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Published in: Critical Care 3/1999

01-06-1999 | Review

Agitation in the ICU: part one Anatomical and physiologic basis for the agitated state

Author: David Crippen

Published in: Critical Care | Issue 3/1999

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Excerpt

The term 'agitation' describes a syndrome of excessive motor activity, usually nonpurposeful and associated with internal tension. For intensivists, agitation is not so much a diagnosis, but a consequence of more fundamental etiologies that, when expressed, result in disquietude. Agitation is important in the intensive care unit (ICU) because it can alter the diagnosis and course of medical treatment. It can cloud the etiology of underlying disease processes like a smoke screen, making effective diagnosis difficult or impossible. It may result in the inability of the patient to cooperate with monitoring and therapeutics that requires them to lie relatively still and quiet. Treatment of agitation without considering underlying causation gives the false impression of wellness when in reality end-organ damage is occurring either as a result of agitation itself, or as a result of exacerbation of underlying pathology. …
Literature
1.
go back to reference Davidson RJ, Irwin W: The functional neuroanatomy of emotion and affective style. Trends Cogn Sci 1999, 3: 11-21. 10.1016/S1364-6613(98)01265-0PubMed Davidson RJ, Irwin W: The functional neuroanatomy of emotion and affective style. Trends Cogn Sci 1999, 3: 11-21. 10.1016/S1364-6613(98)01265-0PubMed
2.
go back to reference Kropotov JD, Etlinger SC: Selection of actions in the basal gangliathalamocortical circuits: review and model. Int J Psychophysiol 1999, 31: 197-217. 10.1016/S0167-8760(98)00051-8PubMed Kropotov JD, Etlinger SC: Selection of actions in the basal gangliathalamocortical circuits: review and model. Int J Psychophysiol 1999, 31: 197-217. 10.1016/S0167-8760(98)00051-8PubMed
3.
go back to reference Reid SG, Milsom WK: Respiratory pattern formation in the isolated bullfrog (Rana catesbeiana) brainstem-spinal cord. Respir Physiol 1998, 114: 239-255. 10.1016/S0034-5687(98)00091-7PubMed Reid SG, Milsom WK: Respiratory pattern formation in the isolated bullfrog (Rana catesbeiana) brainstem-spinal cord. Respir Physiol 1998, 114: 239-255. 10.1016/S0034-5687(98)00091-7PubMed
4.
go back to reference Barrera-Mera B, Barrera-Calva E: The Cartesian clock metaphor for pineal gland operation pervades the origin of modern chronobiology. Neurosci Biobehav Rev 1998, 23: 1-4. 10.1016/S0149-7634(97)00062-6PubMed Barrera-Mera B, Barrera-Calva E: The Cartesian clock metaphor for pineal gland operation pervades the origin of modern chronobiology. Neurosci Biobehav Rev 1998, 23: 1-4. 10.1016/S0149-7634(97)00062-6PubMed
6.
go back to reference Smythies J: The functional neuroanatomy of awareness: with a focus on the role of various anatomical systems in the control of intermodal attention. Conscious Cogn 1997, 6: 455-458. 10.1006/ccog.1997.0315PubMed Smythies J: The functional neuroanatomy of awareness: with a focus on the role of various anatomical systems in the control of intermodal attention. Conscious Cogn 1997, 6: 455-458. 10.1006/ccog.1997.0315PubMed
7.
go back to reference Philip Strange: Brain Biochemistry and Brain Disorders. Oxford: Oxford University Press; 1992. Philip Strange: Brain Biochemistry and Brain Disorders. Oxford: Oxford University Press; 1992.
8.
go back to reference Fischer JE, Rosen HM, Ebeid AM, et al.: The effect of normalization of plasma amino acids on hepatic encephalopathy in man. Surgery 1976, 80: 77-91.PubMed Fischer JE, Rosen HM, Ebeid AM, et al.: The effect of normalization of plasma amino acids on hepatic encephalopathy in man. Surgery 1976, 80: 77-91.PubMed
9.
go back to reference Settipane GA: The restaurant syndromes. N Engl Reg Allergy Proc 1987, 8: 39-46.PubMed Settipane GA: The restaurant syndromes. N Engl Reg Allergy Proc 1987, 8: 39-46.PubMed
10.
go back to reference McConalogue K, Grady EF, Minnis J, et al.: Activation and internalization of the mu-opioid receptor by the newly discovered endogenous agonists, endomorphin-1 and endomorphin-2. Neuroscience 1999, 90: 1051-1059. 10.1016/S0306-4522(98)00514-4PubMedCentralPubMed McConalogue K, Grady EF, Minnis J, et al.: Activation and internalization of the mu-opioid receptor by the newly discovered endogenous agonists, endomorphin-1 and endomorphin-2. Neuroscience 1999, 90: 1051-1059. 10.1016/S0306-4522(98)00514-4PubMedCentralPubMed
11.
go back to reference Devaud LL, Morrow AL: Gender-selective effects of ethanol dependence on NMDA receptor subunit expression in cerebral cortex, hippocampus and hypothalamus. Eur J Pharmacol 1999, 369: 331-334. 10.1016/S0014-2999(99)00103-XPubMed Devaud LL, Morrow AL: Gender-selective effects of ethanol dependence on NMDA receptor subunit expression in cerebral cortex, hippocampus and hypothalamus. Eur J Pharmacol 1999, 369: 331-334. 10.1016/S0014-2999(99)00103-XPubMed
12.
go back to reference Bonci A, Malenka RC: Properties and plasticity of excitatory synapses on dopaminergic and GABAergic cells in the ventral tegmental area. Neurosci 1999, 19: 3723-3730. Bonci A, Malenka RC: Properties and plasticity of excitatory synapses on dopaminergic and GABAergic cells in the ventral tegmental area. Neurosci 1999, 19: 3723-3730.
13.
go back to reference Holt RA, Bateson AN, Martin IL: Decreased GABA enhancement of benzodiazepine binding after a single dose of diazepam. J Neurochem 1999, 72: 2219-2222. 10.1046/j.1471-4159.1999.0722219.xPubMed Holt RA, Bateson AN, Martin IL: Decreased GABA enhancement of benzodiazepine binding after a single dose of diazepam. J Neurochem 1999, 72: 2219-2222. 10.1046/j.1471-4159.1999.0722219.xPubMed
14.
go back to reference Crippen DW, Ermakov S: Stress, agitation and brain failure in critical care medicine. Crit Care Q 1992, 15: 52-74. Crippen DW, Ermakov S: Stress, agitation and brain failure in critical care medicine. Crit Care Q 1992, 15: 52-74.
15.
go back to reference Rusnak M, Zorad S, Buckendahl P, et al.: Tyrosine hydroxylase mRNA levels in locus ceruleus of rats during adaptation to long-term immobilization stress exposure. Mol Chem Neuropathol 1998, 33: 249-258.PubMed Rusnak M, Zorad S, Buckendahl P, et al.: Tyrosine hydroxylase mRNA levels in locus ceruleus of rats during adaptation to long-term immobilization stress exposure. Mol Chem Neuropathol 1998, 33: 249-258.PubMed
16.
go back to reference Dunn AJ: Stress-related changes in cerebral catecholamine and indoleamine metabolism: lack of effect of adrenalectomy and corticosterone. J Neurochem 1988, 51: 406-412.PubMed Dunn AJ: Stress-related changes in cerebral catecholamine and indoleamine metabolism: lack of effect of adrenalectomy and corticosterone. J Neurochem 1988, 51: 406-412.PubMed
17.
go back to reference Schafers RF, Nurnberger J, Herrmann B, et al.: Adrenoceptors mediating the cardiovascular and metabolic effects of α -methylnoradrenaline in humans. J Pharmacol Exp Ther 1999, 289: 918-925.PubMed Schafers RF, Nurnberger J, Herrmann B, et al.: Adrenoceptors mediating the cardiovascular and metabolic effects of α -methylnoradrenaline in humans. J Pharmacol Exp Ther 1999, 289: 918-925.PubMed
18.
go back to reference Fontana A, Rosenheck R: A model of war zone stressors and post-traumatic stress disorder. J Trauma Stress 1999, 12: 111-126. 10.1023/A:1024750417154PubMed Fontana A, Rosenheck R: A model of war zone stressors and post-traumatic stress disorder. J Trauma Stress 1999, 12: 111-126. 10.1023/A:1024750417154PubMed
19.
go back to reference Crippen DW: The role of sedation in the ICU patient with pain and agitation. Crit Care Clin 1990, 6: 369-392.PubMed Crippen DW: The role of sedation in the ICU patient with pain and agitation. Crit Care Clin 1990, 6: 369-392.PubMed
20.
go back to reference Bagley J, Moghaddam B: Temporal dynamics of glutamate efflux in the prefrontal cortex and in the hippocampus following repeated stress: effects of pretreatment with saline or diazepam. Neuroscience 1997, 77: 65-73. 10.1016/S0306-4522(96)00435-6PubMed Bagley J, Moghaddam B: Temporal dynamics of glutamate efflux in the prefrontal cortex and in the hippocampus following repeated stress: effects of pretreatment with saline or diazepam. Neuroscience 1997, 77: 65-73. 10.1016/S0306-4522(96)00435-6PubMed
21.
go back to reference Middleton HC: Panic disorder: a theoretical synthesis of medical and psychological approaches. J Psychosom Res 1998, 44: 121-132. 10.1016/S0022-3999(97)00208-0PubMed Middleton HC: Panic disorder: a theoretical synthesis of medical and psychological approaches. J Psychosom Res 1998, 44: 121-132. 10.1016/S0022-3999(97)00208-0PubMed
22.
go back to reference Crippen DW: Pharmacologic treatment of brain failure and delirium. Crit Care Clin 1994, 10: 733-766.PubMed Crippen DW: Pharmacologic treatment of brain failure and delirium. Crit Care Clin 1994, 10: 733-766.PubMed
23.
24.
go back to reference Szabo ST, de Montigny C, Blier P: Modulation of noradrenergic neuronal firing by selective serotonin reuptake blockers. Br J Pharmacol 1999, 126: 568-571.PubMedCentralPubMed Szabo ST, de Montigny C, Blier P: Modulation of noradrenergic neuronal firing by selective serotonin reuptake blockers. Br J Pharmacol 1999, 126: 568-571.PubMedCentralPubMed
25.
go back to reference Buerk DG, Osanai S, Mokashi A, Lahiri S.: Dopamine, sensory discharge, and stimulus interaction with CO 2 and O 2 in cat carotidbody. Appl Physiol 1998, 85: 1719-1726. Buerk DG, Osanai S, Mokashi A, Lahiri S.: Dopamine, sensory discharge, and stimulus interaction with CO 2 and O 2 in cat carotidbody. Appl Physiol 1998, 85: 1719-1726.
26.
go back to reference Langston P, Gorman D, Runciman W, et al.: The effect of carbon monoxide on oxygen metabolism in the brains of awake sheep. Toxicology 1996, 114: 223-232. 10.1016/S0300-483X(96)03513-5PubMed Langston P, Gorman D, Runciman W, et al.: The effect of carbon monoxide on oxygen metabolism in the brains of awake sheep. Toxicology 1996, 114: 223-232. 10.1016/S0300-483X(96)03513-5PubMed
27.
go back to reference Griez E, Schruers K: Experimental pathophysiology of panic. Psychosom Res 1998, 45: 493-503. 10.1016/S0022-3999(98)00027-0 Griez E, Schruers K: Experimental pathophysiology of panic. Psychosom Res 1998, 45: 493-503. 10.1016/S0022-3999(98)00027-0
28.
go back to reference Zangen A, Overstreet DH, Yadid G: Increased catecholamine levels in specific brain regions of a rat model of depression: normalization by chronic antidepressant treatment. Brain Res 1999, 824: 243-250. 10.1016/S0006-8993(99)01214-7PubMed Zangen A, Overstreet DH, Yadid G: Increased catecholamine levels in specific brain regions of a rat model of depression: normalization by chronic antidepressant treatment. Brain Res 1999, 824: 243-250. 10.1016/S0006-8993(99)01214-7PubMed
29.
go back to reference Castellano C, Cabib S, Puglisi-Allegra S, et al.: Strain-dependent involvement of D 1 and D 2 dopamine receptors in muscarinic cholinergic influences on memory storage. Behav Brain Res 1999, 98: 17-26. 10.1016/S0166-4328(98)00046-1PubMed Castellano C, Cabib S, Puglisi-Allegra S, et al.: Strain-dependent involvement of D 1 and D 2 dopamine receptors in muscarinic cholinergic influences on memory storage. Behav Brain Res 1999, 98: 17-26. 10.1016/S0166-4328(98)00046-1PubMed
30.
go back to reference Horger BA, Iyasere CA, Berhow MT, et al.: Enhancement of locomotor activity and conditioned reward to cocaine by brain-derived neurotrophic factor. J Neurosci 1999, 19: 4110-4122.PubMed Horger BA, Iyasere CA, Berhow MT, et al.: Enhancement of locomotor activity and conditioned reward to cocaine by brain-derived neurotrophic factor. J Neurosci 1999, 19: 4110-4122.PubMed
31.
go back to reference Basso AM, Gioino G, Molina VA, et al.: Chronic amphetamine facilitates immunosuppression in response to a novel aversive stimulus: reversal by haloperidol pretreatment. Pharmacol Biochem Behav 1999, 62: 307-314. 10.1016/S0091-3057(98)00166-XPubMed Basso AM, Gioino G, Molina VA, et al.: Chronic amphetamine facilitates immunosuppression in response to a novel aversive stimulus: reversal by haloperidol pretreatment. Pharmacol Biochem Behav 1999, 62: 307-314. 10.1016/S0091-3057(98)00166-XPubMed
32.
go back to reference Iturriaga R, Alcayaga J, Zapata P: Dissociation of hypoxia-induced chemosensory responses and catecholamine efflux in cat carotid body superfused in vitro. J Physiol (Lond) 1996, 497: 551-564. Iturriaga R, Alcayaga J, Zapata P: Dissociation of hypoxia-induced chemosensory responses and catecholamine efflux in cat carotid body superfused in vitro. J Physiol (Lond) 1996, 497: 551-564.
33.
go back to reference Harrison PJ: The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 1999, 122: 593-624. 10.1093/brain/122.4.593PubMed Harrison PJ: The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 1999, 122: 593-624. 10.1093/brain/122.4.593PubMed
34.
go back to reference Miller NE, Lipowski JZ, Lebowitz BD: Delirium: Advances in research and Clinical Practice. New York: Springer; 1991. Miller NE, Lipowski JZ, Lebowitz BD: Delirium: Advances in research and Clinical Practice. New York: Springer; 1991.
35.
go back to reference Crippen DW: Neurologic monitoring in the intensive care unit. New Horizons 1994, 2: 107-120.PubMed Crippen DW: Neurologic monitoring in the intensive care unit. New Horizons 1994, 2: 107-120.PubMed
36.
go back to reference Crippen D: Understanding neurohumoral causes of anxiety in the ICU. J Crit Ill 1995, 10: 550-560. Crippen D: Understanding neurohumoral causes of anxiety in the ICU. J Crit Ill 1995, 10: 550-560.
37.
go back to reference Settle EC, Ayd FJ: Haloperidol: a quarter century of experience. J Clin Psychiatry 1983, 44: 440-448.PubMed Settle EC, Ayd FJ: Haloperidol: a quarter century of experience. J Clin Psychiatry 1983, 44: 440-448.PubMed
38.
go back to reference Tesar GE, Murray GB, Cassem NH: Use of haloperidol for acute delirium in intensive care setting. J Clin Psychopharmacol 1985, 5: 344-347.PubMed Tesar GE, Murray GB, Cassem NH: Use of haloperidol for acute delirium in intensive care setting. J Clin Psychopharmacol 1985, 5: 344-347.PubMed
39.
go back to reference Todd CL, Grace AA: Interaction of benztropine and haloperidol actions on rat substantia nigra dopamine cell electrophysiological activity in vivo. Brain Res Bull 1999, 48: 219-222. 10.1016/S0361-9230(98)00166-XPubMed Todd CL, Grace AA: Interaction of benztropine and haloperidol actions on rat substantia nigra dopamine cell electrophysiological activity in vivo. Brain Res Bull 1999, 48: 219-222. 10.1016/S0361-9230(98)00166-XPubMed
40.
go back to reference Wagner BK, O'Hara DA, Hammond JS: Drugs for amnesia in the ICU. Am J Crit Care 1997, 6: 192-203.PubMed Wagner BK, O'Hara DA, Hammond JS: Drugs for amnesia in the ICU. Am J Crit Care 1997, 6: 192-203.PubMed
41.
go back to reference Gerlach J, Larsen EB: Subjective experience and mental side-effects of antipsychotic treatment. Acta Psychiatr Scand Suppl 1999, 395: 113-117.PubMed Gerlach J, Larsen EB: Subjective experience and mental side-effects of antipsychotic treatment. Acta Psychiatr Scand Suppl 1999, 395: 113-117.PubMed
42.
go back to reference Rosebush PI, Mazurek MF: Neurologic side effects in neuroleptic-naive patients treated with haloperidol or risperidone. Neurology 1999, 52: 782-785.PubMed Rosebush PI, Mazurek MF: Neurologic side effects in neuroleptic-naive patients treated with haloperidol or risperidone. Neurology 1999, 52: 782-785.PubMed
43.
go back to reference Cannon JT, Lewis JW, Weinberg VE, et al.: Evidence for the independence of brainstem mechanisms mediating analgesia induced by morphine and two forms of stress. Brain Res 1983, 269: 231-236. 10.1016/0006-8993(83)90132-4PubMed Cannon JT, Lewis JW, Weinberg VE, et al.: Evidence for the independence of brainstem mechanisms mediating analgesia induced by morphine and two forms of stress. Brain Res 1983, 269: 231-236. 10.1016/0006-8993(83)90132-4PubMed
44.
go back to reference Rosow C: Agonist-antagonist opioids: theory and clinical practice. Can J Anaesth 1989, 36: S5-8.PubMed Rosow C: Agonist-antagonist opioids: theory and clinical practice. Can J Anaesth 1989, 36: S5-8.PubMed
45.
go back to reference Hughes J, Woodruff GN: Neuropeptides. Function and clinical applications. Arzneimittelforschung 1992, 42: 250-255.PubMed Hughes J, Woodruff GN: Neuropeptides. Function and clinical applications. Arzneimittelforschung 1992, 42: 250-255.PubMed
46.
go back to reference Field MJ, Carnell AJ, Gonzalez MI, et al.: Enadoline, a selective kappa-opioid receptor agonist shows potent antihyperalgesic and antiallodynic actions in a rat model of surgical pain. Pain 1999, 80: 383-389. 10.1016/S0304-3959(98)00237-1PubMed Field MJ, Carnell AJ, Gonzalez MI, et al.: Enadoline, a selective kappa-opioid receptor agonist shows potent antihyperalgesic and antiallodynic actions in a rat model of surgical pain. Pain 1999, 80: 383-389. 10.1016/S0304-3959(98)00237-1PubMed
47.
go back to reference Watkins LR, Wiertelak EP, McGorry M, et al.: Neurocircuitry of conditioned inhibition of analgesia: effects of amygdala, dorsal raphe, ventral medullary, and spinal cord lesions on antianalgesia in the rat. Behav Neurosci 1998, 112: 360-378. 10.1037//0735-7044.112.2.360PubMed Watkins LR, Wiertelak EP, McGorry M, et al.: Neurocircuitry of conditioned inhibition of analgesia: effects of amygdala, dorsal raphe, ventral medullary, and spinal cord lesions on antianalgesia in the rat. Behav Neurosci 1998, 112: 360-378. 10.1037//0735-7044.112.2.360PubMed
48.
go back to reference Furst S: Transmitters involved in antinociception in the spinal cord. Brain Res Bull 1999, 48: 129-141. 10.1016/S0361-9230(98)00159-2PubMed Furst S: Transmitters involved in antinociception in the spinal cord. Brain Res Bull 1999, 48: 129-141. 10.1016/S0361-9230(98)00159-2PubMed
49.
go back to reference Sahni R, Menegazzi JJ, Mosesso VN Jr: Paramedic evaluation of clinical indicators of cervical spinal injury. Prehosp Emerg Care 1997, 1: 16-18.PubMed Sahni R, Menegazzi JJ, Mosesso VN Jr: Paramedic evaluation of clinical indicators of cervical spinal injury. Prehosp Emerg Care 1997, 1: 16-18.PubMed
50.
go back to reference Riedel W, Layka H, Neeck G: Secretory pattern of GH, TSH, thyroid hormones, ACTH, cortisol, FSH, and LH in patients with fibromyalgia syndrome following systemic injection of the relevant hypothalamic-releasing hormones. Rheumatol 1998, 57 (suppl 2): 81-87. 10.1007/s003930050242 Riedel W, Layka H, Neeck G: Secretory pattern of GH, TSH, thyroid hormones, ACTH, cortisol, FSH, and LH in patients with fibromyalgia syndrome following systemic injection of the relevant hypothalamic-releasing hormones. Rheumatol 1998, 57 (suppl 2): 81-87. 10.1007/s003930050242
51.
go back to reference King SM: Escape-related behaviours in an unstable, elevated and exposed environment. II. Long-term sensitization after repetitive electrical stimulation of the rodent midbrain defence system. Behav Brain Res 1999, 98: 127-142. 10.1016/S0166-4328(98)00061-8PubMed King SM: Escape-related behaviours in an unstable, elevated and exposed environment. II. Long-term sensitization after repetitive electrical stimulation of the rodent midbrain defence system. Behav Brain Res 1999, 98: 127-142. 10.1016/S0166-4328(98)00061-8PubMed
52.
go back to reference Wang TL, Chang H, Hung CR, et al.: Morphine preconditioning attenuates neutrophil activation in rat models of myocardial infarction. Cardiovasc Res 1998, 40: 557-563. 10.1016/S0008-6363(98)00192-8PubMed Wang TL, Chang H, Hung CR, et al.: Morphine preconditioning attenuates neutrophil activation in rat models of myocardial infarction. Cardiovasc Res 1998, 40: 557-563. 10.1016/S0008-6363(98)00192-8PubMed
53.
go back to reference Schlaepfer TE, Strain EC, Greenberg BD, et al.: Site of opioid action in the human brain: mu and kappa agonists' subjective and cerebral blood flow effects. Am J Psychiatry 1998, 155: 470-473.PubMed Schlaepfer TE, Strain EC, Greenberg BD, et al.: Site of opioid action in the human brain: mu and kappa agonists' subjective and cerebral blood flow effects. Am J Psychiatry 1998, 155: 470-473.PubMed
54.
go back to reference Janal MN, Colt EW, Clark WC, Glusman M: Pain sensitivity, mood and plasma endocrine levels in man following long-distance running: effects of naloxone. Pain 1984, 19: 13-25. 10.1016/0304-3959(84)90061-7PubMed Janal MN, Colt EW, Clark WC, Glusman M: Pain sensitivity, mood and plasma endocrine levels in man following long-distance running: effects of naloxone. Pain 1984, 19: 13-25. 10.1016/0304-3959(84)90061-7PubMed
56.
go back to reference Arief AI, Griggs RC: Metabolic Brain Dysfunction in Systemic Disorders.Boston: Little, Brown Co.; 1992. Arief AI, Griggs RC: Metabolic Brain Dysfunction in Systemic Disorders.Boston: Little, Brown Co.; 1992.
57.
go back to reference Casadevall M, Saperas E, Panes J, et al.: Mechanisms underlying the anti-inflammatory actions of central corticotropin-releasing factor. Am J Physiol 1999, 276: G1016-G1026.PubMed Casadevall M, Saperas E, Panes J, et al.: Mechanisms underlying the anti-inflammatory actions of central corticotropin-releasing factor. Am J Physiol 1999, 276: G1016-G1026.PubMed
58.
go back to reference Ignar DM, Kuhn CM: Effects of specific mu and kappa opiate tolerance and abstinence on hypothalamo-pituitary-adrenal axis secretion in the rat. Pharmacol Exp Ther 1990, 255: 1287-1295. Ignar DM, Kuhn CM: Effects of specific mu and kappa opiate tolerance and abstinence on hypothalamo-pituitary-adrenal axis secretion in the rat. Pharmacol Exp Ther 1990, 255: 1287-1295.
59.
go back to reference Marti O, Harbuz MS, Andres R, et al.: Activation of the hypothalamic–pituitary axis in adrenalectomised rats: potentiation by chronic stress. Brian Res 1999, 821: 1-7. 10.1016/S0006-8993(98)01212-8 Marti O, Harbuz MS, Andres R, et al.: Activation of the hypothalamic–pituitary axis in adrenalectomised rats: potentiation by chronic stress. Brian Res 1999, 821: 1-7. 10.1016/S0006-8993(98)01212-8
60.
go back to reference Marti O, Harbuz MS, Andres R, et al.: Activation of the hypothalamic-pituitary axis in adrenalectomised rats: potentiation by chronic stress. Brain Res 1999, 821: 1-7. 10.1016/S0006-8993(98)01212-8PubMed Marti O, Harbuz MS, Andres R, et al.: Activation of the hypothalamic-pituitary axis in adrenalectomised rats: potentiation by chronic stress. Brain Res 1999, 821: 1-7. 10.1016/S0006-8993(98)01212-8PubMed
61.
go back to reference Bremner JD: Does stress damage the brain? Biol Psychiatry 1999, 45: 797-805. 10.1016/S0006-3223(99)00009-8PubMed Bremner JD: Does stress damage the brain? Biol Psychiatry 1999, 45: 797-805. 10.1016/S0006-3223(99)00009-8PubMed
62.
go back to reference Hashimoto K, Suemaru S, Takao T, et al.: Corticotropin-releasing hormone and pituitary–adrenocortical responses in chronically stressed rats. Regul Pept 1988, 23: 117-126. 10.1016/0167-0115(88)90019-5PubMed Hashimoto K, Suemaru S, Takao T, et al.: Corticotropin-releasing hormone and pituitary–adrenocortical responses in chronically stressed rats. Regul Pept 1988, 23: 117-126. 10.1016/0167-0115(88)90019-5PubMed
63.
go back to reference To CT, Bagdy G: Anxiogenic effect of central CCK administration is attenuated by chronic fluoxetine or ipsapirone treatment. Neuropharmacology 1999, 38: 279-282. 10.1016/S0028-3908(98)00176-2PubMed To CT, Bagdy G: Anxiogenic effect of central CCK administration is attenuated by chronic fluoxetine or ipsapirone treatment. Neuropharmacology 1999, 38: 279-282. 10.1016/S0028-3908(98)00176-2PubMed
64.
go back to reference Hotta M, Shibasaki T, Arai K, et al.: Corticotropin-releasing factor receptor type 1 mediates emotional stress-induced inhibition of food intake and behavioral changes in rats. Brain Res 1999, 823: 221-225. 10.1016/S0006-8993(99)01177-4PubMed Hotta M, Shibasaki T, Arai K, et al.: Corticotropin-releasing factor receptor type 1 mediates emotional stress-induced inhibition of food intake and behavioral changes in rats. Brain Res 1999, 823: 221-225. 10.1016/S0006-8993(99)01177-4PubMed
65.
go back to reference Marshall SB, Marshall LF, . Neuroscience Critical Care: Pathophysiology and Patient Management. Philadelphia: WB Saunders; 1990. Marshall SB, Marshall LF, . Neuroscience Critical Care: Pathophysiology and Patient Management. Philadelphia: WB Saunders; 1990.
66.
go back to reference Arnsten AF: Catecholamine regulation of the prefrontal cortex. Psychopharmacology 1997, 11: 151-162. Arnsten AF: Catecholamine regulation of the prefrontal cortex. Psychopharmacology 1997, 11: 151-162.
67.
go back to reference Gorman AL, Dunn AJ: β-Adrenergic receptors are involved in stress-related behavioral changes. Pharmacol Biochem Behav 1993, 45: 1-7. 10.1016/0091-3057(93)90078-8PubMed Gorman AL, Dunn AJ: β-Adrenergic receptors are involved in stress-related behavioral changes. Pharmacol Biochem Behav 1993, 45: 1-7. 10.1016/0091-3057(93)90078-8PubMed
68.
go back to reference Khasar SG, McCarter G, Levine JD: Epinephrine produces a β-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors. J Neurophysiol 1999, 81: 1104-1112.PubMed Khasar SG, McCarter G, Levine JD: Epinephrine produces a β-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors. J Neurophysiol 1999, 81: 1104-1112.PubMed
69.
go back to reference Gray AM: Effect of alprazolam on opiate withdrawal: a combined behavioural and microdialysis study. Eur J Pharmacol 1996, 313: 73-77. 10.1016/0014-2999(96)00599-7PubMed Gray AM: Effect of alprazolam on opiate withdrawal: a combined behavioural and microdialysis study. Eur J Pharmacol 1996, 313: 73-77. 10.1016/0014-2999(96)00599-7PubMed
70.
go back to reference Sidebotham D, Dijkhuizen MR, Schug SA: The safety and utilization of patient-controlled analgesia. Pain Symptom Manage 1997, 14: 202-209. 10.1016/S0885-3924(97)00182-6 Sidebotham D, Dijkhuizen MR, Schug SA: The safety and utilization of patient-controlled analgesia. Pain Symptom Manage 1997, 14: 202-209. 10.1016/S0885-3924(97)00182-6
71.
go back to reference Gan TJ, Ginsberg B, Glass PS, et al.: Opioid-sparing effects of a low-dose infusion of naloxone in patient-administered morphine sulfate. Anesthesiology 1997, 87: 1075-1081. 10.1097/00000542-199711000-00011PubMed Gan TJ, Ginsberg B, Glass PS, et al.: Opioid-sparing effects of a low-dose infusion of naloxone in patient-administered morphine sulfate. Anesthesiology 1997, 87: 1075-1081. 10.1097/00000542-199711000-00011PubMed
72.
go back to reference Katcher J, Walsh D: Opioid-induced itching: morphine sulfate and hydromorphone hydrochloride. Pain Symptom Manage 1999, 17: 70-72. 10.1016/S0885-3924(98)00115-8 Katcher J, Walsh D: Opioid-induced itching: morphine sulfate and hydromorphone hydrochloride. Pain Symptom Manage 1999, 17: 70-72. 10.1016/S0885-3924(98)00115-8
73.
go back to reference Fleischmann E, Akca O, Wallner T, et al.: Onset time, recovery duration, and drug cost with four different methods of inducing general anesthesia. Anesth Analg 1999, 88: 930-935.PubMed Fleischmann E, Akca O, Wallner T, et al.: Onset time, recovery duration, and drug cost with four different methods of inducing general anesthesia. Anesth Analg 1999, 88: 930-935.PubMed
74.
go back to reference Byun MY, Fine NA, Lee JY, et al.: The clinical outcome of abdominoplasty performed under conscious sedation: increased use of fentanyl correlated with longer stay in outpatient unit. Plast Reconstr Surg 1999, 103: 1260-1266.PubMed Byun MY, Fine NA, Lee JY, et al.: The clinical outcome of abdominoplasty performed under conscious sedation: increased use of fentanyl correlated with longer stay in outpatient unit. Plast Reconstr Surg 1999, 103: 1260-1266.PubMed
75.
go back to reference Jung D, Mroszczak E, Bynum L: Pharmacokinetics of ketorolac in humans after intravenous, intramuscular and oral administration. Eur J Clin Pharmacol 1988, 35: 423-425.PubMed Jung D, Mroszczak E, Bynum L: Pharmacokinetics of ketorolac in humans after intravenous, intramuscular and oral administration. Eur J Clin Pharmacol 1988, 35: 423-425.PubMed
76.
go back to reference Bravo LJ, Mattie H, Spierdijk J: The effects on ventilation of ketorolac in comparison with morphine. Eur J Clin Pharmacol 1988, 35: 491-494.PubMed Bravo LJ, Mattie H, Spierdijk J: The effects on ventilation of ketorolac in comparison with morphine. Eur J Clin Pharmacol 1988, 35: 491-494.PubMed
77.
go back to reference Barvais L, Dejonckheere M, Dernovoi B, et al.: Continuous infusion of midazolam or bolus of diazepam for postoperative sedation cardiac surgical patients. Acta Anaesthesiol Belgica 1988, 39:: 239-245. Barvais L, Dejonckheere M, Dernovoi B, et al.: Continuous infusion of midazolam or bolus of diazepam for postoperative sedation cardiac surgical patients. Acta Anaesthesiol Belgica 1988, 39:: 239-245.
78.
go back to reference Behne M, Asskali F, Steuer , et al.: Continuous midazolam infusion for sedation of respirator patients. Anesthetist 1987, 36: 228-232. Behne M, Asskali F, Steuer , et al.: Continuous midazolam infusion for sedation of respirator patients. Anesthetist 1987, 36: 228-232.
79.
go back to reference Coenen AM, van Luijtelaar EL: Effects of benzodiazepines, sleep and sleep deprivation on vigilance and memory. Acta Neurol Belg 1997, 97: 123-129.PubMed Coenen AM, van Luijtelaar EL: Effects of benzodiazepines, sleep and sleep deprivation on vigilance and memory. Acta Neurol Belg 1997, 97: 123-129.PubMed
80.
go back to reference Shafer A: Complications of sedation with midazolam in the intensive care unit and a comparison with other sedative regimens. Crit Care Med 1998, 26: 947-956. 10.1097/00003246-199805000-00034PubMed Shafer A: Complications of sedation with midazolam in the intensive care unit and a comparison with other sedative regimens. Crit Care Med 1998, 26: 947-956. 10.1097/00003246-199805000-00034PubMed
81.
go back to reference Nordt SP, Clark RF: Midazolam: a review of therapeutic uses and toxicity. Emerg Med 1997, 15: 357-365. 10.1016/S0736-4679(97)00022-X Nordt SP, Clark RF: Midazolam: a review of therapeutic uses and toxicity. Emerg Med 1997, 15: 357-365. 10.1016/S0736-4679(97)00022-X
82.
go back to reference Sperlagh B, Sershen H, Lajtha A, et al.: Co-release of endogenous ATP and [ 3 H]noradrenaline from rat hypothalamic slices: origin and modulation by α 2 - adrenoceptors. Neuroscience 1998, 82: 511-520. 10.1016/S0306-4522(97)00306-0PubMed Sperlagh B, Sershen H, Lajtha A, et al.: Co-release of endogenous ATP and [ 3 H]noradrenaline from rat hypothalamic slices: origin and modulation by α 2 - adrenoceptors. Neuroscience 1998, 82: 511-520. 10.1016/S0306-4522(97)00306-0PubMed
83.
go back to reference Boher H, Bach A, Layer M, et al.: Clonidine as a sedative adjunct. Intensive Care Med 1990, 16: 265-266. Boher H, Bach A, Layer M, et al.: Clonidine as a sedative adjunct. Intensive Care Med 1990, 16: 265-266.
84.
go back to reference Kulkarni SK, Parale MP, Kulkarni GK: Clonidine in alcohol withdrawal: a clinical report. Methods Find Exp Clin Pharmacol 1987, 9: 697-698.PubMed Kulkarni SK, Parale MP, Kulkarni GK: Clonidine in alcohol withdrawal: a clinical report. Methods Find Exp Clin Pharmacol 1987, 9: 697-698.PubMed
85.
go back to reference Nutt D, Glue P, Molyneux S, et al.: α-2-Adrenoceptor function in alcohol withdrawal: a pilot study of the effects of iv. clonidine in alcoholics and normals. Alcohol Clin Exp Res 1988, 12: 14-18.PubMed Nutt D, Glue P, Molyneux S, et al.: α-2-Adrenoceptor function in alcohol withdrawal: a pilot study of the effects of iv. clonidine in alcoholics and normals. Alcohol Clin Exp Res 1988, 12: 14-18.PubMed
86.
go back to reference Wing LM, Reid JL, Hamilton CA, et al.: Effects of clonidine on biochemical indices of sympathetic function in normotensive man. Clin Sci Mol Med 1977, 53: 45-53.PubMed Wing LM, Reid JL, Hamilton CA, et al.: Effects of clonidine on biochemical indices of sympathetic function in normotensive man. Clin Sci Mol Med 1977, 53: 45-53.PubMed
87.
go back to reference Ghignone M, Quintin L, Kehler CH, et al.: Effects of clonidine on narcotic requirements and hemodynamic response during indduction of fentanyl anesthesia and endotracheal intubation. Anesthesiology 1986, 64: 36-42.PubMed Ghignone M, Quintin L, Kehler CH, et al.: Effects of clonidine on narcotic requirements and hemodynamic response during indduction of fentanyl anesthesia and endotracheal intubation. Anesthesiology 1986, 64: 36-42.PubMed
88.
go back to reference Coombs DW, Saunders RL, Fratkin JD, et al.: Continuous intrathecal hydromorphone and clonidine for tractable cancer pain. J Neurosurg 1986, 64: 890-894.PubMed Coombs DW, Saunders RL, Fratkin JD, et al.: Continuous intrathecal hydromorphone and clonidine for tractable cancer pain. J Neurosurg 1986, 64: 890-894.PubMed
89.
go back to reference Cushman PJ, Sowers JR: Alcohol withdrawal syndrome: clinical and hormonal responses to α-2 adrenergic treatment. Alcoholism 1989, 13: 361-364.PubMed Cushman PJ, Sowers JR: Alcohol withdrawal syndrome: clinical and hormonal responses to α-2 adrenergic treatment. Alcoholism 1989, 13: 361-364.PubMed
90.
go back to reference Hokfelt B, Hedeland H, Hasson BG: The effect of clonidine and penbutol, respectively on catecholamines in blood and urine, plasma renin activity and urinary aldosterone in hypertensive patients. Arch Int Pharmacodyn 1975, 213: 307-321.PubMed Hokfelt B, Hedeland H, Hasson BG: The effect of clonidine and penbutol, respectively on catecholamines in blood and urine, plasma renin activity and urinary aldosterone in hypertensive patients. Arch Int Pharmacodyn 1975, 213: 307-321.PubMed
91.
go back to reference Toon S, Hopkins KJ, Aarons L, Rowland M: Rate and extent of absorption of clonidine from a transdermal therapeutic system. J Pharm Pharmacol 1989, 41: 17-21.PubMed Toon S, Hopkins KJ, Aarons L, Rowland M: Rate and extent of absorption of clonidine from a transdermal therapeutic system. J Pharm Pharmacol 1989, 41: 17-21.PubMed
92.
go back to reference Bernard JM, Hommeril JL, Passuti N, Pinaud M: Postoperative analgesia by intravenous clonidine. Anesthesiology 1991, 75: 577-582.PubMed Bernard JM, Hommeril JL, Passuti N, Pinaud M: Postoperative analgesia by intravenous clonidine. Anesthesiology 1991, 75: 577-582.PubMed
93.
go back to reference Aantaa RE, Kanto JH, Scheinin M: Dexmedetomidine premedication for minor gynecologic surgery. Anesth Analg 1990, 4: 407-413. Aantaa RE, Kanto JH, Scheinin M: Dexmedetomidine premedication for minor gynecologic surgery. Anesth Analg 1990, 4: 407-413.
94.
go back to reference Aantaa RE, Kanto JH: Dexmedotomidine, an α 2 -adrenoceptor agonist, reduces anesthetic requirements for patients undergoing minor gynecologic surgery. Anesthesiology 1990, 73: 230-235.PubMed Aantaa RE, Kanto JH: Dexmedotomidine, an α 2 -adrenoceptor agonist, reduces anesthetic requirements for patients undergoing minor gynecologic surgery. Anesthesiology 1990, 73: 230-235.PubMed
95.
go back to reference Lane R, Baldwin D: Selective serotonin reuptake inhibitor-induced serotonin syndrome [review]. J Clin Psychopharmacol 1997, 17: 208-221. 10.1097/00004714-199706000-00012PubMed Lane R, Baldwin D: Selective serotonin reuptake inhibitor-induced serotonin syndrome [review]. J Clin Psychopharmacol 1997, 17: 208-221. 10.1097/00004714-199706000-00012PubMed
96.
go back to reference Silver H, Shmugliakov N: Augmentation with fluvoxamine but not maprotiline improves negative symptoms in treated schizophrenia: evidence for a specific serotonergic effect from a double-blind study. J Clin Psychopharmacol 1998, 18: 208-211. 10.1097/00004714-199806000-00005PubMed Silver H, Shmugliakov N: Augmentation with fluvoxamine but not maprotiline improves negative symptoms in treated schizophrenia: evidence for a specific serotonergic effect from a double-blind study. J Clin Psychopharmacol 1998, 18: 208-211. 10.1097/00004714-199806000-00005PubMed
97.
go back to reference Davidson C, Stamford JA: Evidence that 5-hydroxytryptamine release in rat dorsal raphe nucleus is controlled by 5-HT 1 A , 5-HT 1 B and 5-HT 1 D autoreceptors. Br J Pharmacol 1995, 114: 1107-1109.PubMedCentralPubMed Davidson C, Stamford JA: Evidence that 5-hydroxytryptamine release in rat dorsal raphe nucleus is controlled by 5-HT 1 A , 5-HT 1 B and 5-HT 1 D autoreceptors. Br J Pharmacol 1995, 114: 1107-1109.PubMedCentralPubMed
98.
go back to reference Hery F, Boulenguez P, Semont A, et al.: Identification and role of serotonin 5-HT 1A and 5-HT 1B receptors in primary cultures of rat embryonic rostral raphe nucleus neurons. Neurochem 1999, 72: 1791-1801. 10.1046/j.1471-4159.1999.0721791.x Hery F, Boulenguez P, Semont A, et al.: Identification and role of serotonin 5-HT 1A and 5-HT 1B receptors in primary cultures of rat embryonic rostral raphe nucleus neurons. Neurochem 1999, 72: 1791-1801. 10.1046/j.1471-4159.1999.0721791.x
99.
go back to reference Yocca FD: Neurochemistry and neurophysiology of buspirone and gepirone: interactions at presynaptic and postsynaptic 5-HT1A receptors. Clin Psychopharmacol 1990, 10 (suppl 3): 6S-12S. Yocca FD: Neurochemistry and neurophysiology of buspirone and gepirone: interactions at presynaptic and postsynaptic 5-HT1A receptors. Clin Psychopharmacol 1990, 10 (suppl 3): 6S-12S.
100.
go back to reference Hashimoto T, Hamada C, Wada T, et al.: Comparative study on the behavioral and EEG changes induced by diazepam, buspirone and a novel anxioselective anxiolytic, DN- in the cat. Neuropsychobiology 1992, 26: 89-99.PubMed Hashimoto T, Hamada C, Wada T, et al.: Comparative study on the behavioral and EEG changes induced by diazepam, buspirone and a novel anxioselective anxiolytic, DN- in the cat. Neuropsychobiology 1992, 26: 89-99.PubMed
101.
go back to reference Kato M, Kajimura N, Okuma T, et al.: Association between delta waves during sleep and negative symptoms in schizophrenia.Pharmaco-EEG studies by using structurally different hypnotics. Neuropsychobiology 1999, 39: 165-172. 10.1159/000026577PubMed Kato M, Kajimura N, Okuma T, et al.: Association between delta waves during sleep and negative symptoms in schizophrenia.Pharmaco-EEG studies by using structurally different hypnotics. Neuropsychobiology 1999, 39: 165-172. 10.1159/000026577PubMed
102.
go back to reference Yoshimoto M, Higuchi H, Kamata M, et al.: The effects of benzodiazepine (triazolam), cyclopyrrolone (zopiclone) and imidazopyridine (zolpidem) hypnotics on the frequency of hippocampal theta activity and sleep structure in rats. Eur Neuropsychopharmacol 1999, 9: 29-35. 10.1016/S0924-977X(97)00102-8PubMed Yoshimoto M, Higuchi H, Kamata M, et al.: The effects of benzodiazepine (triazolam), cyclopyrrolone (zopiclone) and imidazopyridine (zolpidem) hypnotics on the frequency of hippocampal theta activity and sleep structure in rats. Eur Neuropsychopharmacol 1999, 9: 29-35. 10.1016/S0924-977X(97)00102-8PubMed
103.
go back to reference Lancel M: Role of GABAA receptors in the regulation of sleep: initial sleep responses to peripherally administered modulators and agonists. Sleep 1999, 22: 33-42.PubMed Lancel M: Role of GABAA receptors in the regulation of sleep: initial sleep responses to peripherally administered modulators and agonists. Sleep 1999, 22: 33-42.PubMed
104.
go back to reference Strohle A, Antonijevic IA, Steiger A, et al.: Dependency of non-benzodiazepine hypnotics. Two case reports. Nervenarzt 1999, 70: 72-75. 10.1007/s001150050403PubMed Strohle A, Antonijevic IA, Steiger A, et al.: Dependency of non-benzodiazepine hypnotics. Two case reports. Nervenarzt 1999, 70: 72-75. 10.1007/s001150050403PubMed
105.
go back to reference Concas A, Serra M, Santoro G, et al.: The effect of cyclopyrrolones on GABA A receptor function is different from that of benzodiazepines. Naunyn Schmiedebergs Arch Pharmacol 1994, 350: 294-300.PubMed Concas A, Serra M, Santoro G, et al.: The effect of cyclopyrrolones on GABA A receptor function is different from that of benzodiazepines. Naunyn Schmiedebergs Arch Pharmacol 1994, 350: 294-300.PubMed
106.
go back to reference Wong G, Uusi-Oukari M, Hansen HC, et al.: Characterization of novel ligands for wild-type and natural mutant diazepam-insensitive benzodiazepine receptors. Eur J Pharmacol 1995, 289: 335-342. 10.1016/0922-4106(95)90111-6PubMed Wong G, Uusi-Oukari M, Hansen HC, et al.: Characterization of novel ligands for wild-type and natural mutant diazepam-insensitive benzodiazepine receptors. Eur J Pharmacol 1995, 289: 335-342. 10.1016/0922-4106(95)90111-6PubMed
107.
go back to reference Revel L, Mennuni L, Garofalo P, et al.: CR 2945: a novel CCKB receptor antagonist with anxiolytic-like activity. Behav Pharmacol 1998, 9: 183-194.PubMed Revel L, Mennuni L, Garofalo P, et al.: CR 2945: a novel CCKB receptor antagonist with anxiolytic-like activity. Behav Pharmacol 1998, 9: 183-194.PubMed
108.
go back to reference Maletinska L, Pirkova J, Hlavacek J, et al.: Cholecystokinin analogs with suppressed central activities. Peptides 1998, 19: 301-308. 10.1016/S0196-9781(97)00371-9PubMed Maletinska L, Pirkova J, Hlavacek J, et al.: Cholecystokinin analogs with suppressed central activities. Peptides 1998, 19: 301-308. 10.1016/S0196-9781(97)00371-9PubMed
109.
go back to reference Dethloff LA, Barr BM, Bestervelt LL: Inhibition of gastrin-stimulated cell proliferation by the CCK-B/gastrin receptor ligand CI-988. Food Chem Toxicol 1999, 37: 105-110. 10.1016/S0278-6915(98)00119-7PubMed Dethloff LA, Barr BM, Bestervelt LL: Inhibition of gastrin-stimulated cell proliferation by the CCK-B/gastrin receptor ligand CI-988. Food Chem Toxicol 1999, 37: 105-110. 10.1016/S0278-6915(98)00119-7PubMed
110.
go back to reference Acosta GB: Administration of cholecystokinin sulphated octapeptide (CCK-8S) induces changes on rat amino acid tissue levels and on a behavioral test for anxiety. Gen Pharmacol 1998, 31: 637-641. 10.1016/S0306-3623(98)00075-5PubMed Acosta GB: Administration of cholecystokinin sulphated octapeptide (CCK-8S) induces changes on rat amino acid tissue levels and on a behavioral test for anxiety. Gen Pharmacol 1998, 31: 637-641. 10.1016/S0306-3623(98)00075-5PubMed
111.
go back to reference Lofberg C, Agren H, Harro J, et al.: Cholecystokinin in CSF from depressed patients: possible relations to severity of depression and suicidal behaviour. Eur Neuropsychopharmacol 1998, 8: 153-157. 10.1016/S0924-977X(97)00046-1PubMed Lofberg C, Agren H, Harro J, et al.: Cholecystokinin in CSF from depressed patients: possible relations to severity of depression and suicidal behaviour. Eur Neuropsychopharmacol 1998, 8: 153-157. 10.1016/S0924-977X(97)00046-1PubMed
112.
go back to reference Crespi F: Cholecystokinin-B (CCK-B) receptor antagonists improve 'aged' sleep: a new class of sleep modulators? Methods Find Exp Clin Pharmacol 1999, 21: 31-38.PubMed Crespi F: Cholecystokinin-B (CCK-B) receptor antagonists improve 'aged' sleep: a new class of sleep modulators? Methods Find Exp Clin Pharmacol 1999, 21: 31-38.PubMed
113.
go back to reference Singh L, Field MJ, Hughes J, et al.: The behavioural properties of CI-988, a selective cholecystokininB receptor antagonist. Br J Pharmacol 1991, 104: 239-245.PubMedCentralPubMed Singh L, Field MJ, Hughes J, et al.: The behavioural properties of CI-988, a selective cholecystokininB receptor antagonist. Br J Pharmacol 1991, 104: 239-245.PubMedCentralPubMed
114.
go back to reference Brawman-Mintzer O, Lydiard RB, Bradwejn J, et al.: Effects of the cholecystokinin agonist pentagastrin in patients with generalized anxiety disorder. Am J Psychiatry 1997, 154: 700-702.PubMed Brawman-Mintzer O, Lydiard RB, Bradwejn J, et al.: Effects of the cholecystokinin agonist pentagastrin in patients with generalized anxiety disorder. Am J Psychiatry 1997, 154: 700-702.PubMed
115.
go back to reference Biro E, Sarnyai Z, Penke B, et al.: Role of endogenous corticotropin-releasing factor in mediation of neuroendocrine and behavioral responses to cholecystokinin octapeptide sulfate ester in rats. Neuroendocrinology 1993, 57: 340-345.PubMed Biro E, Sarnyai Z, Penke B, et al.: Role of endogenous corticotropin-releasing factor in mediation of neuroendocrine and behavioral responses to cholecystokinin octapeptide sulfate ester in rats. Neuroendocrinology 1993, 57: 340-345.PubMed
116.
go back to reference Singh L, Field MJ, Hill DR, et al.: Peptoid CCK receptor antagonists: pharmacological evaluation of CCKA, CCKB and mixed CCKA/B receptor antagonists. Eur J Pharmacol 1995, 286: 185-191. 10.1016/0014-2999(95)00445-QPubMed Singh L, Field MJ, Hill DR, et al.: Peptoid CCK receptor antagonists: pharmacological evaluation of CCKA, CCKB and mixed CCKA/B receptor antagonists. Eur J Pharmacol 1995, 286: 185-191. 10.1016/0014-2999(95)00445-QPubMed
117.
go back to reference Ohtsuka T, Nakayama N, Itezono Y, et al.: Tetronothiodin, a novel cholecystokinin type-B receptor antagonist produced by Streptomyces sp. NR0489. III. Structural elucidation. J Antibiot (Tokyo) 1993, 46: 18-24. Ohtsuka T, Nakayama N, Itezono Y, et al.: Tetronothiodin, a novel cholecystokinin type-B receptor antagonist produced by Streptomyces sp. NR0489. III. Structural elucidation. J Antibiot (Tokyo) 1993, 46: 18-24.
Metadata
Title
Agitation in the ICU: part one Anatomical and physiologic basis for the agitated state
Author
David Crippen
Publication date
01-06-1999
Publisher
BioMed Central
Published in
Critical Care / Issue 3/1999
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc348

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