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BMC Anesthesiology

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Open Access 01-12-2023 | Lung Cancer | Research

Effect of one-lung ventilation on the correlation between left and right cerebral saturation

Authors: Cai-Juan Zhang, Jia-Hui Ma, Fan Jin, Xiu-Hua Li, Hui-Qun Jia, Dong-Liang Mu

Published in: BMC Anesthesiology | Issue 1/2023

Abstract

Background

To investigate if the correlation between left and right cerebral tissue oxygen saturation (SctO₂) was affected by one-lung ventilation (OLV) in patients undergoing lung cancer surgery.

Methods

Patients who underwent surgery for lung cancer were enrolled. Left and right SctO₂ were collected during anesthesia. The primary outcome was the correlation between left and right SctO₂ at 30 min after OLV which was analysed by Pearson correlation and linear regression model. Secondary outcomes included the trend of left–right SctO₂ change over the first 30 min after OLV, correlation of left–right SctO₂ during OLV for each patient; maximal difference between left–right SctO₂ and its relationship with postoperative delirium.

Results

Left–right SctO₂ was moderately correlated at baseline (r = 0.690, P < 0.001) and poorly correlated at 30 min after OLV (r = 0.383, P < 0.001) in the Pearson correlation analysis. Linear regression analysis showed a poor correlation between left and right SctO₂ at 30 min after OLV (r = 0.323, P < 0.001) after adjusting for confounders. The linear mixed model showed a change in left–right SctO₂ over the first 30 min after OLV that was statistically significant (coefficient, -0.042; 95% CI, -0.070–-0.014; P = 0.004). For the left–right SctO₂ correlation during OLV in each patient, 62.9% (78/124) patients showed a strong correlation, 19.4% (24/124) a medium correlation, and the rest a poor correlation. The maximal difference between the left and right SctO₂ was 13.5 (9.0, 20.0). Multivariate analysis showed that it was not associated with delirium (odds ratio [OR], 1.023; 95% CI, 0.963–1.087; P = 0.463).

Conclusions

The correlation between left and right SctO₂ was affected by one-lung ventilation in patients undergoing lung cancer surgery. This result indicates the requirement of bilateral SctO₂ monitoring to reflect brain oxygenation.

Trial registration

This study was a secondary analysis of a cohort study approved by the Clinical Research Review Board of Peking University First Hospital (#2017–1378) and was registered in the Chinese Clinical Trial Registry on 10/09/2017 (http://www.chictr.org.cn, ChiCTR-ROC-17012627).

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Title: Effect of one-lung ventilation on the correlation between left and right cerebral saturation
Authors: Cai-Juan Zhang
Jia-Hui Ma
Fan Jin
Xiu-Hua Li
Hui-Qun Jia
Dong-Liang Mu
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Lung Cancer
Lung Cancer
Lung Cancer
Published in: BMC Anesthesiology / Issue 1/2023
Electronic ISSN: 1471-2253
DOI: https://doi.org/10.1186/s12871-023-02001-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effect of one-lung ventilation on the correlation between left and right cerebral saturation

Abstract

Background

Methods

Results

Conclusions

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Trial registration

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