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Open Access 01-04-2012 | Research

Early neurovascular uncoupling in the brain during community acquired pneumonia

Authors: Bernhard Rosengarten, Dennis Krekel, Stefan Kuhnert, Richard Schulz

Published in: Critical Care | Issue 2/2012

Abstract

Introduction

Sepsis leads to microcirculatory dysfunction and therefore a disturbed neurovascular coupling in the brain. To investigate if the dysfunction is also present in less severe inflammatory diseases we studied the neurovascular coupling in patients suffering from community acquired pneumonia.

Methods

Patients were investigated in the acute phase of pneumonia and after recovery. The neurovascular coupling was investigated with a simultaneous electroencephalogram (EEG)-Doppler technique applying a visual stimulation paradigm. Resting EEG frequencies, visual evoked potentials as well as resting and stimulated hemodynamic responses were obtained. Disease severity was characterized by laboratory and cognitive parameters as well as related scoring systems. Data were compared to a control group.

Results

Whereas visually evoked potentials (VEP) remained stable a significant slowing and therefore uncoupling of the hemodynamic responses were found in the acute phase of pneumonia (Rate time: control group: 3.6 ± 2.5 vs. acute pneumonia: 1.6 ± 2.4 s; P < 0.0005). In the initial investigation, patients who deteriorated showed a decreased hemodynamic response as compared with those who recovered (gain: recovered: 15% ± 4% vs. deteriorated: 9% ± 3%, P < 0.05; control: 14% ± 5%). After recovery the coupling normalized.

Conclusions

Our study underlines the role of an early microcirculatory dysfunction in inflammatory syndromes that become evident in pre-septic conditions with a gradual decline according to disease severity.

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Title: Early neurovascular uncoupling in the brain during community acquired pneumonia
Authors: Bernhard Rosengarten
Dennis Krekel
Stefan Kuhnert
Richard Schulz
Publication date: 01-04-2012
Publisher: BioMed Central
Published in: Critical Care / Issue 2/2012
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc11310

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Early neurovascular uncoupling in the brain during community acquired pneumonia

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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