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01-06-2013 | Review

Differentiated control of deranged nitric oxide metabolism: a therapeutic option in sepsis?

Authors: Corinna Lupp, Silke Baasner, Can Ince, Frank Nocken, John F Stover, Martin Westphal

Published in: Critical Care | Issue 3/2013

Abstract

Derangement of nitric oxide (NO) metabolism represents one of the key mechanisms contributing to macro- and microcirculatory failure in sepsis. Sepsis-related therapy combining fluid resuscitation with administration of vasopressor and inotropic agents, however, does not guarantee correction of maldistributed nutritive perfusion between and within organs. Therefore, the differentiated and selective pharmacologic modulation of NO-mediated vascular function could play a useful role in hemodynamic management of patients with sepsis. This viewpoint carefully evaluates the potential role of intentionally using partially opposing effects of NO donors and NO synthase inhibitors to complement current therapy of hemodynamic stabilization in patients with sepsis.

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Title: Differentiated control of deranged nitric oxide metabolism: a therapeutic option in sepsis?
Authors: Corinna Lupp
Silke Baasner
Can Ince
Frank Nocken
John F Stover
Martin Westphal
Publication date: 01-06-2013
Publisher: BioMed Central
Published in: Critical Care / Issue 3/2013
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc12538

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Differentiated control of deranged nitric oxide metabolism: a therapeutic option in sepsis?

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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