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Critical Care
Published in: Critical Care 2/2008

01-04-2008 | Poster presentation

Arginine reduces leukocyte/endothelial cell interaction in a model of normotensive endotoxemia without attenuating capillary perfusion failure

Authors: J Fertmann, M Laschke, B Vollmar, MD Menger, JN Hoffmann

Published in: Critical Care | Special Issue 2/2008

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Excerpt

Sepsis and septic multiorgan failure are still associated with a high mortality. Recent pathophysiological studies could show that a substantial depletion of the semi-essential amino acid arginine occurs during sepsis. However, the effects of a high-dosed supplementation of L-arginine on the microcirculation have not been well characterised. This study addresses the effect of an intravenous L-arginine application on the microcirculation in a well-established model of normotensive endotoxemia. …
Metadata
Title
Arginine reduces leukocyte/endothelial cell interaction in a model of normotensive endotoxemia without attenuating capillary perfusion failure
Authors
J Fertmann
M Laschke
B Vollmar
MD Menger
JN Hoffmann
Publication date
01-04-2008
Publisher
BioMed Central
Published in
Critical Care / Issue Special Issue 2/2008
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc6368

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