Published in:
01-08-2007 | Poster presentation
Selective V1a receptor agonists in experimental septic shock
Author:
Daniel Traber
Published in:
Critical Care
|
Special Issue 4/2007
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Excerpt
Septic shock is caused by hypotension secondary to vasodilation. This hypotension is resistant to fluid resuscitation and requires the use of vasopressor agents. Recently, it was shown that it may be due to a deficiency in the vasopressor hormone arginine–vasopressin (AVP), a mixed V1a/V2 receptor agonist, leading to the clinical use of AVP in septic shock. We tested the hypothesis that the selective V1a receptor agonist FE 202158 is at least as effective as AVP in a sheep model of pneumonia-induced septic shock. …