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Critical Care
Published in: Critical Care 5/2012

Open Access 01-10-2012 | Research

Relation between proteinuria and acute kidney injury in patients with severe burns

Authors: Jiong Yu Hu, Xin Chun Meng, Jian Han, Fei Xiang, Ya Dong Fang, Jun Wu, Yi Zhi Peng, Ya Zhou Wu, Yue Sheng Huang, Qi Zhi Luo

Published in: Critical Care | Issue 5/2012

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Abstract

Introduction

Proteinuria in burn patients is common, and may be associated with acute kidney injury (AKI) and adverse outcomes. We evaluated the incidences, outcomes, characteristics and determinants of proteinuria and its influence on AKI and outcomes in burn patients.

Methods

This retrospective study was carried out in a hospital's burn department. The study population consisted of patients with burn injuries admitted during a five-year period. Positive urine dipstick readings were defined as mild (± or 1+) or heavy (≥ 2+) proteinuria, and AKI was diagnosed and staged according to the Risk, Injury, Failure, Loss, End Stage (RIFLE) classification system. Patient characteristics, management and outcomes were evaluated for associations with proteinuria using nonparametric tests, chi-square (χ2) tests and binary logistic regression.

Results

Of the patients admitted to the burn unit during the study period (n = 2,497), 865 (34.64%) were classified as having proteinuria. In the patients whose total burn surface areas (TBSA) were > 30% (n = 396), 271 patients (68.43%) had proteinuria and 152 of these patients (56.09%) met AKI criteria. No patients without proteinuria developed AKI. Intensive care unit (ICU) mortality rates were 0.8%, 16.67% and 30.77% (P < 0.001) in the groups with no, mild and heavy proteinuria, respectively. Logistic regression analysis identified proteinuria (OR 4.48; 95% CI, 2.824 to 7.108; P < 0.001) and sequential organ failure assessment (OR 1.383; 95% CI, 1.267 to 1.509; P < 0.001) as risk factors for AKI.

Conclusions

We observed a high prevalence of proteinuria in patients with severe burns (> 30% TBSA). Severely burned patients with proteinuria had a high risk of developing AKI and a poor prognosis for survival. This suggests that proteinuria should be used for identifying burn patients at risk of developing AKI.
Appendix
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Metadata
Title
Relation between proteinuria and acute kidney injury in patients with severe burns
Authors
Jiong Yu Hu
Xin Chun Meng
Jian Han
Fei Xiang
Ya Dong Fang
Jun Wu
Yi Zhi Peng
Ya Zhou Wu
Yue Sheng Huang
Qi Zhi Luo
Publication date
01-10-2012
Publisher
BioMed Central
Published in
Critical Care / Issue 5/2012
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc11649

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