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Respiratory Research
Published in: Respiratory Research 1/2001

Open Access 01-12-2001 | Commentary

Growth factors in lung development and disease: friends or foe?

Authors: Tushar J Desai, Wellington V Cardoso

Published in: Respiratory Research | Issue 1/2001

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Abstract

Growth factors mediate tissue interactions and regulate a variety of cellular functions that are critical for normal lung development and homeostasis. Besides their involvement in lung pattern formation, growth and cell differentiation during organogenesis, these factors have been also implicated in modulating injury-repair responses of the adult lung. Altered expression of growth factors, such as transforming growth factor β1, vascular endothelial growth factor and epidermal growth factor, and/or their receptors, has been found in a number of pathological lung conditions. In this paper, we discuss the dual role of these molecules in mediating beneficial feedback responses or responses that can further damage lung integrity; we shall also discuss the basis for their prospective use as therapeutic agents.
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Metadata
Title
Growth factors in lung development and disease: friends or foe?
Authors
Tushar J Desai
Wellington V Cardoso
Publication date
01-12-2001
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2001
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/rr169

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