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Critical Care
Published in: Critical Care 1/2005

01-02-2004 | Review

Bench-to-bedside review: Apoptosis/programmed cell death triggered by traumatic brain injury

Authors: Xiaopeng Zhang, Yaming Chen, Larry W Jenkins, Patrick M Kochanek, Robert SB Clark

Published in: Critical Care | Issue 1/2005

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Abstract

Apoptosis, or programmed cell death, is a physiological form of cell death that is important for normal embryologic development and cell turnover in adult organisms. Cumulative evidence suggests that apoptosis can also be triggered in tissues without a high rate of cell turnover, including those within the central nervous system (CNS). In fact, a crucial role for apoptosis in delayed neuronal loss after both acute and chronic CNS injury is emerging. In the current review we summarize the growing evidence that apoptosis occurs after traumatic brain injury (TBI), from experimental models to humans. This includes the identification of apoptosis after TBI, initiators of apoptosis, key modulators of apoptosis such as the Bcl-2 family, key executioners of apoptosis such as the caspase family, final pathways of apoptosis, and potential therapeutic interventions for blocking neuronal apoptosis after TBI.
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Metadata
Title
Bench-to-bedside review: Apoptosis/programmed cell death triggered by traumatic brain injury
Authors
Xiaopeng Zhang
Yaming Chen
Larry W Jenkins
Patrick M Kochanek
Robert SB Clark
Publication date
01-02-2004
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2005
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc2950

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