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Environmental Health and Preventive Medicine

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Open Access 01-12-2019 | Research article

Associations between metal concentrations in whole blood and placenta previa and placenta accreta: the Japan Environment and Children’s Study (JECS)

Authors: Mayumi Tsuji, Eiji Shibata, David J. Askew, Seiichi Morokuma, Yukiyo Aiko, Ayako Senju, Shunsuke Araki, Masafumi Sanefuji, Yasuhiro Ishihara, Rie Tanaka, Koichi Kusuhara, Toshihiro Kawamoto, Japan Environment and Children’s Study Group

Published in: Environmental Health and Preventive Medicine | Issue 1/2019

Abstract

Background

Placenta previa and placenta accreta associate with high morbidity and mortality for both mothers and fetus. Metal exposure may have relationships with placenta previa and placenta accreta. This study analyzed the associations between maternal metal (cadmium [Cd], lead [Pb], mercury [Hg], selenium [Se], and manganese [Mn]) concentrations and placenta previa and placenta accreta.

Methods

We recruited 17,414 women with singleton pregnancies. Data from a self-administered questionnaire regarding the first trimester and medical records after delivery were analyzed. Maternal blood samples were collected to measure metal concentrations. The subjects were classified into four quartiles (Q1, Q2, Q3, and Q4) according to metal concentrations.

Results

The odds ratio for placenta previa was significantly higher among subjects with Q4 Cd than those with Q1 Cd. The odds ratio for placenta previa was significantly higher for subjects with Q2 Pb than those with Q1 Pb.

Conclusion

Participants with placenta previa had higher Cd concentrations. However, this study was cross-sectional and lacked important information related to Cd concentration, such as detailed smoking habits and sources of Cd intake. In addition, the subjects in this study comprised ordinary pregnant Japanese women, and it was impossible to observe the relationship between a wide range of Cd exposure and placenta previa. Therefore, epidemiological and experimental studies are warranted to verify the relationship between Cd exposure and pregnancy abnormalities.

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Title: Associations between metal concentrations in whole blood and placenta previa and placenta accreta: the Japan Environment and Children’s Study (JECS)
Authors: Mayumi Tsuji
Eiji Shibata
David J. Askew
Seiichi Morokuma
Yukiyo Aiko
Ayako Senju
Shunsuke Araki
Masafumi Sanefuji
Yasuhiro Ishihara
Rie Tanaka
Koichi Kusuhara
Toshihiro Kawamoto
Japan Environment and Children’s Study Group
Publication date: 01-12-2019
Publisher: BioMed Central
Published in: Environmental Health and Preventive Medicine / Issue 1/2019
Print ISSN: 1342-078X
Electronic ISSN: 1347-4715
DOI: https://doi.org/10.1186/s12199-019-0795-7

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Associations between metal concentrations in whole blood and placenta previa and placenta accreta: the Japan Environment and Children’s Study (JECS)

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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