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Breast Cancer Research
Published in: Breast Cancer Research 6/2003

01-12-2003 | Review

The diagnosis and management of pre-invasive breast disease Genetic alterations in pre-invasive lesions

Authors: Jorge S Reis-Filho, Sunil R Lakhani

Published in: Breast Cancer Research | Issue 6/2003

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Abstract

The development of modern molecular genetic techniques has allowed breast cancer researchers to clarify the multistep model of breast carcinogenesis. Laser capture microdissection coupled with comparative genomic hybridisation and/or loss-of-heterozygosity methods have confirmed that many pre-invasive lesions of the breast harbour chromosomal abnormalities at loci known to be altered in invasive breast carcinomas. Current data do not provide strong evidence for ductal hyperplasia of usual type as a precursor lesion, although some are monoclonal proliferations; however, atypical hyperplasia and in situ carcinoma appear to be nonobligate precursors. We review current knowledge and the contribution of molecular genetics in the understanding of breast cancer precursors and pre-invasive lesions.
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Metadata
Title
The diagnosis and management of pre-invasive breast disease Genetic alterations in pre-invasive lesions
Authors
Jorge S Reis-Filho
Sunil R Lakhani
Publication date
01-12-2003
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 6/2003
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr650

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