/home/pressRoom/pressRoomItemRelease/2011/transforming_theprimarycarelandscapeengagingthegpcommunityandour.html. Accessed 7 June 2018. Transforming the primary care landscape: Engaging the GP community and our stakeholders in the journey | Ministry of Health. https://​www.​moh.​gov.​sg/​content/​moh_​web/​home/​pressRoom/​pressRoomItemRel​ease/​2011/​transforming_​theprimarycarela​ndscapeengagingt​hegpcommunityand​our.​html.​ Accessed 7 June 2018.
8.
go back to reference Rijckmans M, Garretsen H, Van De Goor I, Bongers I. Demand-oriented and demand-driven health care: the development of a typology. Scand J Caring Sci. 2007;21:406–16.CrossRef Rijckmans M, Garretsen H, Van De Goor I, Bongers I. Demand-oriented and demand-driven health care: the development of a typology. Scand J Caring Sci. 2007;21:406–16.CrossRef
12.
go back to reference Low LL, Kwan YH, Liu N, Jing X, Low ECT, Thumboo J. Evaluation of a practical expert defined approach to patient population segmentation: a case study in Singapore. BMC Health Serv Res. 2017;17:771. Low LL, Kwan YH, Liu N, Jing X, Low ECT, Thumboo J. Evaluation of a practical expert defined approach to patient population segmentation: a case study in Singapore. BMC Health Serv Res. 2017;17:771.
15.
go back to reference Vuik SI, Mayer EK, Darzi A. Patient segmentation analysis offers significant benefits for integrated care and support. Health Aff. 2016;35:769–75.CrossRef Vuik SI, Mayer EK, Darzi A. Patient segmentation analysis offers significant benefits for integrated care and support. Health Aff. 2016;35:769–75.CrossRef
16.
go back to reference Eissens van der Laan MR, van Offenbeek MAG, Broekhuis H, Slaets JPJ. A person-centred segmentation study in elderly care: towards efficient demand-driven care. Soc Sci Med. 2014;113:68–76.CrossRef Eissens van der Laan MR, van Offenbeek MAG, Broekhuis H, Slaets JPJ. A person-centred segmentation study in elderly care: towards efficient demand-driven care. Soc Sci Med. 2014;113:68–76.CrossRef
17.
go back to reference Ledere BS, Bégin C, Cadieux É, Goulet L, Allaire JF, Meloche J, et al. A classification and regression tree for predicting recurrent falling among community-dwelling seniors using home-care services. Can J Public Heal. 2009;100:263–7. Ledere BS, Bégin C, Cadieux É, Goulet L, Allaire JF, Meloche J, et al. A classification and regression tree for predicting recurrent falling among community-dwelling seniors using home-care services. Can J Public Heal. 2009;100:263–7.
18.
go back to reference Bird M, Datta GD, van Hulst A, Cloutier MS, Henderson M, Barnett TA. A park typology in the QUALITY cohort: implications for physical activity and truncal fat among youth at risk of obesity. Prev Med (Baltim). 2016;90:133–8.CrossRef Bird M, Datta GD, van Hulst A, Cloutier MS, Henderson M, Barnett TA. A park typology in the QUALITY cohort: implications for physical activity and truncal fat among youth at risk of obesity. Prev Med (Baltim). 2016;90:133–8.CrossRef
19.
go back to reference Dodd LJ, Al-Nakeeb Y, Nevill A, Forshaw MJ. Lifestyle risk factors of students: a cluster analytical approach. Prev Med (Baltim). 2010;51:73–7.CrossRef Dodd LJ, Al-Nakeeb Y, Nevill A, Forshaw MJ. Lifestyle risk factors of students: a cluster analytical approach. Prev Med (Baltim). 2010;51:73–7.CrossRef
20.
go back to reference Holland ML, Xia Y, Kitzman HJ, Dozier AM, Olds DL. Patterns of visit attendance in the nurse-family partnership program. Am J Public Health. 2014;104:e58–65.CrossRef Holland ML, Xia Y, Kitzman HJ, Dozier AM, Olds DL. Patterns of visit attendance in the nurse-family partnership program. Am J Public Health. 2014;104:e58–65.CrossRef
23.
go back to reference Quan H, Li B, Couris CM, Fushimi K, Graham P, Hider P, et al. Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol. 2011;173:676–82.CrossRef Quan H, Li B, Couris CM, Fushimi K, Graham P, Hider P, et al. Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol. 2011;173:676–82.CrossRef
24.
go back to reference Quan H, Sundararajan V, Halfon P, Fong A, Burnand B, Luthi JC, et al. Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med Care. 2005;43:1130–9.CrossRef Quan H, Sundararajan V, Halfon P, Fong A, Burnand B, Luthi JC, et al. Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med Care. 2005;43:1130–9.CrossRef
26.
go back to reference Sharabiani MTA, Aylin P, Bottle A. Systematic review of comorbidity indices for administrative data. Med Care. 2012;2012:1109–18.CrossRef Sharabiani MTA, Aylin P, Bottle A. Systematic review of comorbidity indices for administrative data. Med Care. 2012;2012:1109–18.CrossRef
27.
go back to reference Dominick KL, Dudley TK, Coffman CJ, Bosworth HB. Comparison of three comorbidity measures for predicting health service use in patients with osteoarthritis. Arthritis Care Res. 2005;53(5):666–72.CrossRef Dominick KL, Dudley TK, Coffman CJ, Bosworth HB. Comparison of three comorbidity measures for predicting health service use in patients with osteoarthritis. Arthritis Care Res. 2005;53(5):666–72.CrossRef
28.
go back to reference Muthén LK, Muthén BO. Mplus User’s Guide. 8th ed; 2017. Muthén LK, Muthén BO. Mplus User’s Guide. 8th ed; 2017.
29.
go back to reference Liu LF, Tian WH, Yao HP. The heterogeneous health latent classes of elderly people and their socio-demographic characteristics in Taiwan. Arch Gerontol Geriatr. 2014;58:205–13.CrossRef Liu LF, Tian WH, Yao HP. The heterogeneous health latent classes of elderly people and their socio-demographic characteristics in Taiwan. Arch Gerontol Geriatr. 2014;58:205–13.CrossRef
31.
go back to reference Muthén L, Muthén B. Mplus Version 7 user’s guide. Los Angeles: CA Muthén Muthén; 2012. Muthén L, Muthén B. Mplus Version 7 user’s guide. Los Angeles: CA Muthén Muthén; 2012.
34.
go back to reference Vermunt JK, Magidson J. Factor analysis with categorical indicators: a comparison between: traditional and latent class approaches. In: New developments in categorical data analysis for the social and behavioral sciences; 2004. p. 33–51. Vermunt JK, Magidson J. Factor analysis with categorical indicators: a comparison between: traditional and latent class approaches. In: New developments in categorical data analysis for the social and behavioral sciences; 2004. p. 33–51.
35.
go back to reference Brinkley-Rubinstein L, Craven K. A latent class analysis of stigmatizing attitudes and knowledge of HIV risk among youth in South Africa. PLoS One. 2014;9:e89915.CrossRef Brinkley-Rubinstein L, Craven K. A latent class analysis of stigmatizing attitudes and knowledge of HIV risk among youth in South Africa. PLoS One. 2014;9:e89915.CrossRef
36.
go back to reference Raftery AE. Bayesian model selection in social research. Sociol Methodol. 1995;25:111–63.CrossRef Raftery AE. Bayesian model selection in social research. Sociol Methodol. 1995;25:111–63.CrossRef
37.
go back to reference Hayden JA, Côté P, Steenstra IA, Bombardier C. Identifying phases of investigation helps planning, appraising, and applying the results of explanatory prognosis studies. J Clin Epidemiol. 2008;61(6):552–60.CrossRef Hayden JA, Côté P, Steenstra IA, Bombardier C. Identifying phases of investigation helps planning, appraising, and applying the results of explanatory prognosis studies. J Clin Epidemiol. 2008;61(6):552–60.CrossRef
38.
go back to reference Kent P, Stochkendahl MJ, Christensen HW, Kongsted A. Could the clinical interpretability of subgroups detected using clustering methods be improved by using a novel two-stage approach? Chiropr Man Ther. 2015;23(1):20. Kent P, Stochkendahl MJ, Christensen HW, Kongsted A. Could the clinical interpretability of subgroups detected using clustering methods be improved by using a novel two-stage approach? Chiropr Man Ther. 2015;23(1):20.
39.
go back to reference Chung RJ, Touloumtzis C, Gooding H. Staying young at heart: cardiovascular disease prevention in adolescents and young adults. Curr Treat Options Cardiovasc Med. 2015;17(12):61. Chung RJ, Touloumtzis C, Gooding H. Staying young at heart: cardiovascular disease prevention in adolescents and young adults. Curr Treat Options Cardiovasc Med. 2015;17(12):61.
41.
go back to reference Bartholomew Eldrigde LK, Markham CM, Ruiter RAC, Fernàndez ME, Kok G, Parcel GS. Planning health promotion programs: an intervention mapping approach; 2011. Bartholomew Eldrigde LK, Markham CM, Ruiter RAC, Fernàndez ME, Kok G, Parcel GS. Planning health promotion programs: an intervention mapping approach; 2011.
42.
go back to reference Lafortune L, Béland F, Bergman H, Ankri J. Health state profiles and service utilization in community-living elderly. Med Care. 2009;47:286–94.CrossRef Lafortune L, Béland F, Bergman H, Ankri J. Health state profiles and service utilization in community-living elderly. Med Care. 2009;47:286–94.CrossRef
43.
go back to reference Simon GE, Goldberg DP, Von Korff M, Üstün TB. Understanding cross-national differences in depression prevalence. Psychol Med. 2002;32(4):585–94.CrossRef Simon GE, Goldberg DP, Von Korff M, Üstün TB. Understanding cross-national differences in depression prevalence. Psychol Med. 2002;32(4):585–94.CrossRef
44.
go back to reference Littlewood R. From categories to contexts: a decade of the “new cross-cultural psychiatry.”. Br J Psychiatry. 1990;156(3):308–27.CrossRef Littlewood R. From categories to contexts: a decade of the “new cross-cultural psychiatry.”. Br J Psychiatry. 1990;156(3):308–27.CrossRef
45.
go back to reference Lo Siou G, Yasui Y, Csizmadi I, McGregor SE, Robson PJ. Exploring statistical approaches to diminish subjectivity of cluster analysis to derive dietary patterns. Am J Epidemiol. 2011;173:956–67.CrossRef Lo Siou G, Yasui Y, Csizmadi I, McGregor SE, Robson PJ. Exploring statistical approaches to diminish subjectivity of cluster analysis to derive dietary patterns. Am J Epidemiol. 2011;173:956–67.CrossRef
49.
go back to reference Bailey RL, Gutschall MD, Mitchell DC, Miller CK, Lawrence FR, Smiciklas-Wright H. Comparative strategies for using cluster analysis to assess dietary patterns. J Am Diet Assoc. 2006;106:1194–200.CrossRef Bailey RL, Gutschall MD, Mitchell DC, Miller CK, Lawrence FR, Smiciklas-Wright H. Comparative strategies for using cluster analysis to assess dietary patterns. J Am Diet Assoc. 2006;106:1194–200.CrossRef
50.
go back to reference Erlich Z, Gelbard R, Spiegler I. Evaluating a positive attribute clustering model for data mining. J Comput Inf Syst. 2003;43:100–8. Erlich Z, Gelbard R, Spiegler I. Evaluating a positive attribute clustering model for data mining. J Comput Inf Syst. 2003;43:100–8.
51.
go back to reference Jadczaková V. Review of segmentation process in consumer markets. Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis. 2013;61:1215–24.CrossRef Jadczaková V. Review of segmentation process in consumer markets. Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis. 2013;61:1215–24.CrossRef
Metadata
Title
Identifying heterogeneous health profiles of primary care utilizers and their differential healthcare utilization and mortality – a retrospective cohort study
Authors
Shi Yan
Benjamin Jun Jie Seng
Yu Heng Kwan
Chuen Seng Tan
Joanne Hui Min Quah
Julian Thumboo
Lian Leng Low
Publication date
01-12-2019
Publisher
BioMed Central
Keyword
Care
Published in
BMC Primary Care / Issue 1/2019
Electronic ISSN: 2731-4553
DOI
https://doi.org/10.1186/s12875-019-0939-2

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