Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Critical Care
Published in: Critical Care 2/1997

Open Access 01-08-1997 | Research

A comparison of volume control and pressure-regulated volume control ventilation in acute respiratory failure

Authors: Henrik Guldager, Soeren L Nielsen, Peder Carl, Mogens B Soerensen

Published in: Critical Care | Issue 2/1997

Login to get access

Abstract

Background

The aim of this study was to test the hypothesis that a new mode of ventilation (pressure-regulated volume control; PRVC) is associated with improvements in respiratory mechanics and outcome when compared with conventional volume control (VC) ventilation in patients with acute respiratory failure. We conducted a randomised, prospective, open, cross over trial on 44 patients with acute respiratory failure in the general intensive care unit of a university hospital. After a stabilization period of 8 h, a cross over trial of 2 × 2 h was conducted. Apart from the PRVC/VC mode, ventilator settings were comparable. The following parameters were recorded for each patient: days on ventilator, failure in the assigned mode of ventilation (peak inspiratory pressure > 50 cmH2O) and survival.

Results

In the crossover trial, peak inspiratory pressure was significantly lower using PRVC than with VC (20 cmH2O vs 24 cmH2O, P < 0.0001). No other statistically significant differences were found.

Conclusions

Peak inspiratory pressure was significantly lower during PRVC ventilation than during VC ventilation, and thus PRVC may be superior to VC in certain patients. However, in this small group of patients, we could not demonstrate that PRVC improved outcome.
Literature
1.
Slustsky AS: ACCP consensus conference; mechanical ventilation. Chest 1993, 104: 1833-1859.CrossRef
2.
Webb HH, Tierney DF: Experimental pulmonary oedema due to intermittent positive pressure ventilation with high inflation pressures. Protection by positive end-expiratory pressure. Am Rev Respir Dis 1974, 199: 556-565.
3.
Corbridge TC, Wood LD, Crawford GP, Chudoba JR, Yanes J, Sznaider JL: Adverse effects of large tidal volume and low PEEP in canin acid aspiration. Am Rev Respir Dis 1990, 142: 311-315.CrossRefPubMed
4.
Mascheroni D, Kolobov T, Fumagalli R, et al.: Acute respiratory failure following pharmacologically-induced hyperventilation: an experimental animal study. Intensive Care Med 1987, 15: 8-14.
5.
Beale R, Grover ER, Smithies M, Bihari D: Acute respiratory distress syndrome (`ARDS'): no more than a severe acute lung injury? Br Med J 1993, 307: 1335-1339.CrossRef
6.
Gattinoni L, D'Andrea L, Pelosi P, Vitale G, Pesenti A, Fumagalli R: Regional effects and mechanism of positive end-expiratory pressure in early adult respiratory distress syndrome. JAMA 1993, 269: 2122-2127. 10.1001/jama.269.16.2122CrossRefPubMed
7.
Hickling KG, Walsh J, Henderson S, Jackson R: Low mortality rate in adult respiratory distress syndrome using low-volume, pressure-limited ventilation with permissive hypercapnia: a prospective study. Crit Care Med 1994, 22: 1568-1578.CrossRefPubMed
8.
Amato MBP, Barbas CSV, Mediros DM, et al.: Beneficial effects of `the open lung approach' with low distending pressures in ARDS. Am J Respir Crit Care Med 1995, 152: 1835-1846.CrossRefPubMed
9.
Rappaport SH, Shpiner R, Yoshihara G, Wright J, et al.: Randomized, prospective trial of pressure-limited versus volume-controlled ventilation in severe respiratory failure. Crit Care Med 1994, 22: 22-32.PubMed
10.
Böhm S, Lachmann B: Pressure-control ventilation. Putting a mode into perspective. J Intensive Care 1996, 3: 12-27.
Metadata
Title
A comparison of volume control and pressure-regulated volume control ventilation in acute respiratory failure
Authors
Henrik Guldager
Soeren L Nielsen
Peder Carl
Mogens B Soerensen
Publication date
01-08-1997
Publisher
BioMed Central
Published in
Critical Care / Issue 2/1997
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc107

Other articles of this Issue 2/1997

Critical Care 2/1997 Go to the issue

Commentary

Management of acidosis: the role of buffer agents

Research

Sex steroids in cardiopulmonary bypass

Research

Lack of agreement between bioimpedance and continuous thermodilution measurement of cardiac output in intensive care unit patients

Review

Equipment review: Gastric intramucosal pH measurement

Research

Minimizing charges associated with the determination of brain death

Research

Systematic review: The use of diuretics and dopamine in acute renal failure: a systematic review of the evidence