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Open Access 01-06-2010 | Research

Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection

Authors: Charalambos Gogos, Antigone Kotsaki, Aimilia Pelekanou, George Giannikopoulos, Ilia Vaki, Panagiota Maravitsa, Stephanos Adamis, Zoi Alexiou, George Andrianopoulos, Anastasia Antonopoulou, Sofia Athanassia, Fotini Baziaka, Aikaterini Charalambous, Sofia Christodoulou, Ioanna Dimopoulou, Ioannis Floros, Efthymia Giannitsioti, Panagiotis Gkanas, Aikaterini Ioakeimidou, Kyriaki Kanellakopoulou, Niki Karabela, Vassiliki Karagianni, Ioannis Katsarolis, Georgia Kontopithari, Petros Kopterides, Ioannis Koutelidakis, Pantelis Koutoukas, Hariklia Kranidioti, Michalis Lignos, Konstantinos Louis, Korina Lymberopoulou, Efstratios Mainas, Androniki Marioli, Charalambos Massouras, Irini Mavrou, Margarita Mpalla, Martha Michalia, Heleni Mylona, Vassilios Mytas, Ilias Papanikolaou, Konstantinos Papanikolaou, Maria Patrani, Ioannis Perdios, Diamantis Plachouras, Aikaterini Pistiki, Konstantinos Protopapas, Kalliopi Rigaki, Vissaria Sakka, Monika Sartzi, Vassilios Skouras, Maria Souli, Aikaterini Spyridaki, Ioannis Strouvalis, Thomas Tsaganos, George Zografos, Konstantinos Mandragos, Phylis Klouva-Molyvdas, Nina Maggina, Helen Giamarellou, Apostolos Armaganidis, Evangelos J Giamarellos-Bourboulis

Published in: Critical Care | Issue 3/2010

Abstract

Introduction

Although major changes of the immune system have been described in sepsis, it has never been studied whether these may differ in relation to the type of underlying infection or not. This was studied for the first time.

Methods

The statuses of the innate and adaptive immune systems were prospectively compared in 505 patients. Whole blood was sampled within less than 24 hours of advent of sepsis; white blood cells were stained with monoclonal antibodies and analyzed though a flow cytometer.

Results

Expression of HLA-DR was significantly decreased among patients with severe sepsis/shock due to acute pyelonephritis and intraabdominal infections compared with sepsis. The rate of apoptosis of natural killer (NK) cells differed significantly among patients with severe sepsis/shock due to ventilator-associated pneumonia (VAP) and hospital-acquired pneumonia (HAP) compared with sepsis. The rate of apoptosis of NKT cells differed significantly among patients with severe sepsis/shock due to acute pyelonephritis, primary bacteremia and VAP/HAP compared with sepsis. Regarding adaptive immunity, absolute counts of CD4-lymphocytes were significantly decreased among patients with severe sepsis/shock due to community-acquired pneumonia (CAP) and intraabdominal infections compared with sepsis. Absolute counts of B-lymphocytes were significantly decreased among patients with severe sepsis/shock due to CAP compared with sepsis.

Conclusions

Major differences of the early statuses of the innate and adaptive immune systems exist between sepsis and severe sepsis/shock in relation to the underlying type of infection. These results may have a major impact on therapeutics.

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Title: Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection
Authors: Charalambos Gogos
Antigone Kotsaki
Aimilia Pelekanou
George Giannikopoulos
Ilia Vaki
Panagiota Maravitsa
Stephanos Adamis
Zoi Alexiou
George Andrianopoulos
Anastasia Antonopoulou
Sofia Athanassia
Fotini Baziaka
Aikaterini Charalambous
Sofia Christodoulou
Ioanna Dimopoulou
Ioannis Floros
Efthymia Giannitsioti
Panagiotis Gkanas
Aikaterini Ioakeimidou
Kyriaki Kanellakopoulou
Niki Karabela
Vassiliki Karagianni
Ioannis Katsarolis
Georgia Kontopithari
Petros Kopterides
Ioannis Koutelidakis
Pantelis Koutoukas
Hariklia Kranidioti
Michalis Lignos
Konstantinos Louis
Korina Lymberopoulou
Efstratios Mainas
Androniki Marioli
Charalambos Massouras
Irini Mavrou
Margarita Mpalla
Martha Michalia
Heleni Mylona
Vassilios Mytas
Ilias Papanikolaou
Konstantinos Papanikolaou
Maria Patrani
Ioannis Perdios
Diamantis Plachouras
Aikaterini Pistiki
Konstantinos Protopapas
Kalliopi Rigaki
Vissaria Sakka
Monika Sartzi
Vassilios Skouras
Maria Souli
Aikaterini Spyridaki
Ioannis Strouvalis
Thomas Tsaganos
George Zografos
Konstantinos Mandragos
Phylis Klouva-Molyvdas
Nina Maggina
Helen Giamarellou
Apostolos Armaganidis
Evangelos J Giamarellos-Bourboulis
Publication date: 01-06-2010
Publisher: BioMed Central
Published in: Critical Care / Issue 3/2010
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc9031

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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