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Environmental Health and Preventive Medicine

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Open Access 01-12-2018 | Study Protocol

The Murakami Cohort Study of vitamin D for the prevention of musculoskeletal and other age-related diseases: a study protocol

Authors: Kazutoshi Nakamura, Ribeka Takachi, Kaori Kitamura, Toshiko Saito, Ryosaku Kobayashi, Rieko Oshiki, Yumi Watanabe, Keiko Kabasawa, Akemi Takahashi, Shoichiro Tsugane, Masayuki Iki, Ayako Sasaki, Osamu Yamazaki

Published in: Environmental Health and Preventive Medicine | Issue 1/2018

Abstract

Background

Age-related musculoskeletal diseases are becoming increasingly burdensome in terms of both individual quality of life and medical cost. We intended to establish a large population-based cohort study to determine environmental, lifestyle, and genetic risk factors of musculoskeletal and other age-related diseases, and to clarify the association between vitamin D status and such diseases.

Methods

We targeted 34,802 residents aged 40–74 years living in areas of northern Niigata Prefecture, including Sekikawa Village, Awashimaura Village, and Murakami City (Murakami region). The baseline questionnaire survey, conducted between 2011 and 2013, queried respondents on their lifestyle and environmental factors (predictors), and self-reported outcomes. Plasma 25-hydroxyvitamin D (25[OH]D) concentration, an indicator of vitamin D status, was determined with the Liaison® 25OH Vitamin D Total Assay. The primary outcome of this study was osteoporotic fracture; other outcomes included age-related diseases including knee osteoarthritis, perception of chronic pain, dementia, and long-term care insurance use. Mean ages of men and women were 59.2 (SD = 9.3, N = 6907) and 59.0 (SD = 9.3, N = 7457) years, respectively. From the blood samples provided by 3710 men and 4787 women, mean 25(OH)D concentrations were 56.5 (SD = 18.4) nmol/L (22.6 ng/mL) and 45.4 (SD = 16.5) nmol/L (18.2 ng/mL), respectively.

Discussion

Follow-up surveys are planned every 5 years for 15 years, and incident cases of our targeted diseases will be followed at hospitals and clinics in and nearby the cohort area. We anticipate that we will be able to clarify the association between vitamin D status and multiple disease outcomes in a Japanese population.

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Title: The Murakami Cohort Study of vitamin D for the prevention of musculoskeletal and other age-related diseases: a study protocol
Authors: Kazutoshi Nakamura
Ribeka Takachi
Kaori Kitamura
Toshiko Saito
Ryosaku Kobayashi
Rieko Oshiki
Yumi Watanabe
Keiko Kabasawa
Akemi Takahashi
Shoichiro Tsugane
Masayuki Iki
Ayako Sasaki
Osamu Yamazaki
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Environmental Health and Preventive Medicine / Issue 1/2018
Print ISSN: 1342-078X
Electronic ISSN: 1347-4715
DOI: https://doi.org/10.1186/s12199-018-0715-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The Murakami Cohort Study of vitamin D for the prevention of musculoskeletal and other age-related diseases: a study protocol

Abstract

Background

Methods

Discussion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Discussion

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