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Critical Care

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Open Access 01-04-2014 | Research

Immune derangement occurs in patients with H7N9 avian influenza

Authors: Wei Wu, Yu Shi, Hainv Gao, Weifeng Liang, Jifang Sheng, Lanjuan Li

Published in: Critical Care | Issue 2/2014

Abstract

Introduction

Currently, little is known about the immunological characteristics of patients with avian influenza A (H7N9) virus infection.

Methods

The numbers and percentages of peripheral blood immune cells were measured in 27 patients with laboratory-confirmed H7N9 virus infection and 30 healthy controls (HCs). The functional phenotypes of T cells and monocytes, as well as serum cytokine levels, were analyzed by flow cytometry.

Results

There were 19 patients (70.4%) with acute respiratory distress syndrome, 13 (48.1%) with secondary respiratory infection, 20 (74%) with systemic inflammatory response syndrome (SIRS; defined as having at least two concurrent SIRS components), 18 (66.7%) with lymphocytopenia and 11 (40.7%) with reduced numbers of monocytes. In comparison with levels in the HCs, the levels of serum interleukin 6 (IL-6), IL-8 and IL-10 and the percentages of CD38+ or Tim-3+ T cells were significantly increased. However, the percentages of human leukocyte antigen-DR + and Tim-3+ monocytes were significantly decreased in patients compared with HCs.

Conclusions

Patients with avian H7N9 virus infection display profound SIRS concomitantly with an anti-inflammatory response, which may be associated with the rapid progression of and high mortality associated with this novel viral disease.

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Title: Immune derangement occurs in patients with H7N9 avian influenza
Authors: Wei Wu
Yu Shi
Hainv Gao
Weifeng Liang
Jifang Sheng
Lanjuan Li
Publication date: 01-04-2014
Publisher: BioMed Central
Published in: Critical Care / Issue 2/2014
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc13788

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Immune derangement occurs in patients with H7N9 avian influenza

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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