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Respiratory Research
Published in: Respiratory Research 3/2001

Open Access 01-06-2001 | Review

Eotaxin and the attraction of eosinophils to the asthmatic lung

Authors: Dolores M Conroy, Timothy J Williams

Published in: Respiratory Research | Issue 3/2001

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Abstract

Eosinophilic leukocytes accumulate in high numbers in the lungs of asthmatic patients, and are believed to be important in the pathogenisis of asthma. A potent eosinophil chemoattractant is produced in the asthmatic lung. This small protein, the chemokine eotaxin, is synthesized by a number of different cell types, and is stimulated by interleukin-4 and interleukin-13, which are produced by T-helper (Th)2 lymphocytes. Low molecular weight compounds have been developed that can block the eotaxin receptor C-C chemokine receptor (CCR)3, and prevent stimulation by eotaxin. This provides the potential for orally available drugs that can prevent eosinophil recruitment into the lung and the associated damage and dysfunction.
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Metadata
Title
Eotaxin and the attraction of eosinophils to the asthmatic lung
Authors
Dolores M Conroy
Timothy J Williams
Publication date
01-06-2001
Publisher
BioMed Central
Published in
Respiratory Research / Issue 3/2001
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/rr52

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