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The Journal of Headache and Pain

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Open Access 01-12-2016 | Research article

Lack of association between cluster headache and PER3 clock gene polymorphism

Authors: Hilde K. Ofte, Erling Tronvik, Karl B. Alstadhaug

Published in: The Journal of Headache and Pain | Issue 1/2015

Abstract

Background

Cluster headache (CH) is regarded as a chronobiological disorder. The hypothalamic biological clock may thus be involved in the pathophysiology, but few studies have actually investigated this in CH patients. A variable number tandem repeat (VNTR) polymorphism of the PER3 clock gene has been associated to preferred daily rhythm (chronotype) in several studies. We aimed to study the distribution of PER3 VNTR polymorphisms and chronotypes in a CH population.

Methods

We used blood samples from a biobank of CH patients for genetic tests, and invited all tested patients to complete the Horne-Ostberg Morningness-eveningness Questionnaire (MEQ), the Pittsburgh sleep quality Index (PSQI) and the Shift Work Index. Genotypes were compared to a previously tested population of 432 healthy students.

Results

One hundred forty nine patients were genotyped, and we found no difference in PER3 VNTR polymorphisms between patients and controls. Seventy-four patients completed the MEQ (54 men, 20 women, mean age 52.3 years ± 13.4), and chronotypes were as follows: 12 % morning-, 37 % intermediate-, and 51 % evening types. Compared with a previous Danish study of CH patients and controls, there were no difference in chronotype distribution. Sixty percent of patients were defined as bad sleepers (PSQI >5), and 51 % of patients currently employed were shift workers.

Conclusions

No association between CH, PER3 VNTR polymorphism and chronotype was found in this study.

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Title: Lack of association between cluster headache and PER3 clock gene polymorphism
Authors: Hilde K. Ofte
Erling Tronvik
Karl B. Alstadhaug
Publication date: 01-12-2016
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 1/2015
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/s10194-016-0611-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Lack of association between cluster headache and PER3 clock gene polymorphism

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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