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Open Access 01-12-2023 | Postoperative Nausea and Vomiting | Research

Effects of xenon anesthesia on postoperative neurocognitive disorders: a systematic review and meta-analysis

Authors: Yu-Shen Yang, Shan-Hu Wu, Wei-Can Chen, Meng-Qin Pei, Yi-Bin Liu, Chu-Yun Liu, Shu Lin, He-Fan He

Published in: BMC Anesthesiology | Issue 1/2023

Abstract

The latest clinical trials have reported conflicting outcomes regarding the effectiveness of xenon anesthesia in preventing postoperative neurocognitive dysfunction; thus, this study assessed the existing evidence. We searched the PubMed, Embase, Cochrane Library, and Web of Science databases from inception to April 9, 2023, for randomized controlled trials of xenon anesthesia in postoperative patients. We included English-language randomized controlled studies of adult patients undergoing surgery with xenon anesthesia that compared its effects to those of other anesthetics. Duplicate studies, pediatric studies, and ongoing clinical trials were excluded. Nine studies with 754 participants were identified. A forest plot revealed that the incidence of postoperative neurocognitive dysfunction did not differ between the xenon anesthesia and control groups (P = 0.43). Additionally, xenon anesthesia significantly shortened the emergence time for time to opening eyes (P < 0.001), time to extubation (P < 0.001), time to react on demand (P = 0.01), and time to time and spatial orientation (P = 0.04). However, the Aldrete score significantly increased with xenon anesthesia (P = 0.005). Postoperative complications did not differ between the anesthesia groups. Egger’s test for bias showed no small-study effect, and a trim-and-fill analysis showed no apparent publication bias. In conclusion, xenon anesthesia probably did not affect the occurrence of postoperative neurocognitive dysfunction. However, xenon anesthesia may effectively shorten the emergence time of certain parameters without adverse effects.

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Title: Effects of xenon anesthesia on postoperative neurocognitive disorders: a systematic review and meta-analysis
Authors: Yu-Shen Yang
Shan-Hu Wu
Wei-Can Chen
Meng-Qin Pei
Yi-Bin Liu
Chu-Yun Liu
Shu Lin
He-Fan He
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Postoperative Nausea and Vomiting
Sevoflurane
Published in: BMC Anesthesiology / Issue 1/2023
Electronic ISSN: 1471-2253
DOI: https://doi.org/10.1186/s12871-023-02316-5

2024 ASCO Annual Meeting

Springer Medicine

Effects of xenon anesthesia on postoperative neurocognitive disorders: a systematic review and meta-analysis

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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