Published in:
01-06-2008 | Commentary
Moving beyond tight glucose control to safe effective glucose control
Authors:
James S Krinsley, Jean-Charles Preiser
Published in:
Critical Care
|
Issue 3/2008
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Abstract
The impressive benefits related to the use of tight glucose control by intensive insulin therapy have not been reproduced until now in multicenter large-scale prospective randomized trials. Although the reasons for these failures are not entirely clear, we suggest the use of a stepwise approach – Safe, Effective Glucose Control – that will essentially target an intermediate blood glucose level. As compared with genuine tight glucose control, Safe, Effective Glucose Control – already used in many intensive care units worldwide – is intended to decrease the rate of hypoglycemia and the workload, while reducing the adverse effects of severe hyperglycemia.