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Respiratory Research
Published in: Respiratory Research 2/2001

Open Access 01-04-2001 | Review

Role of endothelin-1 in lung disease

Authors: Karen A Fagan, MD, Ivan F McMurtry, David M Rodman

Published in: Respiratory Research | Issue 2/2001

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Abstract

Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of smooth muscle tone, and inflammatory mediator that may play a key role in diseases of the airways, pulmonary circulation, and inflammatory lung diseases, both acute and chronic. This review will focus on the biology of ET-1 and its role in lung disease.
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Metadata
Title
Role of endothelin-1 in lung disease
Authors
Karen A Fagan, MD
Ivan F McMurtry
David M Rodman
Publication date
01-04-2001
Publisher
BioMed Central
Published in
Respiratory Research / Issue 2/2001
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/rr44

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