Top

The Journal of Headache and Pain

Published in:

Open Access 01-12-2017 | Research article

Association of excessive daytime sleepiness with migraine and headache frequency in the general population

Authors: Knut Stavem, Håvard Anton Kristiansen, Espen Saxhaug Kristoffersen, Kari Jorunn Kværner, Michael Bjørn Russell

Published in: The Journal of Headache and Pain | Issue 1/2017

Abstract

Background

Some previous studies have postulated an association between migraine and excessive daytime sleepiness (EDS). This study evaluated the association of EDS with migraine and headache frequency in a general population, after adjusting for potential confounding variables.

Methods

The study was a postal survey of a random age and gender-stratified sample of 40,000 persons aged 20 to 80 years old drawn by the National Population Register in Norway. The questionnaire included questions about migraine, headache, the Epworth sleepiness scale (ESS) and various comorbidities. EDS was defined as ESS > 10. The association of EDS and migraine/headache were analysed by bivariate and multivariable logistic regression analyses.

Results

A total of 21,177 persons responded to the ESS and were included in the analyses. The odds ratio (OR) for EDS was increased for migraineurs (1.42 (95% CI 1.31─1.54), p < 0.001) compared to non-migraineurs; however, this finding was not significant after adjustment for a number of possible confounders. EDS increased with increasing headache frequency, with an OR of 2.74 (95% CI 2.05─3.65), p < 0.001) for those with headache on >179 days per year compared to those without headache in multivariable analysis.

Conclusions

In a general population, the odds for EDS increased significantly with the headache frequency, irrespective of migraine status. EDS was not associated with reported migraine in multivariable analysis.

Lyngberg AC, Rasmussen BK, Jorgensen T, Jensen R (2005) Secular changes in health care utilization and work absence for migraine and tension-type headache: a population based study. Eur J Epidemiol 20(12):1007–1014CrossRefPubMed

Russell MB, Rasmussen BK, Thorvaldsen P, Olesen J (1995) Prevalence and sex-ratio of the subtypes of migraine. Int J Epidemiol 24(3):612–618CrossRefPubMed

Russell MB, Levi N, Saltyte-Benth J, Fenger K (2006) Tension-type headache in adolescents and adults: a population based study of 33,764 twins. Eur J Epidemiol 21(2):153–160CrossRefPubMed

Jensen R, Stovner LJ (2008) Epidemiology and comorbidity of headache. Lancet Neurol 7(4):354–361CrossRefPubMed

Grande RB, Aaseth K, Gulbrandsen P, Lundqvist C, Russell MB (2008) Prevalence of primary chronic headache in a population-based sample of 30- to 44-year-old persons. The Akershus study of chronic headache. Neuroepidemiology 30(2):76–83CrossRefPubMed

Mitler MM, Carskadon MA, Czeisler CA, Dement WC, Dinges DF, Graeber RC (1988) Catastrophes, sleep, and public policy: consensus report. Sleep 11(1):100–109PubMedPubMedCentral

Roth T, Roehrs TA (1996) Etiologies and sequelae of excessive daytime sleepiness. Clin Ther 18(4):562–576, discussion 561CrossRefPubMed

Leger D (1994) The cost of sleep-related accidents: a report for the national commission on sleep disorders research. Sleep 17(1):84–93PubMed

Briones B, Adams N, Strauss M, Rosenberg C, Whalen C, Carskadon M, Roebuck T, Winters M, Redline S (1996) Relationship between sleepiness and general health status. Sleep 19(7):583–588PubMed

10.

Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S (1993) The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328(17):1230–1235CrossRefPubMed

11.

Duran J, Esnaola S, Rubio R, Iztueta A (2001) Obstructive sleep apnea-hypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 yr. Am J Respir Crit Care Med 163(3 Pt 1):685–689CrossRefPubMed

12.

Bixler EO, Vgontzas AN, Lin HM, Calhoun SL, Vela-Bueno A, Kales A (2005) Excessive daytime sleepiness in a general population sample: the role of sleep apnea, age, obesity, diabetes, and depression. J Clin Endocrinol Metab 90(8):4510–4515CrossRefPubMed

13.

Stradling JR, Barbour C, Glennon J, Langford BA, Crosby JH (2000) Prevalence of sleepiness and its relation to autonomic evidence of arousals and increased inspiratory effort in a community based population of men and women. J Sleep Res 9(4):381–388CrossRefPubMed

14.

Stiefel F, Stagno D (2004) Management of insomnia in patients with chronic pain conditions. CNS Drugs 18(5):285–296CrossRefPubMed

15.

Young TB (2004) Epidemiology of daytime sleepiness: definitions, symptomatology, and prevalence. J Clin Psychiatry 65(Suppl 16):12–16PubMed

16.

Leger D, Poursain B, Neubauer D, Uchiyama M (2008) An international survey of sleeping problems in the general population. Curr Med Res Opin 24(1):307–317CrossRefPubMed

17.

Peres MF, Stiles MA, Siow HC, Silberstein SD (2005) Excessive daytime sleepiness in migraine patients. J Neurol Neurosurg Psychiatry 76(10):1467–1468CrossRefPubMedPubMedCentral

18.

Barbanti P, Fabbrini G, Aurilia C, Vanacore N, Cruccu G (2007) A case–control study on excessive daytime sleepiness in episodic migraine. Cephalalgia 27(10):1115–1119CrossRefPubMed

19.

Seidel S, Hartl T, Weber M, Matterey S, Paul A, Riederer F, Gharabaghi M, Wober-Bingol C, Wober C (2009) Quality of sleep, fatigue and daytime sleepiness in migraine - a controlled study. Cephalalgia 29(6):662–669CrossRefPubMed

20.

Barbanti P, Aurilia C, Egeo G, Fofi L, Vanacore N (2013) A case–control study on excessive daytime sleepiness in chronic migraine. Sleep Med 14(3):278–281CrossRefPubMed

21.

Ødegård SS, Engstrøm M, Sand T, Stovner LJ, Zwart JA, Hagen K (2010) Associations between sleep disturbance and primary headaches: the third Nord-Trondelag Health Study. J Headache Pain 11(3):197–206CrossRefPubMedPubMedCentral

22.

Kim J, Cho SJ, Kim WJ, Yang KI, Yun CH, Chu MK (2016) Excessive daytime sleepiness is associated with an exacerbation of migraine: A population-based study. J Headache Pain 17(1):62CrossRefPubMedPubMedCentral

23.

Russell MB, Kristiansen HA, Saltyte-Benth J, Kvaerner KJ (2008) A cross-sectional population-based survey of migraine and headache in 21,177 Norwegians: the Akershus sleep apnea project. J Headache Pain 9(6):339–347CrossRefPubMedPubMedCentral

24.

Society HCSotIH (2004) The International Classification of Headache Disorders: 2nd edition. Cephalalgia 24(Suppl 1):9–160

25.

Johns MW (1991) A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 14(6):540–545CrossRefPubMed

26.

Johns MW (1994) Sleepiness in different situations measured by the Epworth Sleepiness Scale. Sleep 17(8):703–710PubMed

27.

Beiske KK, Kjelsberg FN, Ruud EA, Stavem K (2009) Reliability and validity of a Norwegian version of the Epworth sleepiness scale. Sleep Breath 13(1):65–72CrossRefPubMed

28.

Whooley MA, Avins AL, Miranda J, Browner WS (1997) Case-finding instruments for depression. Two questions are as good as many. J Gen Intern Med 12(7):439–445CrossRefPubMedPubMedCentral

29.

Pallesen S, Nordhus IH, Omvik S, Sivertsen B, Tell GS, Bjorvatn B (2007) Prevalence and risk factors of subjective sleepiness in the general adult population. Sleep 30(5):619–624PubMed

30.

Vgontzas A, Cui L, Merikangas KR (2008) Are sleep difficulties associated with migraine attributable to anxiety and depression? Headache 48(10):1451–1459CrossRefPubMedPubMedCentral

31.

Ancoli-Israel S, Roth T (1999) Characteristics of insomnia in the united states: results of the 1991 national sleep foundation survey. I. Sleep 22(Suppl 2):S347–353PubMed

32.

Johns MW, Hocking B (1997) Daytime sleepiness and sleep habits of Australian workers. Sleep 20(10):844–849PubMed

33.

Gander PH, Marshall NS, Harris R, Reid P (2005) The Epworth sleepiness scale: influence of age, ethnicity, and socioeconomic deprivation. Epworth sleepiness scores of adults in New Zealand. Sleep 28(2):249–253PubMed

34.

Sanford SD, Lichstein KL, Durrence HH, Riedel BW, Taylor DJ, Bush AJ (2006) The influence of age, gender, ethnicity, and insomnia on Epworth sleepiness scores: a normative US population. Sleep Med 7(4):319–326CrossRefPubMed

35.

Sander C, Hegerl U, Wirkner K, Walter N, Kocalevent RD, Petrowski K, Glaesmer H, Hinz A (2016) Normative values of the Epworth sleepiness scale (ESS), derived from a large German sample. Sleep Breath 20(4):1337–1345CrossRefPubMed

36.

Johns MW (1992) Reliability and factor analysis of the Epworth sleepiness scale. Sleep 15(4):376–381PubMed

37.

Olson LG, Cole MF, Ambrogetti A (1998) Correlations among Epworth sleepiness scale scores, multiple sleep latency tests and psychological symptoms. J Sleep Res 7(4):248–253CrossRefPubMed

38.

Chervin RD, Aldrich MS (1999) The Epworth Sleepiness Scale may not reflect objective measures of sleepiness or sleep apnea. Neurology 52(1):125–131CrossRefPubMed

39.

Furuta H, Kaneda R, Kosaka K, Arai H, Sano J, Koshino Y (1999) Epworth sleepiness scale and sleep studies in patients with obstructive sleep apnea syndrome. Psychiatry Clin Neurosci 53(2):301–302CrossRefPubMed

40.

Rasmussen BK, Jensen R, Olesen J (1991) Questionnaire versus clinical interview in the diagnosis of headache. Headache 31:290–295CrossRefPubMed

Title: Association of excessive daytime sleepiness with migraine and headache frequency in the general population
Authors: Knut Stavem
Håvard Anton Kristiansen
Espen Saxhaug Kristoffersen
Kari Jorunn Kværner
Michael Bjørn Russell
Publication date: 01-12-2017
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 1/2017
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/s10194-017-0743-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association of excessive daytime sleepiness with migraine and headache frequency in the general population

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2017

The association of headache frequency with pain interference and the burden of disease is mediated by depression and sleep quality, but not anxiety, in chronic tension type headache

Perceived stress in patients with migraine: a case-control study

De novo exonic duplication of ATP1A2 in Italian patient with hemiplegic migraine: a case report

Brain networking analysis in migraine with and without aura

Erratum to: Psychiatric comorbidities and photophobia in patients with migraine

The effect and safety of monoclonal antibodies to calcitonin gene-related peptide and its receptor on migraine: a systematic review and meta-analysis