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The Journal of Headache and Pain

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Open Access 01-12-2017 | Short report

The relationship between right-to-left shunt and brain white matter lesions in Japanese patients with migraine: a single center study

Authors: Akio Iwasaki, Keisuke Suzuki, Hidehiro Takekawa, Ryotaro Takashima, Ayano Suzuki, Shiho Suzuki, Koichi Hirata

Published in: The Journal of Headache and Pain | Issue 1/2017

Abstract

Background

There may be a link between right-to-left shunt (RLs) and brain white matter lesions (WMLs) in patients with migraine. In this study, we assessed the relationship between WMLs and RLs in Japanese migraine patients.

Methods

A total of 107 consecutive patients with migraine with (MA) and without aura (MWOA) were included in this study. Contrast transcranial Doppler ultrasound was used to detect RLs. WMLs were graded using brain magnetic resonance imaging based on well-established criteria.

Findings

The prevalence of RLs was significantly increased in the WMLs positive group (n = 24) compared with the WMLs negative group (n = 83) (75.0% vs. 47.0%, p = 0.015). In prevalence of WMLs between MA and MWOA patients, there were no statistical differences (p = 0.410). Logistic regression analysis adjusted by age and disease duration of migraine identified an RLs-positive status as the sole determinant for the presence of WMLs (OR = 6.15; 95% CI 1.82–20.8; p = 0.003)

Conclusion

Our study suggests a possible link between RLs and WMLs in Japanese patients with migraine.

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Title: The relationship between right-to-left shunt and brain white matter lesions in Japanese patients with migraine: a single center study
Authors: Akio Iwasaki
Keisuke Suzuki
Hidehiro Takekawa
Ryotaro Takashima
Ayano Suzuki
Shiho Suzuki
Koichi Hirata
Publication date: 01-12-2017
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 1/2017
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/s10194-016-0714-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The relationship between right-to-left shunt and brain white matter lesions in Japanese patients with migraine: a single center study

Abstract

Background

Methods

Findings

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Findings

Conclusion

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