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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2017

Open Access 01-12-2017 | Review article

Botulinum neurotoxin type A for the treatment of pain: not just in migraine and trigeminal neuralgia

Authors: Giorgio Sandrini, Roberto De Icco, Cristina Tassorelli, Nicola Smania, Stefano Tamburin

Published in: The Journal of Headache and Pain | Issue 1/2017

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Abstract

Background

Despite their huge epidemiological impact, primary headaches, trigeminal neuralgia and other chronic pain conditions still receive suboptimal medical approach, even in developed countries. The limited efficacy of current pain-killers and prophylactic treatments stands among the main reasons for this phenomenon. Botulinum neurotoxin (BoNT) represents a well-established and licensed treatment for chronic migraine, but also an emerging treatment for other types of primary headache, trigeminal neuralgia, neuropathic pain, and an increasing number of pain conditions.

Methods

We searched and critically reviewed evidence for the efficacy of BoNT for the treatment of chronic pain.

Results

Meta-analyses and randomized controlled trials (RCTs) suggest that BoNT potentially represents a multi-purpose drug for the treatment of pain in several disorders due to a favorable safety profile and a long-lasting relief after a single injection.

Conclusions

BoNT is an emerging treatment in different pain conditions. Future RCTs should explore the use of BoNT injection therapy combined with systemic drugs and/or physical therapies as new pain treatment strategies.
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Metadata
Title
Botulinum neurotoxin type A for the treatment of pain: not just in migraine and trigeminal neuralgia
Authors
Giorgio Sandrini
Roberto De Icco
Cristina Tassorelli
Nicola Smania
Stefano Tamburin
Publication date
01-12-2017
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2017
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/s10194-017-0744-z

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