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Open Access 01-04-2008 | Research

Diagnosis of ventilator-associated pneumonia: a systematic review of the literature

Authors: Alvaro Rea-Neto, Nazah Cherif M Youssef, Fabio Tuche, Frank Brunkhorst, V Marco Ranieri, Konrad Reinhart, Yasser Sakr

Published in: Critical Care | Issue 2/2008

Abstract

Introduction

Early, accurate diagnosis is fundamental in the management of patients with ventilator-associated pneumonia (VAP). The aim of this qualitative review was to compare various criteria of diagnosing VAP in the intensive care unit (ICU) with a special emphasis on the value of clinical diagnosis, microbiological culture techniques, and biomarkers of host response.

Methods

A MEDLINE search was performed using the keyword 'ventilator associated pneumonia' AND 'diagnosis'. Our search was limited to human studies published between January 1966 and June 2007. Only studies of at least 25 adult patients were included. Predefined variables were collected, including year of publication, study design (prospective/retrospective), number of patients included, and disease group.

Results

Of 572 articles fulfilling the initial search criteria, 159 articles were chosen for detailed review of the full text. A total of 64 articles fulfilled the inclusion criteria and were included in our review. Clinical criteria, used in combination, may be helpful in diagnosing VAP, however, the considerable inter-observer variability and the moderate performance should be taken in account. Bacteriologic data do not increase the accuracy of diagnosis as compared to clinical diagnosis. Quantitative cultures obtained by different methods seem to be rather equivalent in diagnosing VAP. Blood cultures are relatively insensitive to diagnose pneumonia. The rapid availability of cytological data, including inflammatory cells and Gram stains, may be useful in initial therapeutic decisions in patients with suspected VAP. C-reactive protein, procalcitonin, and soluble triggering receptor expressed on myeloid cells are promising biomarkers in diagnosing VAP.

Conclusion

An integrated approach should be followed in diagnosing and treating patients with VAP, including early antibiotic therapy and subsequent rectification according to clinical response and results of bacteriologic cultures.

Available only for authorised users

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Title: Diagnosis of ventilator-associated pneumonia: a systematic review of the literature
Authors: Alvaro Rea-Neto
Nazah Cherif M Youssef
Fabio Tuche
Frank Brunkhorst
V Marco Ranieri
Konrad Reinhart
Yasser Sakr
Publication date: 01-04-2008
Publisher: BioMed Central
Published in: Critical Care / Issue 2/2008
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc6877

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Diagnosis of ventilator-associated pneumonia: a systematic review of the literature

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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