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Breast Cancer Research
Published in: Breast Cancer Research 1/2004

01-02-2004 | Commentary

New highlights on stroma–epithelial interactions in breast cancer

Authors: Mary Helen Barcellos-Hoff, Daniel Medina

Published in: Breast Cancer Research | Issue 1/2004

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Abstract

Although the stroma in which carcinomas arise has been previously regarded as a bystander to the clonal expansion and acquisition of malignant characteristics of tumor cells, it is now generally acknowledged that stromal changes are required for the establishment of cancer. In the present article, we discuss three recent publications that highlight the complex role the stroma has during the development of cancer and the potential for targeting the stroma by therapeutic approaches.
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Metadata
Title
New highlights on stroma–epithelial interactions in breast cancer
Authors
Mary Helen Barcellos-Hoff
Daniel Medina
Publication date
01-02-2004
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 1/2004
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr972

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