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Critical Care
Published in: Critical Care 5/2012

01-10-2012 | Letter

Concerns regarding use of one-tailed tests in the SLED-BD vs. CVVH trial

Author: Gordon S Doig

Published in: Critical Care | Issue 5/2012

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Excerpt

In the previous issue of Critical Care, I read with great interest the recent randomized controlled trial comparing sustained low-efficiency dialysis using a single-pass batch dialysis system (SLED-BD) with continuous veno-venous hemofiltration (CVVH) [1]. I congratulate the authors on their undertaking but have serious concerns regarding the majority of their analysis. After each table at the end of the paper, the authors report the use of a 'one-tailed Wilcoxon test' to assess continuous outcomes. I do not believe this use is appropriate. …
Literature
1.
Schwenger V, Weigand MA, Hoffmann O, Dikow R, Kihm LP, Seckinger J, Miftari N, Schaier M, Hofer S, Haar C, Nawroth PP, Zeier M, Martin E, Morath C: Sustained low efficiency dialysis using a single-pass batch system in acute kidney injury - a randomized interventional trial: the REnal Replacement Therapy Study in Intensive Care Unit PatiEnts. Crit Care. 2012, 16: R140-10.1186/cc11445.PubMedCentralCrossRefPubMed
2.
Kielstein JT, Kretschmer U, Ernst T, Hafer C, Bahr MJ, Haller H, Fliser D: Efficacy and cardiovascular tolerability of extended dialysis in critically ill patients: a randomized controlled study. Am J Kidney Dis. 2004, 43: 342-349. 10.1053/j.ajkd.2003.10.021.CrossRefPubMed
3.
Kumar VA, Craig M, Depner TA, Yeun JY: Extended daily dialysis: a new approach to renal replacement for acute renal failure in the intensive care unit. Am J Kidney Dis. 2000, 36: 294-300. 10.1053/ajkd.2000.8973.CrossRefPubMed
Metadata
Title
Concerns regarding use of one-tailed tests in the SLED-BD vs. CVVH trial
Author
Gordon S Doig
Publication date
01-10-2012
Publisher
BioMed Central
Published in
Critical Care / Issue 5/2012
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc11490

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